α-hydroxybenzylphosphonate modified oligonucleotides: Synthesis, properties, and a novel route via monomer building blocks

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1123-1125

  Hohlfeld, Andreas ^a   Meier, Chris ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Antisense pro oligonucleotides; Building blocks; Hydroxybenzylphosphonate modification; Phosphinamidites

Indexed keywords

ALPHA HYDROXYBENZYLPHOSPHINAMIDITE; ANTISENSE OLIGONUCLEOTIDE; HYDROXYBENZYLPHOSPHONATE; MONOMER; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFERENCE PAPER; DNA HYBRIDIZATION; NUCLEOTIDE METABOLISM; RNA HYBRIDIZATION; SYNTHESIS;

INDICATORS AND REAGENTS; MOLECULAR CONFORMATION; OLIGONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHONIC ACIDS;

EID: 0141819325     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022816     Document Type: Conference Paper

References (2)

1. Mauritz, R.P.; Meier, C.; Uhlmann, E. Synthesis of 3′,5′ -dithymidylyl-α-hydroxyphosphonate dimer building blocks for oligonucleotide synthesis - a new pro-oligonucleotide approach. Nucleosides Nucleotides 1997, 16, 1209-1212.
2. Mauritz, R.P.; Meier, C. Fpmp-protected α-hydroxyphosphonate diesters for the synthesis of pro-oligonucleotides. Nucleosides Nucleotides 1997, 16, 675-678.