Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reaction

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 951-953

  Priego, E M ^a   Mendieta, J ^b   Gago, F ^b   Balzarini, J ^c   De Clercq, E ^c   Camarasa, M J ^a   Perez Perez M J ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF ALCALÁ   (Spain)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

2 Thiothymidine; Thymidine; Thymidine phosphorylase; Transition state

Indexed keywords

2 THIOTHYMIDINE; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; HISTIDINE; LYSINE; PHOSPHATE; PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR; PYRIMIDINE; THYMIDINE DERIVATIVE; THYMIDINE PHOSPHORYLASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CATALYSIS; CONFERENCE PAPER; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME MECHANISM; MOLECULAR DYNAMICS;

BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HISTIDINE; KINETICS; PROTEIN CONFORMATION; THYMIDINE PHOSPHORYLASE; THYMINE;

EID: 0141708703     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022693     Document Type: Conference Paper

References (2)

1. Esteban-Gamboa, A.; Balzarini, J.; Esnouf, R.; De Clercq, E.; Camarasa, M.J.; Pérez-Pérez, M.J. Design, synthesis and enzymatic evaluation of multisubstrate analogue inhibitors of Escherichia coli thymidine phosphorylase. J. Med. Chem. 2000, 43, 971-983.
2. Pugmire, M.J.; Ealick, S.E. The crystal structure of pyrimidine nucleoside phosphorylase in a closed conformation. Structure 1998, 6, 1467-1479.