Antimalarial activities of gedunin and 7-methoxygedunin and synergistic activity with dillapiol

Annals of Applied Biology

Volumn 143, Issue 2, 2003, Pages 135-141

  Omar, S ^a   Godard, K ^a   Ingham, A ^a   Hussain, H ^a   Wongpanich, V ^b   Pezzuto, J ^b,e   Durst, T ^a   Eklu, C ^c   Gbeassor, M ^c   Sanchez Vindas, P ^d   Poveda, L ^d   Philogene, B J R ^a   Arnason, J T ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF LOMÉ   (Togo)

^d UNIVERSIDAD NACIONAL   (Costa Rica)

^e PURDUE UNIVERSITY   (United States)

Author keywords

Dillapiol; Drug discovery; Gedunin; Malaria; Traditional medicine

Indexed keywords

DRUG DEVELOPMENT; MALARIA; MEDICINAL PLANT;

CEDRELA ODORATA; MELIACEAE; PLASMODIUM BERGHEI;

EID: 0141727492     PISSN: 00034746     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1744-7348.2003.tb00279.x     Document Type: Conference Paper

References (13)

1. Bernard C B. 1995. Biological activities and mode of action of lignans from the Piperaceae. Ph.D Thesis. University of Ottawa, Ottawa, Canada.
2. Bernard C B, Philogène B J R. 1993. Insecticide synergists: role, importance and perspectives. Journal of Toxicology and Environmental Health 38:199-223.
3. Bickii J, Hjifuite N, Foyere J A, Basco, I K, Ringwald, P. 2000. In vitro antimalarial activity of limonoids from Khaya grandifoliola. Journal of Ethnopharmacology 69:27-33.
4. Bray D H, Warhust D C, Connolly J D, O'Neill M J, Phillipson J D. 1990. Plants as sources of antimalarial drugs. Part 7. Activity of some species of Meliaceae plants and their constituent limonoids. Phytotherapeutic Research 4:29-35.
5. Budzinski J W, Foster B C, Vandenhoek S, Arnason J T. 2000. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial extracts and tinctures. Phytomedicine 7:1-10.
6. Desjardins R E, Canfield C J, Haynes C J, Chulay, J D. 1979. Assessment of antimalarial activity in vitro by semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy 16:710-718.
7. Hantos S. 1998. The Syntheses of Trichiliasterone A and B Isolated from Trichilia hirta and the Preparation of Derivatives of Antimalarial Agent Gedunin. M.Sc. Thesis, University of Ottawa, Ottawa, ON, Canada.
8. Khalid S A, Farouk A, Geary T G, Jensen J B. 1986. Potential antimalarial candidates from African plants: an in vitro approach using Plasmodium falciparum. Journal of Ethnopharmacology 15:201-209.
9. Leaman D J, Arnason J T, Yusuf R, Sangat-Roemantyo H. 1995. Malarial remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: a quantitative assessment of local consensus as an indicator of biological efficacy. Journal of Ethnopharmacology 49:1-16.
10. MacKinnon S, Durst T, Arnason J T, Angerhofer C. 1997. Antimalarial activity of tropical Meliaceae extracts and gedunin derivatives. Journal of Natural Products 60:336-341.
11. Obih P O, Makinde J M. 1985. Effect of Azadirachta indica on Plasmodium berghei in mice. African Journal of Medical Science 14:51-54.
12. Phillipson J D, Wright C W. 1991. Can ethnopharmacology contribute to the development of antimalarial agents. Journal of Ethnopharmacology 32:155-165.
13. Simonelli A P, Mehta S C, Higuchi W I. 1969. Dissolution rates of high energy PVP co-precipitates. Journal of Pharmaceutical Science 58:538-549.