Localization of T and B lymphocytes in histologically normal adult human donor liver

Hepato-Gastroenterology

Volumn 50, Issue 53, 2003, Pages 1311-1315

  Smith, Fiona ^a   Golden Mason, Lucy ^a   Deignan, Tina ^a   Norris, Suzanne ^c   Nolan, Niamh ^a   Traynor, Oscar ^a   McEntee, Gerry ^a   Hegarty, John ^a,b   O'Farrelly, Cliona ^a,b  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c Institute of Liver Studies   (United Kingdom)

Author keywords

B cell; Donor liver; Histology; Normal; T cell

Indexed keywords

ANTIBODY DETECTION; ARTICLE; B LYMPHOCYTE; CELL POPULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE MARKER; HUMAN; HUMAN TISSUE; LIVER GRAFT; ORGAN DONOR; PORTAL VEIN; PRIORITY JOURNAL; T LYMPHOCYTE; TISSUE SECTION; VITAL STAIN;

ADOLESCENT; ADULT; AGED; B-LYMPHOCYTES; CHILD; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LIVER; MALE; MIDDLE AGED; T-LYMPHOCYTES;

EID: 0141763576     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Hata K, Zhang XR, Iwatsuki S, Van Thiel DH, Herberman RB, Whiteside TL: Isolation, phenotyping, and functional analysis of lymphocytes from human liver. Clin Immunol Immunopathol 1990; 56:401-419.
2. Ishak K, Baptista A, Bianchi L, Callea F, De Groote J, Gudat F, Denk H, Desmet V, Korb G, MacSween RNM, Phillips J, Portmann BG, Poulsen H, Scheuer PJ, Schmid M, Thaler H: Histological grading and staging of chronic hepatitis. J Hepatol 1995; 22:696-699.
3. Schlitt H, Raddatz G, Steinhoff G, Wonigheit K, Pichlmayr R: Passenger lymphocytes in human liver allografts and their potential role after transplantation. Transplantation 1993; 56:951-955.
4. Pruvot FR, Navarro F, Janin A, Labalette M, Masy E, Lecomte-Houcke M, Gambiez L, Copin MC, Dessaint JP: Characterisation, quantification and localisation of passenger T lymphocytes and NK cells in human liver before transplantation. Transplant Int 1995; 8:273-279.
5. Cywes R, Mullen M, Stratis M, Greig P, Levy G, Harvey PR, Strasberg SM: Prediction of the outcome of transplantation in man by platelet adherence in donor liver allografts. Transplantation 1993; 56:316-323.
6. Kuichi T, Oldhafer KJ, Schlitt HJ, Nashan B, Deiwick A, Wonigeit K, Yamaoka Y, Pichlmayr R: Histochemical analysis of tissue injury in human hepatic grafts: potential usefulness in graft assessment before implantation. Transplant Proc 1996; 28:70-72.
7. Strasberg SM: Preservation injury and donor selection: It all starts here. Liver Transplant and Surg 1997; 3(Suppl 1):S1-S7.
8. Mor E, Klintmalm GB, Gonwa TA, Solomon H, Holman MJ, Gibbs JF, Watemberg I, Goldstein RM, Husberg BS: The use of marginal donors for liver transplantation. A retrospective study of 365 liver donors. Transplantation 1992; 53:383-386.
9. Ploeg RJ, D'Alessandro AM, Knechtle SJ, Stegall MD, Pirsch JD, Hoffmann RM, Sasaki T, Sollinger HW, Belzer FO, Kalayoglu M: Risk factors for primary dysfunction after liver transplantation-a multivariate analysis. Transplantation 1993; 55:807-813.
10. Garcia Urena MA, Colina Ruiz-Delgado F, Moreno Gonzalez E, Jimenez Romero C, Garcia Garcia I, Ioinzaz Segurola C, Gonzalez-Pinto, Gomez Sanz R: Hepatic steatosis in liver transplant donors: common feature of donor population? World J Surg 1998; 22:837-844.
11. Huang L, Sildevila G, Leeker M, Flavell RA, Crispe IN: Liver is the site of T cell destruction during peripheral deletion. Immunity 1994; 1:741-749.
12. Abe T, Weerasinghe A, Watanabe H: Extrathymic T cells in the liver. In: Crispe IN (Ed.). T lymphocytes in the liver New York: Wiley-Liss, 1999; pp. 59-90.
13. Norris S, Collins C, McEntee G, Traynor O, Hegarty J, O'Farrelly C: Resident human hepatic lymphocytes are phenotypically different from circulating lymphocytes. J Hepatol 1998; 28:84-90.
14. Mehal WZ, Azzaroli F, Crispe IN: Immunology of the healthy liver: Old questions and new insights. Gastroenterology 2001; 120:250-260.
15. Sato K, Ohtsuka K, Hasegawa K, Yamagiwa S, Watanabe H, Asakura H, Abo T: Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation. J Exp Med 1995; 182:759-767.
16. Taniguchi H, Toyoshima T, Fukao K, Nakauchi H: Presence of hematopoietic stem cells in the adult liver. Nature Med 1996; 2:198-203.
17. Makino Y, Yamagata N, Sasho T, Adachi Y, Kanno R, Koseki H, Kanno M, Taniguchi M: Extrathymic development of V alpha 14-positive T cells. J Exp Med 1993; 177:1399-1408.
18. Shimizu T, Sugahara S, Oya H, Muruyama S, Minagawa M, Bannai M, Hatakeyama K, Abo T: The majority of lymphocytes in the bone marrow, thymus and extrathymic T cells in the liver are generated in situ from their own preexisting precursors. Microbiol Immunol 1999; 43:595-608.
19. Crosbie OM, Reynolds M, McEntee G, Traynor O, Hegarty J, O'Farrelly C: In vitro evidence for the presence of hematopoietic stem cells in the adult human liver. Hepatology 1999; 29:1193-1198.
20. Golden-Mason L, Curry MP, Nolan N, Traynor O, McEntee G, Kelly J, Hegarty J, O'Farrelly C: Differential expression of lymphoid and myeloid markers on differentiating hematopoietic stem cells in normal and tumor-bearing adult human liver. Hepatology 2000; 31:1251-1256.
21. Golden-Mason L, Kelly AM, Traynor O, McEntee G, Kelly J, Hegarty JE, O'Farrelly C: Expression of Interleukin 7 (IL-7) mRNA and protein in the normal adult human liver: Implications for extrathymic T-cell development. Cytokine 2001; 14:143-151.
22. Collins C, Norris S, McEntee G, Traynor O, Bruno L, von Boehmer H, Hegarty J, O'Farrelly C: RAG1, RAG2 and pre-T cell receptor alpha chain expression by adult human hepatic T cells: evidence for extrathymic T cell maturation. Eur J Immunol 1996; 26:3114-3118.