The relative contributions of cAMP and InsP3 pathways to olfactory responses in vertebrate olfactory receptor neurons and the specificity of odorants for both pathways

Journal of General Physiology

Volumn 122, Issue 3, 2003, Pages 247-250

  Barry, Peter H ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; CHLORIDE CHANNEL; CYCLIC AMP; INOSITOL 1,4,5 TRISPHOSPHATE;

ADAPTATION; CALCIUM TRANSPORT; DEPOLARIZATION; MEMBRANE CONDUCTANCE; NOTE; ODOR; OLFACTORY EPITHELIUM; OLFACTORY RECEPTOR; SECOND MESSENGER; SIGNAL TRANSDUCTION; SMELLING;

ANIMALS; CYCLIC AMP; INOSITOL 1,4,5-TRISPHOSPHATE; ODORS; OLFACTORY PATHWAYS; OLFACTORY RECEPTOR NEURONS; SMELL;

EID: 0141736797     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.200308910     Document Type: Note

References (28)

1. Balasubramanian, S., J.W. Lynch, and P.H. Barry. 1996. Calcium-dependent modulation of the agonist affinity of the mammalian cyclic nucleotide-gated channel by calmodulin and a novel endogenous factor. J. Membr. Biol. 152:13-23.
2. Belluscio, L., G.H. Gold, A. Nemes, and R. Axel. 1998. Mice deficient in G(olf) are anosmic. Neuron. 20:69-81.
3. Boekhoff, I., E. Tareilus, J. Strotmann, and H. Breer. 1990. Rapid activation of alternative second messenger pathways in olfactory cilia from rats by different odorants. EMBO J. 9:2453-2458.
4. Breer, H., and I. Boekhoff. 1991. Odorants of the same odor class activate different second messenger pathways. Chem. Senses. 16: 19-29.
5. Brunet, LJ., G.H. Gold, and J. Ngai. 1996. General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel. Neuron. 17:681-693.
6. Buck, L. 1996. Information coding in the vertebrate olfactory system. Annu. Rev. Neurosci. 19:517-544.
7. 3-odors". J. Neurophysiol. 84:575-580.
8. Fadool, D.A., and B.W. Ache. 1992. Plasma membrane inositol 1,4,5-trisphosphate-activated channels mediate signal transduction in lobster olfactory receptor neurons. Neuron. 9:907-918.
9. Gold, G.H. 1999. Controversial issues in vertebrate olfactory transduction. Annu. Rev. Physiol. 61:857-871.
10. Kashiwayanagi, M., K. Shimano, and K. Kurihara. 1996. Existence of multiple receptors in single neurons: responses of single bull-frog olfactory neurons to many cAMP-dependent and independent odorants. Brain Res. 738:222-228.
11. 3-gated channels and their occurrence relative to CNG channels in the sorna and dendritic knob of rat olfactory receptor neurons. J. Membr. Biol. 181:91-105.
12. Kleene, S.J., and R.C. Gesteland. 1991. Transmembrane currents in frog olfactory cilia. J. Membr. Biol. 120:75-81.
13. Kurahashi, T. 1989. Activation by odorants of cation-selective conductance in the olfactory receptor cell isolated from the newt. J. Physiol. 419:177-192.
14. Kurahashi, T., and A. Menini. 1997. Mechanism of odorant adaptation in the olfactory receptor cell. Nature. 385:725-729.
15. 2+-dependent adaptive properties in the solitary olfactory receptor cell of the newt. Brain Res. 515:261-268.
16. Kurahashi, T., and K.-W. Yau. 1993. Co-existence of cationic and chloride components in odorant-induced current of vertebrate olfactory receptor cells. Nature. 363:71-74.
17. Lischka, EW., M.M. Zviman, J.H. Teeter, and D. Restrepo. 1999. Characterization of inositol 1,4,5-trisphosphate-gated channels in the plasma membrane of rat olfactory neurons. Biophys. J. 76: 1410-1422.
18. Lowe, G., and G.H. Gold. 1993a. Contribution of the ciliary cyclic nucleotide-gated conductance to olfactory transduction in the salamander. J. Physiol. 462:175-196.
19. Lowe, G., and G.H. Gold. 1993b. Nonlinear amplification by calcium-dependent chloride channels in olfactory receptor cells. Nature. 366:283-286.
20. Nakamura, T., H.-H. Lee, H. Kobayashi, and T.-O. Satoh. 1996. Gated conductances in native and reconstituted membranes from frog olfactory cilia. Biophys. J. 70:813-817.
21. Restrepo, D., T. Miyamoto, B.P. Bryant, and J.H. Teeter. 1990. Odor stimuli trigger influx of calcium into olfactory neurons of the channel catfish. Science. 249:1166-1168.
22. Restrepo, D., J.H. Teeter, and D. Schild. 1996. Second messenger signaling in olfactory transduction. J. Neurobiol. 30:37-48.
23. Sklar, P.B., R.R. Anholt, and S.H. Snyder. 1986. The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants. J. Biol. Chem. 261:15538-15543.
24. Takeuchi, H., Y. Imanaka, J. Hirono, and T. Kurahashi. 2003. Cross-adaptation between olfactory responses induced by two-sub-groups of odorant molecules. J. Gen. Physiol. 122:255-264.
25. Sullivan, S.L., and L. Dryer. 1996. Information processing in mammalian olfactory system. J. Neurobiol. 30:20-36.
26. Wong, S.T., K. Trinh, B. Hacker, G.C. Chan, G. Lowe, A. Gaggar, Z. Xia, G.H. Gold, and D.R. Storm. 2000. Disruption of the type 1II adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 27:487-497.
27. Zufall, E, S. Firestein, and G.M. Shepherd. 1994. Cyclic nucleotide-gated ion channels and sensory transduction in olfactory receptor neurons. Annu. Rev. Biophys. Biomol. Struct. 23:577-607.
28. Zagotta, W.N., and S.A. Siegelbaum. 1996. Structure and function of cyclic nucleotide-gated channels. Annu. Rev. Neurosci. 19:235-263.