L- and DL-carnitine induce tetanic fade in rat neuromuscular preparation

Brazilian Journal of Medical and Biological Research

Volumn 36, Issue 9, 2003, Pages 1255-1262

  Lopes, G ^b   Bazotte, R B ^a   Curi, R ^b   Alves Do Prado, W ^a  

^a STATE UNIVERSITY OF MARINGÁ   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Atropine; Carnitine; Skeletal muscle; Tetanic fade

Indexed keywords

ATROPINE; CARNITINE; CHOLINE; HEMICHOLINIUM 3; TUBOCURARINE CHLORIDE;

ANIMAL TISSUE; ARTICLE; ATHLETE; BLOOD LEVEL; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DIAPHRAGM MUSCLE; ISOMERISM; MALE; METABOLITE; MUSCLE EXCITATION; MUSCLE TETANIC CONTRACTION; MUSCLE TONE; NERVE ENDING; NEUROMUSCULAR TRANSMISSION; NONHUMAN; PARALYSIS; PHRENIC NERVE; PHYSICAL PERFORMANCE; RAT; SKELETAL MUSCLE;

ANIMALIA;

EID: 0141886021     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/S0100-879X2003000900017     Document Type: Article

References (32)

1. Leibovitz B & Mueller J (1993). Carnitine. Journal of Optimal Nutrition, 2: 90-109.
2. Bieber LL (1988). Carnitine. Annual Review of Biochemistry, 57: 261-283.
3. Leibovitz B (1984). Carnitine - The Vitamin Bt Phenomenon. Dell Publishing Company, New York.
4. Rebouche C & Engel A (1980). Tissue distribution of carnitine biosynthetic enzymes in man. Biochimica et Biophysica Acta, 630: 22-29.
5. Rebouche CJ (1980). Comparative aspects of carnitine biosynthesis in microorganisms and mammals with attention to carnitine biosynthesis in man. In: Fraenkel RA & McGarry J (Editors), D-Carnitine Biosynthesis, Metabolism, and Functions. Academic Press, Inc., New York, 57-72.
6. Broquist HP & Borum PR (1982). Carnitine biosynthesis. Nutritional implications. Advances in Nutritional Research, 4: 181-204.
7. Borum P (1983). Carnitine. Annual Review of Nutrition, 3: 233-259.
8. Rebouche CJ (1986). Recent advances in carnitine biosynthesis and transport. In: Borum P (Editor), Clinical Aspects of Human Carnitine Deficiency. Pergamon Press, New York, 1-15.
9. Bremer J (1983). Carnitine - metabolism and functions. Physiological Reviews, 63: 1420-1480.
10. Bazilinski N & Dunea G (1990). Carnitine: an overview. International Journal of Artificial Organs, 13: 720-722.
11. Pahl MV, Varizi ND & Seo M (1990). Intestinal absorption of carnitine in experimental azotemia. Research Communications in Chemical Pathology and Pharmacology, 70: 337-347.
12. Kuwajima M, Kono N, Horiuchi M et al. (1991). Animal model of systemic carnitine deficiency: analysis in C3H-H-2 strain of mouse associated with juvenile visceral steatosis. Biochemical and Biophysical Research Communications, 174: 1090-1094.
13. Visentin M, Bellasio R & Tacconi MT (1995). Reye syndrome model in rats: protection against liver abnormalities by L-carnitine and acetyl-L-carnitine. Journal of Pharmacology and Experimental Therapeutics, 275: 1069-1075.
14. Dallemagne MJ, Philippot E, Binon F & Dumoulin EL (1955). Modes of action of carnitine and its derivatives on the motor-end-plates and ganglionic synapses of the rat. In: International Anesthesia Research Society, Proceedings of the World Congress of Anesthesiologists. Burgess Publishing Company, Minneapolis, MI, USA, 285-287.
15. Blum K, Seifter E & Seifter J (1971). The pharmacology of D- and L-carnitine and D- and L-acetylcarnitine: comparison with choline and acetylcholine. Journal of Pharmacology and Experimental Therapeutics, 178: 331-338.
