An investigation of the biological effect of structural modifications of isothiosemicarbazones and their cyclic analogues

Farmaco

Volumn 58, Issue 9, 2003, Pages 951-959

  Maccioni, E ^a   Cardia, M C ^a   Distinto, S ^a   Bonsignore, L ^a   De Logu, A ^b  

^a UNIVERSITY OF CAGLIARI   (Italy)

^b 14 09123 Cagliari Italy   (Italy)

Author keywords

Anti fungal and anti microbial activity; Arylidenehydrazothiazoles; Arylideneisothiosemicarbazones

Indexed keywords

2 (2,4 DICHLOROBENZALCYCLOPENTYLIDEN) S (2 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (2,4 DICHLOROBENZALCYCLOPENTYLIDEN) S (2,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (2,4 DICHLOROBENZALCYCLOPENTYLIDEN) S (3,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (2,4 DICHLOROBENZALCYCLOPENTYLIDEN) S (3,4 DIMETHYLBENZYL)ISOTHIOSEMICARBAZONE; 2 (2,4 DICHLOROBENZALCYCLOPENTYLIDEN) S (4 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (3 NITROBENZALCYCLOPENTYLIDEN) S (2 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (3 NITROBENZALCYCLOPENTYLIDEN) S (2,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (3 NITROBENZALCYCLOPENTYLIDEN) S (3,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (3 NITROBENZALCYCLOPENTYLIDEN) S (3,4 DIMETHYLBENZYL)ISOTHIOSEMICARBAZONE; 2 (3 NITROBENZALCYCLOPENTYLIDEN) S (4 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 CHLOROBENZALCYCLOPENTYLIDEN) S (2 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 CHLOROBENZALCYCLOPENTYLIDEN) S (2,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 CHLOROBENZALCYCLOPENTYLIDEN) S (3,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 CHLOROBENZALCYCLOPENTYLIDEN) S (3,4 DIMETHYLBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 CHLOROBENZALCYCLOPENTYLIDEN) S (4 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 NITROBENZALCYCLOPENTYLIDEN) S (2 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 NITROBENZALCYCLOPENTYLIDEN) S (2,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 NITROBENZALCYCLOPENTYLIDEN) S (3,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 NITROBENZALCYCLOPENTYLIDEN) S (3,4 DIMETHYLBENZYL)ISOTHIOSEMICARBAZONE; 2 (4 NITROBENZALCYCLOPENTYLIDEN) S (4 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 BENZALCYCLOPENTYLIDEN S (2 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 BENZALCYCLOPENTYLIDEN S (2,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 BENZALCYCLOPENTYLIDEN S (3,4 DICHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 BENZALCYCLOPENTYLIDEN S (3,4 DIMETHYLBENZYL)ISOTHIOSEMICARBAZONE; 2 BENZALCYCLOPENTYLIDEN S (4 CHLOROBENZYL)ISOTHIOSEMICARBAZONE; 2 [2 (4 NITROBENZALCYCLOPENTYLIDEN)HYDRAZO] 4 PHENYLTHIAZOLE; 2 [2 (BENZALCYCLOPENTYLIDEN)HYDRAZO] 4 METHYLTHIAZOLE; THIAZOLE DERIVATIVE; THIOSEMICARBAZONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN;

EID: 0141788008     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(03)00154-X     Document Type: Article

References (10)

1. Cardia M.C., Begala M., DeLogu A., Maccioni E., Plumitallo A. Synthesis and antimicrobial activity of novel arylidenisothiosemicarbazones. Farmaco. 55:2000;93-98. references therein cited.
2. Maccioni E., Cardia M.C., Bonsignore L., Plumitallo A., Pellerano M.L., De Logu A. Synthesis and anti-microbial activity of isothiosemicarbazones and cyclic analogues. Farmaco. 57:2002;809-817.
3. Stork G., Brizzolara A., Landesman H., Szmuszkovicz J., Terrel R. The enamine alkylation and acylation of carbonyl compounds. J. Am. Chem. Soc. 85:1963;207-222.
4. Maccioni A., Marongiu E. Alcuni derivati del ciclopentanone - Nota II. Ann. Chim. 49:1959;1283-1287.
5. Birkofer L., Kim S.M., Engels H.D. Aldehydaddition an enamine. Chem. Ber. 95:1962;1495-1504.
6. Anchisi C., Baroli B.M., Fadda A.M., Maccioni A.M., Maccioni E., Sinico C. Synthesis of cis- and trans-2-arylmethylcycloalkylamines: potential dopaminergic agents. Farmaco. 52:1997;55-59.
7. Jagannath C., Reddy V.M., Gangadharam P.R. Enhancement of drug susceptibility of multi-drug resistant strains of Mycobacterium tuberculosis by ethambutol and dimethyl sulfoxide. J. Antimicrob. Chemother. 35:1995;381-390.
8. Trhupp L.D. Susceptibility testing of antibiotics in liquid media. Lorian V. Antibiotics in Laboratory Medicine. 1986;93-150 Williams and Wilkins, Baltimore, MD.
9. Washington J.A., Sutter V.L. Dilution susceptibility test: agar and macro-broth dilution procedures. Lennette E.H., Spaulding E.H., Truant J.I. Manual of Clinical Microbiology. 1980;533-544 American Society for Microbiology, Washington, DC.
10. Pfaller M.A., Rinaldi M.G., Galgiani J.N., Bartlett M.S., Body B.A., Espinel-Ingroff A., Fromtling R.A., Hall G.S., Hughes C.E., Odds F.C., Sugar A.M. Collaborative investigation of variables in susceptibility testing of yeasts. Antimicrob. Agents Chemother. 34:1990;1648-1654.