Case of acute lymphoblastic leukemia presenting with t(14;18)/BCL2, t(8;14)/cMYC, and t(1;2)/FCGR2B

American Journal of Hematology

Volumn 74, Issue 2, 2003, Pages 112-118

  Greer, Wenda L ^a,c   Lee, Christine L Y ^a   Callanan, Mary B ^b   Zayed, Ekram ^a   Sadek, Irene ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

^b INSTITUT ALBERT BONNIOT   (France)

^c QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

Author keywords

BCL2; Chromosomal translocations; CMYC; FCGR2B; Leukemia

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; AGED; ARTICLE; B LYMPHOCYTE; BLAST CELL; BURKITT LYMPHOMA; CANCER GRADING; CANCER INVASION; CASE REPORT; CELL MATURATION; CHROMOSOME 1Q; CHROMOSOME TRANSLOCATION; CHROMOSOME TRANSLOCATION 1; CHROMOSOME TRANSLOCATION 14; CHROMOSOME TRANSLOCATION 18; CHROMOSOME TRANSLOCATION 2; CHROMOSOME TRANSLOCATION 8; DISEASE COURSE; FCGR2B GENE; FOLLICULAR LYMPHOMA; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE LOCUS; GENE REARRANGEMENT; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; MALE; MOLECULAR GENETICS; ONCOGENE; ONCOGENE BCL 6; ONCOGENE C MYC; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTO ONCOGENE;

AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CYTOGENETIC ANALYSIS; FATAL OUTCOME; GENES, BCL-2; GENES, MYC; HUMANS; IMMUNOPHENOTYPING; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; MOLECULAR BIOLOGY; TRANSLOCATION, GENETIC;

EID: 0141730301     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/ajh.10393     Document Type: Article

References (24)

1. Levine EG, Arthur DC, Frizzera G, Patterson BA, Hurd DD, Bloomfield CF. Cytogenetic abnormalities predict outcome in non-Hodgkins lymphoma. Ann Int Med 1988;108:14-20.
2. Hockenbery D, Nunex G, Milliman C, Schreiber RD, Korsmeyer SJ. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990;348:334-336.
3. Gauwerky CE, Haluska FG, Tsujimoto Y, Nowell PC, Croce CM. Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene. Proc Natl Acad Sci USA 1988;85:8548-8552.
4. Bakhshi A, Wright JJ, Graninger W, Set M, Owens J, Cossman J, Jensen JR, Goldman P, Korsmeyer. Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci USA 1987;84:2396-2400.
5. Della-Favera R, Brengni M, Erickson J, Patterson D, Gallo RC, Croce CM. Human c-MYC onc gene is located on the region of chromosome 8 that is translocated in Burkitt's lymphoma cells. Proc Natl Acad Sci USA 1982;79:7824-2827.
6. Perry RP. Consequences of myc invasion of immunoglobulin loci: facts and speculation. Cell 1983;33:647-649.
7. Thangavelu M, Olopade O, Beckman E, Vardiman JW, Larson RA, McKeithan TW, LeBean MM, Rowley JD. Clinical, morphologic and cytogenetic characteristics of patients with lymphoid malignancies characterized by both t(14;18)(q32;q21) and t(8;14)(q24;q32) or t(8;22)(q24;q11). Genes Chromosomes Cancer 1990;2:147-158.
8. Karsan A, Gascoyne RD, Couplan RW, Shepherd JD, Phillips GL, Horseman DE. Combination of t(14;18) and a Burkitt's type translocation in B-cell malignancies. Leuk Lymphoma 1993;10:533-441.
9. Au WY, Gascoyne RD, Viswanatha DS, Skinnider BF, Connors JM, Klasa RJ, Horseman DE. Concurrent chromosomal alterations to 3q27, 8q 24 and 8q21 in B-cell lymphomas. Br J Haematol 1999;05:437-440.
10. Seabright M. A rapid banding technique for human chromosomes. Lancet 1971;971-972.
11. ISCN. An International System for Human Cytogenetic Nomenclature. Mitelman F, editor. Basel: S. Karger; 1995.
12. Stamatoullas A, Buchonnet G, Lepretre S, Lenain P, Lenormand B, Callat MP, Gaulard P, Bastard C, Tilly H. De novo acute B cell leukemia/lymphoma with t(14;18). Leukemia 2000;14:1960-1966.
13. Nacheva E, Dyer MJS, Fischer P, Stranks G, Heward JM, Marcus RE, Grace C, Karpas A. C-MYC translocations in de novo B-cell lineage acute leukemias with t(14;18) (cell lines Karpas 231 and 353). Blood 1993;82:231-240.
14. Cutrona G, Leanza N, Ulivi M, Melioli G, Burgio, VL, Mazzarello G, Gabutti G, Roncella S, Ferrarini M. Expression of CD10 by human T cells that undergo apoptosis both in vitro and in vivo. Blood 1999;94:3067-3076.
15. Cutrona G, Ulivi M, Fais F, Roncella S, Ferrarini M. Transfection of the c-MYC oncogene into normal Epstein-Barr virus-harboring B cells results in new phenotype and functional features resembling those of Burkitt's lymphoma cells and normal centroblasts. J Exp Med 1995;188:699-711.
16. Johansson B, Mertens F, Mitelman F. Cytogenetic evolution patterns in non-Hodgkin's lymphoma. Blood 1995;86:3905-3914.
17. Offit K, Wong G, Filippa DA, Tao Y, Chaganti RSK. Cytogenetic analysis of 434 consecutively ascertained specimens of non-Hodgkin's lymphoma: clinical correlations. Blood 1991;77: 1508-1515.
18. Callanan MB, Baccon PL, Mossuz P, Duley S, Bastard C, Hamoudi R, Dyer MJ, Klobeck G, Rimokh R, Sotto JJ, Leroux D. The IgG Fc receptor, FcγRIIB, is a target for deregulation by chromosomal translocation in malignancy lymphoma. Proc Natl Acad Sci USA 2000;97:309-314.
19. Ono M, Bolland S, Tempst P, Ravetch JV. Role of the inositol phosphatase SHIP in negative regulation of the immune system by the receptor Fcγ RIIB. Nature 1996;383:263-266.
20. Muta T, Kurosaki T, Misulovin Z, Sanchez M, Nussenzweig MC, Ravetch JV. A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling. Nature 1994;368: 70-73.
21. de Andres B, Mueller AL, Verbeek S, Sandor M, Lynch RG. A regulatory role for Fcγ receptors CD16 and CD32 in the development of murine B cells. Blood 1998;92:2823-2929.
22. Armitage JO, Sangor WG, Weisenburger DD, Harrigton DS, Linder J, Bierman PJ, Vose JM, Purtilo DT. Correlation of secondary cytogenetic abnormalities with histologic appearance in non-Hodgkin's lymphomas bearing t(14;18)(q32;q21). J Natl Cancer Inst 1988;80:576-580.
23. Richardson ME, Ouauguang C, Filippa DA, Offit K, Hampton A, Koduru PRK, Jhunwar SC, Lieberman PH, Clarkson BD, Chaganti RSK. Intermediate-to high-grade histology of lymphomas carrying t(14;18) is associated with additional non-random chromosome changes. Blood 1987;70:44-447.
24. Yunis JJ, Prizzer G, Oken MM, McKenna J, Theologides A, Arnesen. Multiple recurrent genomic defects in follicular lymphoma: a possible model for cancer. N Engl J Med 1987;316: 79-84.