Flavonoid treatment in patients with healed venous ulcer: Flow cytometry analysis suggests increased CD11b expression on neutrophil granulocytes in the circulation

Vascular Medicine

Volumn 8, Issue 2, 2003, Pages 83-88

  Danielsson, Gudmundur ^a   Norgren, Lars ^a   Truedsson, Lennart ^a   Andreasson, Annica ^a   Danielsson, Peter ^a   Nilsson, Anna ^a   Swartbol, Paul ^b  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Adhesion molecule; Chronic venous disease; Endothelial factors; White blood cell activation

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; CELL ADHESION MOLECULE; CYTOKINE; DIOSMIN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FLAVONOID; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; L SELECTIN;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CELL ACTIVATION; CELL SURFACE; CIRCULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; ENDOTHELIUM CELL; FEMALE; FLOW CYTOMETRY; GRANULOCYTE; HUMAN; INFLAMMATION; LEUKOCYTE; MALE; MICROCIRCULATION; MONOCYTE; NEUTROPHIL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; STANDING; ULCER; ULCER HEALING; UPREGULATION; VASCULAR DISEASE;

ADULT; AGED; ANTIGENS, CD18; DIOSMIN; E-SELECTIN; ENDOTHELIUM, VASCULAR; FEMALE; FLOW CYTOMETRY; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; INTERLEUKIN-8; L-SELECTIN; MALE; MICROCIRCULATION; MIDDLE AGED; NEUTROPHILS; STATISTICS, NONPARAMETRIC; VARICOSE ULCER;

EID: 0141719380     PISSN: 1358863X     EISSN: None     Source Type: Journal    
DOI: 10.1191/1358863x03vm471oa     Document Type: Article

References (11)

1. Moyses C, Cederholm-Williams SA, Michel CC. Haemoconcentration and accumulation of white cells in the feet during venous stasis. Int J Microcirc Clin Exp 1987; 5: 311-20.
2. Thomas PR, Dormandy JA. White cell and platelet trapping in patients with chronic venous insufficiency. Phlebologie 1988; 41: 771-76.
3. Veraart JC, Verhaegh ME, Neumann HA, Hulsmans RF, Arends JW. Adhesion molecule expression in venous leg ulcers. Vasa 1993; 22: 213-18.
4. Guilhou JJ, Dereure O, Marzin L et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: A double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997; 48: 77-85.
5. Jaschke E, Zabernigg A, Gattringer C. Recombinant human granulocyte-macrophage colony-stimulating factor applied locally in low doses enhances healing and prevents recurrence of chronic venous ulcers. Int J Dermatol 1999; 38: 380-86.
6. Shoab SS, Porter J, Scurr JH, Coleridge-Smith PD. Endothelial activation response to oral micronised flavonoid therapy in patients with chronic venous disease - A prospective study. Eur J Vasc Endovasc Surg 1999; 17: 313-18.
7. Saharay M, Shields DA, Porter JB, Scurr JH, Coleridge Smith PD. Leukocyte activity in the microcirculation of the leg in patients with chronic venous disease. J Vasc Surg 1997; 26: 265-73.
8. Saharay M, Shields DA, Georgiannos SN, Porter JB, Scurr JH, Coleridge Smith PD. Endothelial activation in patients with chronic venous disease. Eur J Vasc Endovasc Surg 1998; 15: 342-49.
9. Arnaout MA, Lanier LL, Faller DV. Relative contribution of the leukocyte molecules Mo1, LFA-1, and p150,95 (LeuM5) in adhesion of granulocytes and monocytes to vascular endothelium is tissue- and stimulus-specific. J Cell Physiol 1988; 137: 305-309.
10. Howlader M, Coleridge Smith PD. Endothelial activation in the microcirculation in patients with chronic venous disease. Int Angiol 2001; 20: 262.
11. Danielsson P, Schatz P, Swartbol P et al. Response of inflammatory markers to balloon angioplasty in peripheral arterial occlusive disease. Eur J Vasc Endovasc Surg 2000; 20: 550-55.