Perillyl alcohol and perillaldehyde induced cell cycle arrest and cell death in BroTo and A549 cells cultured in vitro

Life Sciences

Volumn 73, Issue 22, 2003, Pages 2831-2840

  Elegbede, J Abiodun ^a   Flores, Richard ^a   Wang, Robert C ^b  

^a UNIVERSITY OF NEVADA   (United States)

^b UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cancer cells; Monoterpenes; Proliferation

Indexed keywords

DNA; LIPOCORTIN 5; PERILLALDEHYDE; PERILLYL ALCOHOL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE; CELL DEATH; CELL PROLIFERATION; CHRONOTHERAPY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIPLOIDY; DNA CONTENT; DNA DETERMINATION; DRUG EFFECT; DRUG INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LUNG ADENOCARCINOMA; SQUAMOUS CELL CARCINOMA;

EID: 0141791063     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(03)00701-X     Document Type: Article

References (24)

1. Andre H.A.M., Reutelingsperger C.P.M., Hauptmann R., Hemker H.C., Hermens W.T., Willems G.M. Binding of vascular anticoagulant α (VACα) to planar phospholipid bilayers. The Journal of Biological Chemistry. 265:1990;4923-4928.
2. Arends M.J., Morris R.G., Wyllie A.H. Apoptosis: The role of the endonuclease. American Journal of Pathology. 136:1990;593-608.
3. Ariazi E.A., Satomi Y., Ellis M.J., Haag J.D., Shi W., Sattler C.A., Gould M.N. Activation of the transforming growth factor β signaling pathway and induction of cytostasis and apoptosis in mammary carcinomas treated with the anticancer agent perillyl alcohol. Cancer Research. 59:1999;1917-1928.
4. Bedi A., Barber J.P., Bedi G.C., El-Deiry W.S., Sidransky D., Vala M.S., Akhtar A.J., Hilton J., Jones R.J. BCR-ABL-mediated inhibition of apoptosis with delay of G2/M transition after DNA damage: a mechanism of resistance to multiple anticancer agents. Blood. 86:1995;1148-1158.
5. Boersma A.W.M., Nooter K., Oostrum R.G., Stoter G. Quantification of apoptotic cells with fluorescein isothiocyanate-labeled annexin V in Chinese Hamster Ovary cell cultures treated with cisplatin. Cytometry. 24:1996;123-130.
6. Brown D., Wang R., Russell P. Antiepidermal growth factor receptor antibodies augment cytotoxicity of chemotherapeutic agents on squamous cell carcinoma cell lines. Otolaryngology Head Neck Surgery. 122:2000;75-83.
7. Clark S.S., Perman S.M., Sahin M.B., Jenkins G.J., Elegbede J.A. Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/ G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest. Leukemia. 16:2002;213-222.
8. Crowell P.L., Chang R.R., Ren Z., Elson C.E., Gould M.N. Selective inhibition of isoprenylation of 21-26 kDa protein by the anticarcinogen d-limonene and its metabolites. The Journal of Biological Chemistry. 266:1994;17679-17685.
9. Darzynkwiecz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M.A., Lassota P., Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry. 13:1992;795-808.
10. Darzynkiewicz Z., Li X., Gong J. Assays of cell viability: Discrimination of cells dying by apoptosis. Methods in Cell Biology. 41:1994;15-37.
11. Elegbede J.A., Elson C.E., Tanner M.A., Qureshi A., Gould M.N. Regression of rat mammary tumors following dietary d-limonene. Journal of the National Cancer Institute. 76:1986;323-325.
12. Fadok V.A., Voelker D.R., Campbell P.A., Cohen J.J., Bratton D.L., Henson P.M. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. Journal of Immunology. 148:1992;2207-2216.
13. Haag J.D., Gould M.N. Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene. Cancer Chemotherapy and Pharmacology. 34:1994;477-483.
14. Jirtle R.L., Haag J.D., Ariazi E.A., Gould M.N. Increased levels of M6P/IGF-II receptor and TGF-β1 levels during monoterpene-induced regression of mammary tumors. Cancer Research. 53:1993;3849-3852.
15. Karp F., Mihaliak C.A., Harris J.L., Croteau R. Monoterpene biosynthesis: Specificity of the hydroxylations of (-)-limonene by enzyme preparations from peppermint (Mentha piperita), spearmint, (Mentha spectat), and perilla (Perilla frutescens) leaves. Archives of Biochemistry and Biophysics. 276:1990;219-226.
16. Kelloff G.J., Crowell J.A., Hawk E.T., Steele V.E., Lubet R.A., Boone C.W., Covey J.M., Doody L.A., Omenn G.S., Greenwald P., Hong W.K., Parkinson D.R., Bagheri D., Baxter G.T., Blunden M., Doeltz M.K., Eisenhauer K.M., Johnson K., Longfellow D.G., Knapp G.G., Malone W.F., Nayfield S.G., Seifried H.E., Swall L.M., Sigman C.C. Clinical development plan: l-Perillyl alcohol. Journal of Cellular Biochemistry. 26S:1996;137-148.
17. McGarvey D.J., Croteau R. Terpenoid metabolism. Plant Cell. 7:1995;1015-1026.
18. Mills J.J., Chari R.S., Boyer I.J., Gould M.N., Jirtle R.L. Induction of apoptosis in liver tumors by the monoterpene perillyl alcohol. Cancer Research. 55:1995;979-983.
19. Mosmann T.J. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. Journal of Immunological Methods. 65:1983;55-63.
20. Ripple G.H., Gould M.N., Arzoomanian R.Z., Alberti D., Feierabend C., Simon K., Binger K., Tutsch K.D., Pomplun M., Wahamaki A., Marnocha R., Wilding G., Bailey H.H. Phase I clinical and pharmacokinetic study of perillyl alcohol administered four times a day. Clinical Cancer Research. 6:2000;390-396.
21. Sahin M.B., Perman S.M., Jenkins G., Clark S.S. Perillyl alcohol selectively induces G0/G1 arrest and apoptosis in Bcr/Abl-transformed myeloid cell lines. Leukemia. 13:1999;1581-1591.
22. Shi W., Gould M.N. Induction of cytostasis in mammary carcinoma cells treated with the anticancer agent perillyl alcohol. Carcinogenesis. 23:2002;131-142.
23. Vigushin D.M., Poon G.K., Boddy A., English J., Halbert G.W., Pagonis C., Jarman M., Coombes R.C. Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Chemotherapy Pharmacology. 42:1998;111-117.
24. Zhu J., Nabissa P.M., Hoffman B., Liebermann D.A., Shore S.K. Activated abl oncogenes and apoptosis: differing responses of transformed myeloid progenitor cell lines. Blood. 87:1996;4368-4375.