메뉴 건너뛰기




Volumn 21, Issue 25-26, 2003, Pages 3961-3971

Fractionation, structural studies, and immunological characterization of the semi-synthetic Quillaja saponins derivative GPI-0100

Author keywords

Adjuvant; GPI 0100; Quillaja saponins; Saponin analogs

Indexed keywords

AMIDE; GAMMA INTERFERON; GLUCURONIC ACID; GPI 0100; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; N DICYCLOHEXYLUREA; SAPONIN DERIVATIVE; UFGPI 0100; UNCLASSIFIED DRUG; UREA DERIVATIVE;

EID: 0141882443     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(03)00298-6     Document Type: Article
Times cited : (59)

References (27)
  • 1
    • 0026033441 scopus 로고
    • Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex
    • Kensil C.R., Patel U., Marciani D. Separation and characterization of saponins with adjuvant activity from Quillaja saponaria Molina cortex. J. Immunol. 146:1991;431-437.
    • (1991) J. Immunol. , vol.146 , pp. 431-437
    • Kensil, C.R.1    Patel, U.2    Marciani, D.3
  • 2
    • 0037205174 scopus 로고    scopus 로고
    • Mechanism of stimulation of the immune response by aluminum adjuvants
    • HogenEsch H. Mechanism of stimulation of the immune response by aluminum adjuvants. Vaccine. 20:2002;S34-S39.
    • (2002) Vaccine , vol.20
    • HogenEsch, H.1
  • 3
    • 0028800377 scopus 로고
    • Structure/function studies of QS-21 adjuvant: Assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function
    • Soltysik S., Wu J.-Y., Recchia J., Wheeler D.A., Newman M.J.et al. Structure/function studies of QS-21 adjuvant: assessment of triterpene aldehyde and glucuronic acid roles in adjuvant function. Vaccine. 13:1995;1403-1410.
    • (1995) Vaccine , vol.13 , pp. 1403-1410
    • Soltysik, S.1    Wu, J.-Y.2    Recchia, J.3    Wheeler, D.A.4    Newman, M.J.5
  • 6
    • 0035106036 scopus 로고    scopus 로고
    • Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins
    • Marciani D.J., Pathak A.K., Reynolds R.C., Seitz L., May R.D. Altered immunomodulating and toxicological properties of degraded Quillaja saponaria Molina saponins. Int. Immunopharmacol. 1:2001;813-818.
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 813-818
    • Marciani, D.J.1    Pathak, A.K.2    Reynolds, R.C.3    Seitz, L.4    May, R.D.5
  • 7
    • 0001462811 scopus 로고
    • Structure of desacylsaponins obtained from the bark of Quillaja saponaria
    • Higuchi R., Tokimitsu Y., Fujioka T., Komori T., Kawasaki T.et al. Structure of desacylsaponins obtained from the bark of Quillaja saponaria. Phytochemistry. 26:1987;229-235.
    • (1987) Phytochemistry , vol.26 , pp. 229-235
    • Higuchi, R.1    Tokimitsu, Y.2    Fujioka, T.3    Komori, T.4    Kawasaki, T.5
  • 8
    • 85030953766 scopus 로고    scopus 로고
    • Kensil C, Soltysik S, Patel U, Marciani DJ. Structure-function relationship in adjuvants from Quillaja saponaria Molina. In: Brown F, Chanock RM, Ginsberg HS, Lerner RA, editors. Vaccine 92. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1992. p. 35-40.
    • Kensil C, Soltysik S, Patel U, Marciani DJ. Structure-function relationship in adjuvants from Quillaja saponaria Molina. In: Brown F, Chanock RM, Ginsberg HS, Lerner RA, editors. Vaccine 92. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 1992. p. 35-40.
  • 9
    • 0036844380 scopus 로고    scopus 로고
    • Degradation of Quillaja saponaria Molina saponins: Loss of the protective effects of a herpes simplex virus 1 sub-unit vaccine
