New supramolecular approach for saccharide-directed chemical modification of Concanavalin A

Chemistry Letters

Volumn 32, Issue 7, 2003, Pages 632-633

  Hayashida, Osamu ^a   Hamachi, Itaru ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; CARBOHYDRATE; CONCANAVALIN A; CYCLOPHANE; GLUCOSE;

AQUEOUS SOLUTION; ARTICLE; BINDING SITE; BIOSENSOR; CHEMICAL MODIFICATION; CHEMICAL REACTION; HYDROPHOBICITY; SUPRAMOLECULAR CHEMISTRY;

EID: 0141763743     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2003.632     Document Type: Article

References (12)

1. S. Gordon and S. Rabinowitz, Adv. Drug. Delivery Rev., 4, 27 (1989).
2. T. K. Dam and C. F. Brewer, Chem. Rev., 102, 387 (2002).
3. 2O: C, 51.64; H, 6.64; N, 5.13%.
4. O. Hayashida, K. Mizuki, K. Akagi, A. Matsuo, T. Kanamori, T. Nakai, S. Sando, and Y. Aoyama, J. Am. Chem. Soc., 125, 594 (2003).
5. O. Hayashida and I. Hamachi, Chem. Lett., 32, 288 (2003).
6. C. M. Yengo, L. R. Chrin, and C. L. Berger, J. Struct. Biol., 131, 187 (2000).
7. The host-guest complexation was estimated to be 85% for Dansyl-SE under such conditions.
8. a) I. Hamachi, T. Nagase, and S. Shinkai, J. Am. Chem. Soc., 122, 12065 (2000).
9. b) T. Nagase, S. Shinkai, and I. Hamachi, Chem. Commun., 2001, 229.
10. c) T. Nagase, E. Nakata, S. Shinkai, and I. Hamachi, Chem. - Eur. J., in press.
11. M. Onodera and K. Yagi, Biochem. Biophys. Acta, 253, 254 (1971).
12. Digestion of the dansyl-labeled Con A by trypsin coupled with MALDI-TOF MS experiments suggested that ε-amino group of K101 was modified with dansyl-SE.