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Volumn 22, Issue 5-8, 2003, Pages 1421-1425
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Synthesis of high quality phosphorothioate oligonucleotides as antisense drugs. Use of I-linker in the elimination of 3′-terminal phosphorothioate monoesters
a
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Author keywords
3 terminal phosphorothioate monoester; Depurination; Detritylation; Oligomerization; Solid support
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Indexed keywords
5' O 4,4' DIMETHOXYTRITYL 2' DEOXYADENOSINE;
ANTISENSE OLIGONUCLEOTIDE;
DEOXYADENOSINE DERIVATIVE;
FOMIVIRSEN;
OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE;
OLIGONUCLEOTIDE;
PHOSPHOROTHIOIC ACID DERIVATIVE;
UNCLASSIFIED DRUG;
CHEMICAL REACTION;
CONFERENCE PAPER;
DEPROTECTION REACTION;
DEPURINATION;
DETRITYLATION;
DRUG ELIMINATION;
DRUG SYNTHESIS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
NUCLEOTIDE METABOLISM;
OLIGOMERIZATION;
QUALITY CONTROL;
REDUCTION;
SOLID;
SYNTHESIS;
BASE SEQUENCE;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
HYDROLYSIS;
INDICATORS AND REAGENTS;
MOLECULAR CONFORMATION;
MOLECULAR STRUCTURE;
OLIGODEOXYRIBONUCLEOTIDES;
OLIGONUCLEOTIDES;
OLIGONUCLEOTIDES, ANTISENSE;
PHOSPHATES;
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EID: 0141819231
PISSN: 15257770
EISSN: None
Source Type: Journal
DOI: 10.1081/NCN-120023000 Document Type: Conference Paper |
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Times cited : (7)
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References (0)
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