Potential role of endogenous and exogenous amyloid-beta binding molecules in the pathogenesis, diagnosis, and treatment of Alzheimer disease

Alzheimer Disease and Associated Disorders

Volumn 17, Issue 3, 2003, Pages 151-153

  Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E;

ALZHEIMER DISEASE; CLINICAL FEATURE; DRUG RESEARCH; HUMAN; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; REVIEW;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; APOLIPOPROTEINS E; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; SENILE PLAQUES;

EID: 0141818001     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002093-200307000-00006     Document Type: Review

References (8)

1. Strittmatter WJ, Weisgraker KH, Huang DY, et al. Binding of human apolipoprotein E to synthetic amyloid β peptide: isoform specific-effects and implications for late-onset Alzheimer disease. Proc Natl Acad Sci USA. 1993;90:8098-8102.
2. Holtzman DM, Bales KR, Tenkova T, et al. Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 2002a;97:2892-2897.
3. Holtzman DM, Fagan AM, Mackey B, et al. ApoE facilitates neuritic and vascular plaque formation in an Alzheimer's disease model. Ann Neurol. 2000b;47:739-747.
4. Fagan AM, Watson M, Parsadanian M, et al. Human and murine apoE markedly influence Aβ metabolism both prior and subsequent to plaque formation in a mouse model of Alzheimer's disease. Neurobiol Dis. 2002;9:305-318.
5. Bales KR, Verina T, Dodel RC, et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet. 1997;17:263-264.
6. DeMattos RB, O'Dell MA, Parsadanian M, et al. Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA. 2002b;99:10843-10848.
7. DeMattos RB, Bales KR, Cummins DJ, et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden. Proc Natl Acad Sci USA. 2001;98:8850-8855.
8. DeMattos RB, Bales KR, Cummins DJ, et al. Brain to plasma amyloid-β efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease. Science. 2002a;295:2264-2267.