The Characterization of Molecular Organization of Multilamellar Emulsions Containing Pseudoceramide and Type III Synthetic Ceramide

Journal of Investigative Dermatology

Volumn 121, Issue 4, 2003, Pages 794-801

  Park, B D ^a   Youm, J K ^a   Jeong, S K ^b,c   Choi, E H ^d   Ahn, S K ^d   Lee, Seung Hun ^b,e  

^a NeoPharm Co Ltd   (South Korea)

^b Yonsei University   (South Korea)

^c AKI Central Research Laboratories   (South Korea)

^d Yonsei University Wonju College of Medicine   (South Korea)

^e Yonsei University College of Medicine   (South Korea)

Author keywords

Epidermal permeability barrier; Multilamellar emulsion; Pseudoceramide; Stratum corneum lipid; Synthetic ceramide

Indexed keywords

CERAMIDE DERIVATIVE; LIPID EMULSION; SKIN LIPID;

ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; HUMAN; LAMELLAR BODY; MOLECULAR DYNAMICS; PHASE TRANSITION; PRIORITY JOURNAL; SKIN FUNCTION; SKIN PERMEABILITY; STRATUM CORNEUM; STRUCTURAL HOMOLOGY; TEMPERATURE DEPENDENCE; TRANSMISSION ELECTRON MICROSCOPY; X RAY DIFFRACTION;

EID: 0141887511     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2003.12470.x     Document Type: Article

References (37)