    • Marciani D.J., Ptak R.G., Voss T.G., Reynolds R.C., Pathak A.K.et al. Degradation of Quillaja saponaria Molina saponins: loss of the protective effects of a herpes simplex virus 1 sub-unit vaccine. Int. Immunopharmacol. 2:2002;1703-1711.
    • (2002) Int. Immunopharmacol. , vol.2 , pp. 1703-1711
    • Marciani, D.J.1    Ptak, R.G.2    Voss, T.G.3    Reynolds, R.C.4    Pathak, A.K.5
  • 10
    • 0034662482 scopus 로고    scopus 로고
    • Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity
    • Marciani D.J., Press J.B., Reynolds R.C., Pathak A.K., Pathak V.et al. Development of semisynthetic triterpenoid saponin derivatives with immune stimulating activity. Vaccine. 18:2000;3141-3151.
    • (2000) Vaccine , vol.18 , pp. 3141-3151
    • Marciani, D.J.1    Press, J.B.2    Reynolds, R.C.3    Pathak, A.K.4    Pathak, V.5
  • 11
    • 0037150482 scopus 로고    scopus 로고
    • QS-21 structure/function studies: Effects of acylation on adjuvant activity
    • Liu G., Anderson C., Scaltreto H., Barbon J., Kensil C.R. QS-21 structure/function studies: effects of acylation on adjuvant activity. Vaccine. 20:2002;2808-2815.
    • (2002) Vaccine , vol.20 , pp. 2808-2815
    • Liu, G.1    Anderson, C.2    Scaltreto, H.3    Barbon, J.4    Kensil, C.R.5
  • 12
    • 0037055965 scopus 로고    scopus 로고
    • Quillaja saponin adjuvants: Derivatives formed under sub-optimal conditions
    • Marciani D.J., Pathak A.K., Reynolds R.D. Quillaja saponin adjuvants: derivatives formed under sub-optimal conditions. Vaccine. 20:2002;3237-3238.
    • (2002) Vaccine , vol.20 , pp. 3237-3238
    • Marciani, D.J.1    Pathak, A.K.2    Reynolds, R.D.3
  • 14
    • 0032823606 scopus 로고    scopus 로고
    • Separation and structural analysis of saponins in a bark extract from Quillaja saponaria Molina
    • Nord L.I., Kenne L. Separation and structural analysis of saponins in a bark extract from Quillaja saponaria Molina. Carbohydr. Res. 320:1999;70-81.
    • (1999) Carbohydr. Res. , vol.320 , pp. 70-81
    • Nord, L.I.1    Kenne, L.2
  • 15
    • 0031591086 scopus 로고    scopus 로고
    • Effect of a novel saponin adjuvant derived from Quillaja saponaria on the immune response to recombinant hepatitis B surface antigen
    • So H.S., Yoon H.S., Choi D.Y., Kwon Y.S., Sung J.H.et al. Effect of a novel saponin adjuvant derived from Quillaja saponaria on the immune response to recombinant hepatitis B surface antigen. Mol. Cells. 7:1997;178-186.
    • (1997) Mol. Cells , vol.7 , pp. 178-186
    • So, H.S.1    Yoon, H.S.2    Choi, D.Y.3    Kwon, Y.S.4    Sung, J.H.5
  • 17
    • 0030249914 scopus 로고    scopus 로고
    • Covalent chemical events in immune induction: Fundamental and therapeutic aspects
    • Rhodes J. Covalent chemical events in immune induction: fundamental and therapeutic aspects. Immunol. Today. 17:1996;436-441.
    • (1996) Immunol. Today , vol.17 , pp. 436-441
    • Rhodes, J.1
  • 18
    • 0029817013 scopus 로고    scopus 로고
    • Schiff base forming drugs. Mechanisms of immune potentiation and therapeutic potential
    • Chen H., Rhodes J. Schiff base forming drugs. Mechanisms of immune potentiation and therapeutic potential. J. Mol. Med. 74:1996;497-504.
    • (1996) J. Mol. Med. , vol.74 , pp. 497-504
    • Chen, H.1    Rhodes, J.2
  • 19
    • 0034727709 scopus 로고    scopus 로고
    • Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina
    • Guo S., Kenne L. Structural studies of triterpenoid saponins with new acyl components from Quillaja saponaria Molina. Phytochemistry. 55:2000;419-428.
    • (2000) Phytochemistry , vol.55 , pp. 419-428
    • Guo, S.1    Kenne, L.2
  • 20
    • 0029176755 scopus 로고    scopus 로고
    • Kensil CR, Wu J-Y, Soltysik S. Structural and immunological characterization of the vaccine adjuvant QS-21. In: Powell MF, Newman MJ, editors. Vaccine design: the subunit and adjuvant approach. New York: Plenum Press; 1995. p. 525-41.
    • Kensil CR, Wu J-Y, Soltysik S. Structural and immunological characterization of the vaccine adjuvant QS-21. In: Powell MF, Newman MJ, editors. Vaccine design: the subunit and adjuvant approach. New York: Plenum Press; 1995. p. 525-41.
  • 21
    • 0028171987 scopus 로고
    • Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma
    • Livingston P.O., Adluri S., Helling F., Yao T.J., Kensil C.R.et al. Phase 1 trial of immunological adjuvant QS-21 with a GM2 ganglioside-keyhole limpet haemocyanin conjugate vaccine in patients with malignant melanoma. Vaccine. 12:1994;1275-1280.
    • (1994) Vaccine , vol.12 , pp. 1275-1280
    • Livingston, P.O.1    Adluri, S.2    Helling, F.3    Yao, T.J.4    Kensil, C.R.5
  • 22
    • 85044700671 scopus 로고    scopus 로고
    • O'Hagan DT. Recent advances in vaccine adjuvants for systemic and mucosal administration. J Pharm Pharmacol 1998;49:1-10.
    • O'Hagan DT. Recent advances in vaccine adjuvants for systemic and mucosal administration. J Pharm Pharmacol 1998;49:1-10.
  • 23
    • 0033872729 scopus 로고    scopus 로고
    • The endogenous adjuvant squalene can induce a chronic T-cell mediated arthritis in rats
    • Carlson B.C., Jansson A.M., Larsson A., Butch A., Lorentzen J.C. The endogenous adjuvant squalene can induce a chronic T-cell mediated arthritis in rats. Am. J. Pathol. 156:2000;2057-2065.
    • (2000) Am. J. Pathol. , vol.156 , pp. 2057-2065
    • Carlson, B.C.1    Jansson, A.M.2    Larsson, A.3    Butch, A.4    Lorentzen, J.C.5
  • 24
    • 0036239706 scopus 로고    scopus 로고
    • The arthritogenic adjuvant squalene does not accumulate in joints, but gives rise to pathogenic cells in both draining and non-draining lymph nodes
    • Holm B.C., Svelander L., Butch A., Lorentzen J.C. The arthritogenic adjuvant squalene does not accumulate in joints, but gives rise to pathogenic cells in both draining and non-draining lymph nodes. Clin. Exp. Immunol. 127:2002;430-435.
    • (2002) Clin. Exp. Immunol. , vol.127 , pp. 430-435
    • Holm, B.C.1    Svelander, L.2    Butch, A.3    Lorentzen, J.C.4
  • 25
    • 0035888201 scopus 로고    scopus 로고
    • Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization
    • Glueck R. Pre-clinical and clinical investigation of the safety of a novel adjuvant for intranasal immunization. Vaccine. 20:2002;S42-S44.
    • (2002) Vaccine , vol.20
    • Glueck, R.1
  • 27
    • 0037108769 scopus 로고    scopus 로고
    • On the power of chemical synthesis: Immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines
    • Ragupathi G., Coltart D.M., Williams L.J., Koide F., Kagan E.et al. On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines. Proc. Natl. Acad. Sci. U.S.A. 99:2002;13699-13704.
    • (2002) Proc. Natl. Acad. Sci. U.S.A. , vol.99 , pp. 13699-13704
    • Ragupathi, G.1    Coltart, D.M.2    Williams, L.J.3    Koide, F.4    Kagan, E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.