16. Suzuki M, Kanaya M & Muramatsu S (1976). Effects of carnitine administration, fasting, and exercise on urinary carnitine excretion in man. Journal of Nutritional Science and Vitaminology, 22: 169-174.
17. Lennon D, Stratman F & Shrago E (1982). The effects of exercise training on carnitine status and physical work capacity in dialysis patients. Medicine and Science in Sports and Exercise, 14: 165 (Abstract).
18. Campos Y, Huertas R, Lorenzo G, Bautista J, Gutierrez E, Aparicio M, Alesso L & Arenas J (1993). Plasma carnitine insufficiency and effectiveness of L-carnitine therapy in patients with mitochondrial myopathy. Muscle and Nerve, 16: 150-153.
19. Campos Y, Huertas R, Bautista J et al. (1993). Muscle carnitine deficiency and lipid storage myopathy in patients with mitochondrial myopathy. Muscle and Nerve, 16: 778-781.
20. Arenas J, Gonzalez-Crespo MR, Campos Y, Martin MA, Cabello A & Gomez-Reino JJ (1996). Abnormal carnitine distribution in the muscles of patients with idiopathic inflammatory myopathy. Arthritis and Rheumatism, 39: 1869-1874.
21. Bowman WC (1980). Prejunctional and postjunctional cholinoceptors at the neuromuscular junction. Anesthesia and Analgesia, 59: 935-943.
22. Wessler I (1992). Acetylcholine at motor nerves: storage, release, and presynaptic modulation by autoreceptors and adrenoreceptors. International Review of Neurobiology, 34: 283-384.
23. Alves-do-Prado W, Corrado AP & Prado WA (1987). Reversal by atropine of tetanic fade induced in cats by antinicotinic and anticholinesterase agents. Anesthesia and Analgesia, 66: 492-496.
24. Rosemblueth A & Morison RS (1937). Curarization, fatigue and Wedensky inhibition. American Journal of Physiology, 119: 236-256.
25. Lennon D, Stratman F & Shrago E (1983). Effects of acute moderate-intensity exercise on carnitine metabolism in men and women. Journal of Applied Physiology, 55: 489-495.
26. Marconi C, Sassi G & Carpinelli A (1985). Effects of L-carnitine loading on the aerobic and anaerobic performance of endurance athletes. European Journal of Applied Physiology, 54: 131-135.
27. Gorostiaga E, Maurer C & Eclache J (1989). Decrease in respiratory quotient during exercise following L-carnitine supplementation. International Journal of Sports Medicine, 10: 169-174.
28. Angelini C, Vergani L & Costa G (1986). Clinical study of efficacy of L-carnitine and metabolic observations in exercise physiology. In: Borum P (Editor), Clinical Aspects of Human Carnitine Deficiency. Pergamon Press, New York, 38.
29. Bülbring E (1946). Observations on the isolated phrenic nerve diaphragm preparation of the rat. British Journal of Pharmacology, 1: 38-61.
30. Brown JH & Taylor P (1996). Muscarinic receptor agonists and antagonists. In: Hardman JG, Gilman AG & Limbird LE (Editors), The Pharmacological Basis of Therapeutics. 9th edn. McGraw-Hill, New York.
31. Tamai I, Ohashi R, Nezu J, Sai Y, Kobayashi D, Oku A, Shimane M & Tsuji A (2000). Molecular and functional characterization of organic cation/carnitine transporter family in mice. Journal of Biological Chemistry, 275: 40064-40072.
32. Rylett RJ & Colhoun EH (1984). An evolution of irreversible inhibition of synaptosomal high-affinity choline transport by choline mustard aziridinium ion. Journal of Neurochemistry, 43: 787-794.