Effects of helium-oxygen on respiratory mechanics, gas exchange, and ventilation-perfusion relationships in a porcine model of stable methacholine-induced bronchospasm

Intensive Care Medicine

Volumn 29, Issue 9, 2003, Pages 1560-1566

  Watremez, Christine ^b   Liistro, Giuseppe ^b   DeKock, Marc ^b   Roeseler, Jean ^b   Clerbaux, Thierry ^b   Detry, Bruno ^b   Reynaert, Marc ^b   Gianello, Pierre ^b   Jolliet, Philippe ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

Author keywords

Asthma; Helium; Methacholine; MIGET; Respiratory mechanics; Ventilation perfusion

Indexed keywords

CARBON DIOXIDE; HELIUM; METHACHOLINE; OXYGEN; WATER;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PH; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; BRONCHOSPASM; CLINICAL PROTOCOL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; GAS EXCHANGE; HYPERCAPNIA; LABORATORY; LUNG COMPLIANCE; LUNG PERFUSION; LUNG PRESSURE; LUNG RESISTANCE; LUNG VENTILATION PERFUSION RATIO; NONHUMAN; PARALYSIS; PROSPECTIVE STUDY; RANDOMIZATION; RESPIRATORY ACIDOSIS; STEADY STATE; SWINE; UNIVERSITY HOSPITAL;

ACUTE DISEASE; ANIMALS; ASTHMA; BRONCHIAL SPASM; BRONCHOCONSTRICTOR AGENTS; DISEASE MODELS, ANIMAL; HELIUM; METHACHOLINE CHLORIDE; OXYGEN INHALATION THERAPY; PULMONARY GAS EXCHANGE; RESPIRATION, ARTIFICIAL; RESPIRATORY MECHANICS; SWINE; TREATMENT OUTCOME; VENTILATION-PERFUSION RATIO;

EID: 0141788359     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-003-1779-y     Document Type: Article

References (41)

