The Effect of Hydrogen Peroxide Applied to the Middle Ear on Inner Ear Function

Laryngoscope

Volumn 113, Issue 11, 2003, Pages 2042-2046

  Perez, Ronen ^a   Freeman, Sharon ^b   Cohen, David ^a   Sichel, Jean Yves ^c   Sohmer, Haim ^b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^c HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

Author keywords

Auditory brainstem response; Hydrogen peroxide; Ototoxicity; Reactive oxygen species; Vestibular evoked potentials

Indexed keywords

GENTAMICIN; HYDROGEN PEROXIDE; POLYETHYLENE; REACTIVE OXYGEN METABOLITE; SODIUM CHLORIDE;

ANIMAL MODEL; ARTICLE; AUDITORY RESPONSE; BRAIN STEM RESPONSE; COCHLEA; CONTROLLED STUDY; EVOKED AUDITORY RESPONSE; HEARING; HUMAN; INNER EAR; LABYRINTHECTOMY; MIDDLE EAR; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSAMMOMYS OBESUS; RAT; VESTIBULAR FUNCTION;

ADMINISTRATION, TOPICAL; ANIMALS; ANTI-INFECTIVE AGENTS, LOCAL; AUDITORY THRESHOLD; COCHLEA; EAR, INNER; EAR, MIDDLE; EVOKED POTENTIALS, AUDITORY; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; GERBILLINAE; HYDROGEN PEROXIDE; OTOLOGIC SURGICAL PROCEDURES; PROSPECTIVE STUDIES; RATS; REACTIVE OXYGEN SPECIES; SODIUM CHLORIDE; VESTIBULE;

EID: 0141873200     PISSN: 0023852X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005537-200311000-00035     Document Type: Article

References (29)

1. Hirose K, Hockenbery DM, Rubel EW. Reactive oxygen species in chick hair cells after gentamicin exposure in vitro. Hear Res 1997;104:1-14.
2. Kopke RD, Liu W, Gabaizadeh R, et al. Use of organotypic cultures of Corti's organ to study the protective effect of antioxidant molecules on cisplatin-induced damage of auditory hair cells. Am J Otol 1997;18:559-571.
3. Quirk WS, Shivapuja BG, Schwimmer CL, Siedman MD. Lipid peroxidation inhibitor attenuates noise-induced temporary threshold shifts. Hear Res 1994;74:217-220.
4. de Groot H. Reactive oxygen species in tissue injury. Hepatogastroenterology 1994;41:328-332.
5. Brenman AK, Milner RM, Weller CR. Use of hydrogen peroxide to clear blocked ventilation tubes. Am J Otol 1986;7:47-50.
6. Spraggs PDR, Robinson PJ, Ryan R, East CA, Graham JM. A prospective randomized trial of the use of sodium bicarbonate and hydrogen peroxide ear drops to clear blocked tympanostomy tube. Int J Pediatr Otorhinolaryngol 1995;31:207-214.
7. Westin JG, Giannoni CM, Gajewski B, Antonelli PJ. Opening plugged tympanostomy tubes. Laryngoscope 2002;112:1342-1345.
8. Clerici WJ, DiMartino DL, Prasad MR. Direct effects of reactive oxygen species on cochlear outer hair cell shape in vitro. Hear Res 1995;84:30-40.
9. Clerici WJ, Yang L. Direct effects of intraperilymphatic reactive oxygen species generation on cochlear function. Hear Res 1996;101:14-22.
10. Dehne N, Lautermann J, ten Cate WJF, Rauen U, de Groot H. In vitro effects of hydrogen peroxide on the cochlear neurosensory epithelium of the guinea pig. Hear Res 2000;143:162-170.
11. Elidan J, Sohmer H, Nitzan M. Recording of short latency vestibular evoked responses to acceleration stimuli in rats by means of skin electrodes. Electroencephalogr Clin Neurophysiol 1982;53:501-505.
12. Elidan J, Sohmer H, Lev S, Gay I. Short latency vestibular evoked response to acceleration stimuli recorded by skin electrodes. Ann Otol Rhinol Laryngol 1984;93:257-261.
13. Plotnik M, Sichel J-Y, Elidan J, Honrubia V, Sohmer H. Origins of the short latency vestibular evoked potentials (VsEPs) to linear acceleration impulses. Am J Otol 1999;20:238-243.
14. Jones TA, Jones SM. Short latency compound action potentials from mammalian gravity receptor organs. Hear Res 1999;136:75-85.
15. Elidan J, Leibner E, Freeman S, Sela M, Nitzan M, Sohmer H. Short and middle latency vestibular evoked responses to acceleration in man. Electroencephalogr Clin Neurophysiol 1991;80:140-145.
16. Leibner E, Elidan J, Freeman S, Sela M, Nitzan M, Sohmer H. Vestibular evoked potentials with short and middle latencies recorded in humans. Electroencephalogr Clin Neurophysiol Suppl 1990;41:119-123.
17. Sohmer H. Auditory nerve and brainstem responses (ABR): physiological basis and clinical uses. In: Desmedt JE, ed. Neuromonitoring in Surgery. Amsterdam: Elsevier Science; 1989:23-47.
18. Elidan J, Langhofer L, Honrubia V. The neural generators of the vestibular evoked response. Brain Res 1987;423:385-390.
19. Freeman S, Plotnik M, Elidan J, Sohmer H. Differential effect of the loop diuretic furosemide on short latency auditory and vestibular-evoked potentials. Am J Otol 1999;20:41-45.
20. Sichel J-Y, Eliashar R, Plotnik M, Sohmer H, Elidan J. Assessment of vestibular ototoxicity of ear drops by recording of vestibular evoked potentials to acceleration impulses. Am J Otol 2000;21:192-195.
21. Perez R, Freeman S, Sohmer H, Sichel J-Y. Vestibular and cochlear ototoxicity of topical antiseptics assessed by evoked potentials. Laryngoscope 2000;110:1522-1527.
22. Sichel J-Y, Plotnik M, Cherny L, Sohmer H, Elidan J. Surgical anatomy of the ear of the fat sand rat. J Otolaryngol 1999;28:217-222.
23. Perez R, Ziv E, Freeman S, Sichel J-Y, Sohmer H. Vestibular end-organ impairment in an animal model of type 2 diabetes mellitus. Laryngoscope 2001;111:110-113.
24. Perez R, Freeman S, Cohen D, Sohmer H. Functional impairment of the vestibular end organ resulting from impulse noise exposure. Laryngoscope 2002;112:1110-1114.
25. Curthoys IS, Oman CM. Dimensions of the horizontal semi-circular duct, ampulla and utricle in rat and guinea pig. Acta Otolaryngol 1986;101:1-10.
26. Todt I, Ngezahayo A, Ernst A, Kolb HA. Hydrogen peroxide inhibits gap junctional coupling and modulates intracellular free calcium in cochlear Hensen cells. J Membrane Biol 2001;181:107-114.
27. Robinson AC, Hawke M. The efficacy of ceruminolytics: everything old is new again. J Otolaryngol 1989;18:263-267.
28. Hilton M, Chen J, Kakigi A, Hirakaya H, Mount RJ, Harrison RV. Middle ear instillation of gentamicin and streptomycin in chinchillas: electrophysiology appraisal of selective ototoxicity. Clin Otolaryngol 2002;27:529-535.
29. Roland PS. Clinical ototoxicity of topical antibiotic drops. Otolaryngol Head Neck Surg 1994;110:598-602.