Synthesis of some N-galactosides of 3-aryl-5-benzyl (or substituted benzyl)-1,2,4-triazin-6(1H)-/ones or thiones of expected biological activity

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 9, 2003, Pages 1825-1833

  Mansour, Abdel Kader ^a   Eid, Mohga M ^a   Khalil, Nasser S A M ^b  

^a CAIRO UNIVERSITY   (Egypt)

^b Agricultural Research Center   (Egypt)

Author keywords

1,2,4 Triazines; N Galactosides; Synthesis

Indexed keywords

1,2,4 TRIAZINE DERIVATIVE; 2,3,4,6 TETRA O ACETYL ALPHA DEXTRO GALACTOPYRANOSYL BROMIDE; 5 BENZYL 1,2,4 TRIAZIN 6(1H) ONE DERIVATIVE; GALACTOSE; GALACTOSIDE; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; GALACTOSIDES; MOLECULAR STRUCTURE; TRIAZINES;

EID: 0141788616     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120023275     Document Type: Article

References (25)

1. Niedballa, U.; Vorbrüggen, H. Pyrimidine nucleosides. Ger. Offen. 1,919,307, Jan 14, 1971. Chem. Abstr. 1971, 74, 88267d.
2. Niedballa, U.; Vorbrüggen, H. Pyrimidine nucleosides. Ger. Offen. 1,919,307, Jan 14, 1971. Chem. Abstr. 1971, 74, 88267d.
3. Vorbrüggen, H.; Niedballa, U. Pyrimidine nucleosides. S. Afr. Pat, 70,02,144, Oct 26, 1970. Chem. Abstr. 1971, 75, 20912a.
4. Vorbrüggen, H.; Niedballa, U. Pyrimidine nucleosides. S. Afr. Pat, 70,02,144, Oct 26, 1970. Chem. Abstr. 1971, 75, 20912a.
5. Vorbrüggen, H.; Kolb, K.H.; Niedballa, U.; Strehlke, P. Therapeutical 2-thio-6-azauridines. Ger. Offen 1,955,695, May 13, 1971. Chem. Abstr. 1971, 75, 49513g.
6. Vorbrüggen, H.; Kolb, K.H.; Niedballa, U.; Strehlke, P. Therapeutical 2-thio-6-azauridines. Ger. Offen 1,955,695, May 13, 1971. Chem. Abstr. 1971, 75, 49513g.
7. Niedballa, U.; Vorbrüggen, H. Pyrimidine nucleosides. Ger, Offen. 1,943,428, Feb 25, 1971. Chem. Abstr. 1971, 74, 100361q.
8. Niedballa, U.; Vorbrüggen, H. Pyrimidine nucleosides. Ger, Offen. 1,943,428, Feb 25, 1971. Chem. Abstr. 1971, 74, 100361q.
9. Roy-Durman, P. Analogues of Nucleic Acid Components; Springer Verlag: Berlin-Heidelberg, New York, 1970; 42-45.
10. Beranek, J.; Sorm, F. Acyl derivatives of 6-azacytidine. Czech, Pat. 110,829, May 15, 1964. Chem. Abstr. 1964, 61, 13405f.
11. Beranek, J.; Sorm, F. Acyl derivatives of 6-azacytidine. Czech, Pat. 110,829, May 15, 1964. Chem. Abstr. 1964, 61, 13405f.
12. Zabolotnyi, D.K. Institute of Microbiology. 6-Azacytidine. Fr. Pat. 1, 386,727, Jan 22, 1965. Chem. Abstr. 1965, 62, 13222h.
13. Zabolotnyi, D.K. Institute of Microbiology. 6-Azacytidine. Fr. Pat. 1, 386,727, Jan 22, 1965. Chem. Abstr. 1965, 62, 13222h.
14. Restivo, A.R. Azauridines. U.S. Pat.3,412,083, Nov 19,1968. Chem. Abstr. 196970, 47807d.
15. Restivo, A.R. Azauridines. U.S. Pat.3,412,083, Nov 19,1968. Chem. Abstr. 196970, 47807d.
16. Mansour, A.K.; Eid, M.M.; Khahil, N.S. A. M. Selective synthesis and reactions of 6-substituted-2-β-galactosyl-1,2,4-triazines of potential anticancer activity. Nucleosides, Nucleotides & Nucleic Acids 2003, 22 (1), 21-44.
17. Mansour, A.K.; Ibrahim, Y.A.; Eid, M.M.; Abdel-Hady, S. A.L. N-glucosyl derivatives of some 1,2,4-triazines with tetra-O-acetyl-α-D-gucosyl bromide. J. Carbohydrates. Nucleosides. Nucleotides. 1981, 8 (2), 81-99.
18. Mansour, A.K.; Ibrahim, Y.A.; Eid, M.M. Nucleoside derivatives of 1,2,4-triazine. Reaction of some derivatives of 1,2,4-triazine with tetra-O-acetyl-α-D-glucopyranosyl bromide. Z. Naturforsch 1976, 31b, 505-508.
19. Eid, M.M.; Abdel Hady, S.A.; Ali, H.A.W. Reaction of some 1,2, 4-triazines with acetobromoglucose. Arch. Pharm. 1990, 243-245.
20. Ibrahim, Y.A. Facile approach for the selective glycosidation of cyclic asymmetric amides and thioamides. Carbohydrate Letters 1996, 1, 425-432.
21. Ibrahim, Y.A. Synthesis and structure of 2-deoxyribosyl-6-azauracil derivatives. Carbohydrate Letters 1996, 2, 189-195.
22. Mansour, A.K.; Ibrahim, Y.A.; Khalil, N.S. A. M. Selective synthesis and structure of 6-arylvinyl-2- and 4-glucosyl-1,2,4-triazines of expected interesting biological activity. Nucleosides & Nucleotides 1999, 18 (10), 2265-2283.
23. Nalepa, K., Bekarek, V.; Slouka, J. Reaction of azlactones with amino compounds. V. Synthesis and structure of 3,5-disubstituted 6-hydroxy-1,2,4-tri-azines. J. Prakt. Chem. 1972, 314 (5-6), 851-856.
24. Nalepa, K.; Slouka, J. Reactions of azlactones with amino compounds. I. hydrazinolysis of unsaturated azlactones and cyclization of the hydrazides formed to give 1,2,4-triazine derivatives. Monatsh. Chem. 1967, 98 (2), 412-416.
25. Furniss, B.S.; Hannaford, A.J.; Rogers, V.; Smith, P.W.G.; Tatchell, A.R. Vogel's Textbook of Practical Organic Chemistry, 4th Ed.; Longman group Limited, 1978; 458 pp.