Dual effect of saikogenin D: In vitro inhibition of prostaglandin E 2 production and elevation of intracellular free Ca2+ concentration in C6 rat glioma cells

Planta Medica

Volumn 69, Issue 8, 2003, Pages 765-767

  Kodama, Yasuo ^a   Xiaochuan, Lv ^a   Tsuchiya, Chikako ^a   Ohizumi, Yasushi ^a   Yoshida, Makoto ^a   Nakahata, Norimichi ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CALCIMYCIN; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; SAIKOGENIN D; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INHIBITION; GLIOMA CELL; NONHUMAN; PROSTAGLANDIN SYNTHESIS INHIBITION; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BUPLEURUM; CALCIUM; CELL LINE, TUMOR; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLIOMA; OLEANOLIC ACID; PHYTOTHERAPY; PLANT ROOTS; PROSTAGLANDIN ANTAGONISTS; RATS;

ANIMALIA;

EID: 0141816793     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-42795     Document Type: Article

References (10)

1. Bermejo Benito P, Abad Martinez MJ, Silvan Sen AM, Sanz Gomez A, Fernandez Matellano L, Sanchez Contreras S et al. In vivo and in vitro anti-inflammatory activity of saikosaponins. Life Sci 1998; 63: 1147-56
2. Nishioka Y, Kyotani S, Miyamura M, Kusunose M. Influence of time of administration of a Shosaiko-to extract granule on blood concentration of its active constituents. Chem Pharm Bull (Tokyo) 1992; 40: 1335-7
3. Dayton ET, Majo EO. Recombinant human interleukin 1 induces production of prostaglandins in primary human fetal astrocytes and immortalized human fetal astrocyte cultures. J Neuroimmunol 1996; 71: 11-8
4. 2 in CSF from ALS patients. Neurology 2002; 58: 1277-9
5. 2) immunoreactivity is elevated in Alzheimer's disease brain. Neurobiol Dis 1996; 3: 51-63
6. Weaver JA, Maddox JF, Cao YZ, Mullarky IK, Sordillo LM. Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells. Free Rad Biol Med 2001; 30: 299-308
7. Matsushima T. Drug-induced pneumonitis and related diseases. Nippon Naika Gakkai Zasshi 1997; 86: 457-62
8. 2 synthesis by γ-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells. Biochem Pharmacol 2002; 63: 73-9
9. 2- production in HL-60 cells. Eur J Pharmacol 1996; 298: 87-95
10. 2+ concentrations in human astrocytoma cells. Br J Pharmacol 1994; 112: 299-303