Selection of a secretion-incompetent mutant in the serum of a patient with severe hepatitis B

Gastroenterology

Volumn 125, Issue 4, 2003, Pages 1077-1084

  Kalinina, Tatyana ^a,b   Riu, Anna ^a   Fischer, Lutz ^c   Santantonio, Theresa ^d   Will, Hans ^a   Sterneck, Martina ^a,c  

^a UNIVERSITY OF HAMBURG   (Germany)

^b D I IVANOVSKY INSTITUTE OF VIROLOGY   (Russian Federation)

^c UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^d Clinica Malattie Infettive   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; ENVELOPE PROTEIN; GLYCINE; GLYCINE CLEAVAGE SYSTEM; HEPATITIS B SURFACE ANTIBODY; HEPATITIS B SURFACE ANTIGEN; MEMBRANE PROTEIN; MUTANT PROTEIN; VIRUS DNA; VITRONECTIN;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD SAMPLING; CARBOXY TERMINAL SEQUENCE; CASE REPORT; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; GENE SEQUENCE; GENETIC TRANSFECTION; GENOME ANALYSIS; HEPATITIS B; HUMAN; LIVER TRANSPLANTATION; MALE; NONHUMAN; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN SECRETION; RECIPIENT; REINFECTION; VIRION; VIRUS ASSEMBLY; VIRUS DETECTION; VIRUS GENOME; VIRUS MUTANT; VIRUS REPLICATION; VIRUS STRAIN; WILD TYPE;

EID: 0141817732     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(03)01202-2     Document Type: Article

References (24)

1. Bartholomeusz A, Locarnini S. Hepatitis B virus mutants and fulminant hepatitis B: fitness plus phenotype. Hepatology 2001; 34:432-435.
2. Bruss V, Ganem D. The role of envelope proteins in hepatitis B virus assembly. Proc Natl Acad Sci U S A 1991;88:1059-1063.
3. Fortuin M, Karthigesu V, Allison L, Howard C, Hoare S, Mendy M, Whittle HC. Breakthrough infections and identification of a viral variant in Gambian children immunized with hepatitis B vaccine. J Infect Dis 1994;169:1374-1376.
4. Hsu HY, Chang MH, Ni YH, Lin HH, Wang SM, Chen DS. Surface gene mutants of hepatitis B virus in infants who develop acute or chronic infections despite immunoprophylaxis. Hepatology 1997; 26:786-791.
5. Hsu HY, Chang MH, Liaw SH, Ni YH, Chen HL. Changes of hepatitis B surface antigen variants in carrier children before and after universal vaccination in Taiwan. Hepatology 1999;30: 1312-1317.
6. Carman WF, Trautwein C, van Deursen FJ, Colman K, Dornan E, McIntyre G, Waters J, Kliem V, Muller R, Thomas HC, Manns MP. Hepatitis B virus envelope variation after transplantation with and without hepatitis B immune globulin prophylaxis. Hepatology 1996;24:489-493.
7. Ghany MG, Ayola B, Villamil FG, Gish RG, Rojter S, Vierling JM, Lok AS. Hepatitis B virus S mutants in liver transplant recipients who were reinfected despite hepatitis B immune globulin prophylaxis. Hepatology 1998;27:213-222.
8. Protzer-Knolle U, Naumann U, Bartenschlager R, Berg T, Hopf U, Meyer zum Buschenfelde KH, Neuhaus P, Gerken G. Hepatitis B virus with antigenically altered hepatitis B surface antigen is selected by high-dose hepatitis B immune globulin after liver transplantation. Hepatology 1998;27:254-263.
9. Ghendon Y. WHO strategy for the global elimination of new cases of hepatitis B. Vaccine 1990;8(suppl):S129-S133; discussion S134-S138.
10. Locarnini SA. Hepatitis B virus surface antigen and polymerase gene variants potential virological and clinical significance (editorial). Hepatology 1998;27:294-297.
11. Hawkins AE, Gilson RJ, Gilbert N, Wreghitt TG, Gray JJ, Ahlers-de Boer I, Tedder RS, Alexander GJ. Hepatitis B virus surface mutations associated with infection after liver transplantation. J Hepatol 1996;24:8-14.
12. Hasegawa K, Huang J, Rogers SA, Blum HE, Liang TJ. Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol 1994;68:1651-1659.
13. Sterneck M, Kalinina T, Gunther S, Fischer L, Santantonio T, Greten H, Will H. Functional analysis of HBV genomes from patients with fulminant hepatitis. Hepatology 1998;28:1390-1397.
14. Kajiya Y, Hamasaki K, Nakata K, Nakagawa Y, Miyazoe S, Takeda Y, Ohkubo K, Ichikawa T, Nakao K, Kato Y, Eguchi K. Full-length sequence and functional analysis of hepatitis B virus genome in a virus carrier: a case report suggesting the impact of pre-S and core promoter mutations on the progression of the disease. J Viral Hepat 2002;9:149-156.
15. Kalinina T, Riu A, Fischer L, Will H, Sterneck M. A dominant hepatitis B virus population defective in virus secretion because of several S-gene mutations from a patient with fulminant hepatitis. Hepatology 2001;34:385-394.
16. Sterneck M, Gunther S, Santantonio T, Fischer L, Broelsch CE, Greten H, Will H. Hepatitis B virus genomes of patients with fulminant hepatitis do not share a specific mutation. Hepatology 1996;24:300-306.
17. Lenhoff RJ, Summers J. Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus. J Virol 1994;68:4565-4571.
18. Melegari M, Scaglioni PP, Wands JR. The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted. J Virol 1997;71:5449-5454.
19. Xu Z, Yen TS. Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles. J Virol 1996;70:133-140.
20. Bock CT, Tillmann HL, Maschek HJ, Manns MP, Trautwein C. A preS mutation isolated from a patient with chronic hepatitis B infection leads to virus retention and misassembly. Gastroenterology 1997;113:1976-1982.
21. Loffler-Mary H, Dumortier J, Klentsch-Zimmer C, Prange R. Hepatitis B virus assembly is sensitive to changes in the cytosolic S loop of the envelope proteins. Virology 2000;270:358-367.
22. Chouteau P, Le Seyec J, Cannie I, Nassal M, Guguen-Guillouzo C, Gripon P. A short N-proximal region in the large envelope protein harbors a determinant that contributes to the species specificity of human hepatitis B virus. J Virol 2001;75:11565-11572.
23. Ueda K, Tsurimoto T, Matsubara K. Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles. J Virol 1991;65:3521-3529.
24. Clayton RF, Owsianka A, Patel AH. Evidence for structural differences in the S domain of L in comparison with S protein of hepatitis B virus. J Gen Virol 2001;82:1533-1541.