1. Afessa B, Morales I, Cury JD (2001) Clinical course and outcome of patients admitted to the ICU for status asthmaticus. Chest 120:1616-1621
2. Adnet F, Dhissi G, Borron SW, Galinski M, Rayeh F, Cupa M, Pourriat JL, Lapostolle F (2001) Complication profile of adult asthmatics requiring paralysis during mechanical ventilation. Intensive Care Med 27:1729-1736
3. Williams TJ, Tuxen DV, Scheinkestel GD, Czarny D, Bowes G (1992) Risk factors for morbidity in mechanically ventilated patients with acute severe asthma. Am Rev Respir Dis 146:607-615
4. Mansel JK, Stogner SW, Petrini MF, Norman JR (1990) Mechanical ventilation in patients with acute severe asthma. Am J Med 89:42-48
5. Rossi A, Polese G, Brandi G, Conti G (1995) Intrinsic positive end-expiratory pressure. Intensive Care Med 21:522-536
6. Tuxen D, Lane S (1987) The effects of ventilatory pattern on hyperinflation, airway pressures, and circulation in mechanical ventilation of patients with severe airflow obstruction. Am Rev Respir Dis 136:872-879
7. Papamoschou D (1995) Theoretical validation of the respiratory benefits of helium-oxygen mixtures. Respir Physiol 99:183-199
8. Manthous CA, Hall JB, Caputo MA, Walter J, Klocksieben JM, Schmidt GA, Wood LD (1995) Heliox improves pulsus paradoxus and peak expiratory flow in nonintubated patients with severe asthma. Am J Respir Crit Care Med 151:310-314
9. Kudukis TM, Manthous CA, Schmidt GA, Hall JB, Wylam ME (1997) Inhaled helium-oxygen revisited: effect of inhaled helium-oxygen during the treatment of status asthmaticus in children. J Pediatr 130:217-224
10. Kass JE, Castriotta RJ (1995) Heliox therapy in acute severe asthma. Chest 107:757-760
11. Gluck EH, Onorato DJ, Castriotta R (1990) Helium-oxygen mixtures in intubated patients with status asthmaticus and respiratory acidosis. Chest 98:693-698
12. Orsini AJ, Stefano JL, Leef KH, Jasani M, Ginn A, Tice L, Nadkarni VM (1999) Heliox improves pulmonary mechanics in a pediatric porcine model of induced severe bronchospasm and independent lung mechanical ventilation. Crit Care 3:65-70
13. Tassaux D, Jolliet P, Thouret JM, Roeseler J, Dome R, Chevrolet JC (1999) Calibration of seven ICU ventilators for mechanical ventilation with helium-oxygen mixtures. Am J Respir Crit Care Med 160:22-32
14. Manier G, Guénard H, Castaing Y, Varène N (1983) Respiratory gas exchange under heliox breathing in COPD studied by the inert gas method. Bull Eur Physiopathol Resp 19:401-406
15. 2 mixture in chronic obstructive lung disease. Bull Eur Physiopathol Resp 15:1053-1068
16. Watremez C, Roeseler J, De Kock M, Clerbaux T, Detry B, Reynaert M, Gianello P, Jolliet P, Liistro G (2003) An improved porcine model of stable methacholine-induced bronchospasm. Intensive Care Med 29:119-125
17. Fry DL, Stead WW, Ebert RV, Lubin RI, Wells HS (1952) The measurement of pleural pressure and its relationship to intrathoracic pressure. J Lab Clin Med 40:664-673
18. Baydur A, Behrakis PK, Zin WA, Milic-Emili G (1982) A simple method for assessing the validity of the esophageal balloon technique. Am Rev Respir Dis 732-739
19. Lauzon AM, Bates JH (1991) Estimation of time-varying respiratory mechanical parameters by recursive leastsquares. J Appl Physiol 71:1159-1165
20. Rossi A, Gottfried SB, Zocchi L, Higgs BD, Lennox S, Calverley A, Begin P, Grassino A, Milic-Emili J (1985) Measurement of static compliance of the total respiratory system in patients with acute respiratory failure during mechanical ventilation. The effect of intrinsic positive end-expiratory pressure. Am Rev Respir Dis 131:672-677
21. Sassoon CS, Mahutte CK (1998) Work of breathing during mechanical ventilation. In: Marini J, Slutsky A (ed) Physiological basis of ventilatory support. Dekker, New York, pp 261-310
22. Wagner PD, Saltzmann HA, West JB (1974) Measurement of continuous distributions of ventilation-perfusion ratios: theory. J Appl Physiol 36:588-599
23. Evans JW, Wagner PD (1977) Limits on VA/Q distributions from analysis of experimental inert gas elimination. J Appl Physiol 42:889-898
24. Breen PH, Becker LJ, Ruygrok P, Mayers I, Long GR, Left A, Wood LD (1987) Canine bronchoconstriction, gas trapping, and hypoxia with methacholine. J Appl Physiol 63:262-269
25. Echazaretta AL, Gomez FP, Ribas J, Sala E, Barbera JA, Roca J, Rodriguez-Roisin R (1991) Pulmonary gas exchange responses to histamine and methacholine challenges in mild asthma. Eur Respir J 17:609-614
26. Rodriguez-Roisin R, Ballester E, Roca J, Torres A, Wagner PD (1989) Mechanisms of hypoxemia in patients with severe status asthmaticus requiring mechanical ventilation. Am Rev Respir Dis 139:732-739
27. Rodriguez-Roisin R, Ferrer A, Navajas D, Agusti AG, Wagner PD, Roca J (1991) Ventilation-perfusion mismatch after methacholine challenge in patients with mild bronchial asthma. Am Rev Respir Dis 144:88-94
28. Rubinfeld AR, Wagner PD, West JB (1978) Gas exchange during acute experimental canine asthma. Am Rev Respir Dis 118:525-536
29. Martin JG, Shore SA, Engel LA (1983) Mechanical load and inspiratory muscle action during induced asthma. Am Rev Respir Dis 128:455-460
30. Wheatley JR, West S, Cala SJ, Engel GA (1990) The effect of hyperinflation on respiratory muscle work in acute i nduced asthma. Eur Respir J 3:625-632
31. O'Grady K, Doyle DJ, Irish J, Gullane P (1997) Biophysics of airflow within the airway: a review. J Otolaryngol 26:123-128
32. Otis AB, Bembower WC (1949) Effects of gas density on resistance to respiratory gas flow in man. J Appl Physiol 2:300-306
33. Grapé B, Channin E, Griffin P (1960) The effect of helium and oxygen mixtures on pulmonary resistances in emphysema. Am Rev Respir Dis 81:823-829
34. Connors AF, McCaffee DR, Gray BA (1981) Effect of inspiratory flow rate on gas exchange during mechanical ventilation. Am Rev Respir Dis 124:537-543
35. Tassaux D, Jollier P, Roeseler J, Chevrolet JC (2000) Effects of helium-oxygen on intrinsic positive end-expiratory pressure in intubated and mechanically ventilated patients with severe chronic obstructive pulmonary disease. Crit Care Med 28:2721-2728
36. Rodeberg DA, Easter AJ, Washam MA, Housinger TA, Greenhalgh DG, Warden GD (1995) Use of a helium-oxygen mixture in the treatment of postextubation stridor in pediatric patients with burns. J Burn Care Rehabil 16:476-490
37. Rodriguez-Roisin R (1997) Acute severe asthma: pathophysiology and pathobiology of gas exchange abnormalities. Eur Respir J 10:1359-1371
38. Schulz H, Schulz A, Eder G, Heyder J (1995) Influence of gas composition on convective and diffusive intrapulmonary gas transport. Exp Lung Res 21:853-876
39. 2 difference by helium breathing in the exercising horse. J Appl Physiol 76:2794-2801
40. Jolliet P, Tassaux D, Thouret JM, Chevrolet JC (1999) Beneficial effects of helium-oxygen vs. air-oxygen non-invasive pressure support in decompensated COPD patients. Crit Care Med 27:2422-2429
41. Schaeffer EM, Pohlman A, Morgan S, Hall JB (1999) Oxygenation in status asthmaticus improves during ventilation with helium-oxygen. Crit Care Med 27:2666-2670