1. Ahn SK, Hwang SM, Jiang SJ, Choi H, Lee SH: The changes of epidermal calcium gradient and transitional cells after prolonged occlusion following tape stripping in murine epidermis. J Invest Dermatol 113:189-195, 1999
2. Bleck O, Abeck D, Ring J: Two ceramide subfractions detectable in ceramide positions by HPTLC in skin surface lipids of non-lesional skin of atopic eczema. J Invest. Dermatol 113:894-900, 1999
3. Bouwstra JA, Gooris GS, van der Speck JA, Bras W: Structural investigations of human stratum corneum by small angle X-ray scattering. J Invest Dermatol 97:1005-1012, 1991
4. Bouwstra JA, Gooris GS, Salommons-de Vries MA, VanderSpeck JA, Bras W: Structure of human stratum corneum as a function of temperature and hydration: A wide angle X-ray diffraction study. Int J Pharm 84:205-216, 1992
5. Bouwstra JA, Gooris GS, van der Speck JA, Lavrijsen S, Bras W: The lipid and protein structure of mouse stratum corneum: A wide and small angle diffraction study. Biochim Biophys Acta 1212:183-192, 1994
6. Bouwstra JA, Gooris GS, Bras W, Downing DT: Lipid organization in pig stratum corneum. J Lipid Res 36:685-695, 1995
7. Bouwstra JA, Gooris GS, Cheng K, Weerheim A, Bras W, Ponec M: Phase behavior of isolated skin lipids. J Lipid Res 37:999-1011, 1996
8. Bouwstra JA, Gooris GS, Weerheim A, Ponec M: pH, cholesterol sulfate and fatty acids affect the stratum corneum lipid organization. J Invest Dermatol Symp Proc 3:69-74, 1998a
9. Bouwstra JA, Gooris GS, Dubbelaar FER, Weerheim A, Ljzerman AP, Ponec M: The role of ceramide 1 in the molecular organization of the stratum corneum lipids. J Lipid Res 39:186-196, 1998b
10. Bouwstra JA, Dubbelaar FER, Gooris GS, Weerheim AM, Ponec M: The role of ceramide composition in the lipid organization of the skin barrier. Biochim Biophys Acta 1419:127-136, 1999
11. Bouwstra JA, Gooris GS, Dubbelaar FER, Ponec M: Phase behavior of stratum corneum lipid mixtures based on human ceramides: The role of natural and synthetic ceramide 1. J Invest Dermatol 118:606-617, 2002
12. Choi EH, Ahn SK, Lee SH: The changes of stratum corneum interstices and calcium distribution of follicular epithelium of experimentally induced comedones (EIC) by oleic acid. Exp Dermatol 6:29-35, 1997
13. Elias PM, Bonar L, Grayson S, Baden HP: X-ray diffraction analysis of stratum corneum membrane couplets. J Invest Dermatol 80:213-214, 1983
14. Friberg SE, Kayali I, Rhein L, Hill R: A model for stratum corneum lipids and some implications. Cosmet Toiletries 102:135-140, 1987
15. Friberg SE, Al-Bawab A, Sandburg JD, Barber JL,Yin Q, Aikens PA: Phase behavior of a fragrance compound system: Water/phenethyl alcohol/laureth 4/glycerol. J Surfactants Detergents 2:159-165, 1999
16. Frobe C, Simion FA, Ohlmeyer H, Rhein LD, Matti J, Cagan RH, Friberg S: Prevention of stratum corneum lipid phase transition in-vitro by glycerol: An alternative mechanism for skin moisturization. J Soc Cosmet Chem 41:51-65, 1990
17. ten Grotenhuis E, Demel RA, Ponec M, Boer DR, van Miltenburg JC, Bouwstra JA: Phase behavior of stratum corneum lipids in mixed Langmiur-Blodgett monolayers. Biophys J 71:1389-1399, 1996
18. Kitson N, Thewalt J, Mafleur M, Bloom M: A model membrane approach to the epidermal permeability barrier. Biochemistry 33:6707-6715, 1994
19. Kuempel D, Swartzendruber DC, Squier CA, Wertz PW: In vitro reconstitution of stratum corneum lipid lamellae. Biochim Biophys Acta 1372:135-140, 1998
20. Lavrijsen SPM, Bouwstra JA, Gooris GS, Weerheim A, Bodde HE, Ponec M: Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis. J Invest Dermatol 305:619-624, 1995
21. Lee EJ, Shur KB, Lee JH, et al: The clinical efficacy of a multi-lamellar emulsion containing pseudoceramide in childhood atopic dermatitis: An open crossover study. Br J Dermatol (in submission)
22. Mao-Qiang M, Feingold KR, Thornfeldt CR, Elias PM: Optimization of physiological lipid mixtures for barrier repair. J Invest. Dermatol 106:1096-1101, 1996
23. Moore DJ, Rerck ME: Insight into the molecular organization of lipids on the skin barrier from infrared spectroscopy studies of stratum corneum lipid models. Acta Derm Venereol Suppl 208:16-22, 2000
24. Myers D: Surfactants in solution. Micellization and related association phenomena. In: Surfactant Science and Technology. New York: VCH Publishers Inc., 1988; p 136-141
25. Park BD, Lee M, Kim Y, Lee JG: The synthesis of new pseudoceramides using alkylketene dimer and their physical properties. J Ind Eng Chem 5:228-234, 1999
26. Park BD, Lee M, Kim Y, Youm JK: Synthesis of N-ethanol-2-(myristyl/palmityl)-3-oxo (stearamide/arachamide) and its physical properties for a cosmetic raw materials. J Comet Sci 51:253-262, 2000
27. Park BD, Kim Y, Lee M, Youm JK, Jeong SK, Choi EH, Lee SH: Formulation of a multi-lamellar emulsion using a pseudoceramide and its properties in vitro and in vivo system. Cosmet Toiletries 116:65-75, 2001a
28. Park BD, Youm JK, Lee SH: The clinical efficacy of multi-lamellar emulsion (MLE) contained pseudoceramide (PC-9S) on atopic dermatitis. JSBR 3:81-89, 2001b
29. Pilgram GSK, Elgelsma-van pelt AM, Oostergetel GT, Koerten HK, Bouwstra JA: Study on the lipid organization of stratum corneum lipid models by cryoelectron diffraction. J Lipid Res 39:1669-1676, 1998
30. Pilgram GSK, Englesma-Van Pelt AM, Bouwstra JA, Koerten HK: Electron diffraction provides new information on human stratum corneum lipid organization in relation to depth and temperature. J Invest Dermatol 113:403-409, 1999
31. Pilgram GSK, Vissers DCJ, van der Meulen H, Pavel S, Lavrijsen SPM, Bouwstra JA, Koerten HK: Aberrant lipid organization in stratum corneum patients with atopic dermatitis and lamellar ichthyosis. J Invest Dermatol 117:710-717, 2001
32. Rawlings A, Harding C, Watkinson A: The effect of glycerol and humidity on desmosome degradation in stratum corneum. Arch Dermatol Res 287:457-464, 1995
33. Rhein LD, Simion FA, Froebe C, Mattai J, Cagan RH: Development of a stratum corneum lipid model to study the cutaneous moisture barrier properties. Colloid Surfaces 48:1-11, 1990
34. Suzuki T: Secondary droplets formed in O/W emulsions. J Oil Chem Soc Jpn 35: 113-119, 1986
35. Swartzendruber DC, Wertz PW, Kitko DJ, Madison KC, Downing DT: Molecular modeling of the intercellular lipid lamellae in mammalian stratum corneum. J Invest Dermatol 92:251-257, 1989
36. White SH, Mirejovski D, King GI: Structure of lamellar lipid domains and corneocyte envelopes of murine stratum corneum: An X-ray diffraction study. Biochemistry 27:3725-3732, 1988
37. Yamamoto A, Serizawa S, Ito M, Sato Y: Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283:219-223, 1991