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Volumn 22, Issue 5-8, 2003, Pages 1415-1419
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Understanding high diastereomeric discrimination in formation of oligoribonucleotide phosphorothioate linkages: The first study of pKa-dependent activation in solid-supported coupling of 2′-O-substituted ribonucleoside phosphoramidites
a
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Author keywords
Activators; Coupling; Oligomerization; Phosphoramidite; Phosphorothioates; pKa; Solid support; Stereochemistry
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Indexed keywords
OLIGORIBONUCLEOTIDE;
PHOSPHORAMIDIC ACID DERIVATIVE;
PHOSPHOROTHIOIC ACID DERIVATIVE;
RIBONUCLEOSIDE PHOSPHORAMIDITE DERIVATIVE;
UNCLASSIFIED DRUG;
BINDING KINETICS;
CHEMICAL BINDING;
CHEMICAL COMPOSITION;
CONFERENCE PAPER;
DIASTEREOISOMER;
PKA;
SOLID;
SUBSTITUTION REACTION;
SYNTHESIS;
INDICATORS AND REAGENTS;
KINETICS;
MODELS, MOLECULAR;
MOLECULAR CONFORMATION;
OLIGORIBONUCLEOTIDES;
ORGANOPHOSPHORUS COMPOUNDS;
PHOSPHATES;
RIBONUCLEOTIDES;
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EID: 0141819230
PISSN: 15257770
EISSN: None
Source Type: Journal
DOI: 10.1081/NCN-120022999 Document Type: Conference Paper |
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Times cited : (6)
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References (0)
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