Effect of ginsenoside Rg3 on the progression of orthotopically xenotransplanted human breast cancer in nude mice and its mechanism

Journal of Sichuan University (Medical Science)

Volumn 34, Issue 3, 2003, Pages 546-548

  Chen, Dafu ^a   Zhao, Yangbing ^b   Bai, Shaohuai ^b   Shi, Zongdao ^b   Zhang, Jie ^b  

^a No 421 Hospital of PLA   (China)

^b NONE

Author keywords

Angiogenesis; Ginsenoside Rg3; Human breast infiltrating duct carcinoma; Microvessel density; Vascular endothelial growth factor

Indexed keywords

CARBOXYMETHYLCELLULOSE; CYCLOPHOSPHAMIDE; GINSENOSIDE; GINSENOSIDE RG 3; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUDE MOUSE; ORTHOTOPIC TRANSPLANTATION; PROTEIN EXPRESSION; XENOGRAFT;

EID: 0141890009     PISSN: 1672173X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Folkman J. Clinical application of research on angiogenesis. New Engl J Med, 1995; 333(26): 1757
2. Thompson WD, William WL, Maragoudakis M, et al. The clinical manipulation of angiogenesis: pathology, side-effects, surprise and opportunities with novel human therapies. J Pathol, 2000; 190(3): 330
3. Gasparini G, Harris A. Clinical importance of the determination of tumor angiogenesis in breast carcinoma; much more than a new prognostic tool. J Clin Oncol, 1995; 139(3): 765
4. O'Reilly MS, Holmgren L, Shing Y, et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastasis by a Lewis lung carcinoma. Cell, 1994; 79(2): 315
5. Slaton JW, Perotte P, Inoue K, et al. Interferon alpha mediated down regulation of angiogenesis related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res, 1999; 5(10): 2726
6. Relf M, Lejeune S, Scott PA, et al. Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumour growth b1, platlet-derived endothelial cell growth factor, placental growth factor and pleiotrophin in human primary breast cancer and its relation to angiogenesis. Cancer Res, 1997; 57(5): 963
7. Weidner N. Intratumor microvessel density as a prognostic factor in cancer. Am J Pathol, 1995; 147(1): 9
8. Fan ZN, Isobe K, Kiuchi K, et al. Enhancement of nitric oxide production from activated macrophages by a purified form of ginsenoside (Rg1). Am J Chin Med, 1995; 23(3-4): 279
9. Imamura F, Horai T, Mukai M, et al. Serum requirement for in vitro invasion by tumor cells. Jpn J Cancer Res, 1991; 82 (5): 493