A cyclopentane conformational restraint for a peptide nucleic acid: Design, asymmetric synthesis, and improved binding affinity to DNA and RNA

Organic Letters

Volumn 5, Issue 15, 2003, Pages 2695-2698

  Myers, Michael C ^a   Witschi, Mark A ^a   Larionova, Nataliya V ^a   Franck, John M ^a   Haynes, Russell D ^a   Hara, Toshiaki ^a,b   Grajkowski, Andrzej ^a,c   Appella, Daniel H ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPENTANE DERIVATIVE; PEPTIDE NUCLEIC ACID;

ARTICLE; ASYMMETRIC SYNTHESIS; BINDING AFFINITY; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; DNA BINDING; PROTEIN CONFORMATION; RING OPENING; RNA BINDING; STRUCTURE ANALYSIS;

ALKYLATION; CYCLOPENTANES; DNA; DRUG DESIGN; PEPTIDE NUCLEIC ACIDS; RNA; STEREOISOMERISM;

EID: 0141743429     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0348811     Document Type: Article

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