New lipophilic derivatives of AZT and d4T 5′-phosphonates

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 981-985

  Shirokova, Elena A ^a   Jasko, Maxim V ^a   Khandazhinskaya, Anastasiya L ^a   Yanvarev, Dmitry V ^a   Skoblov, Yury S ^a   Pronayeva, Tatyana R ^b   Fedyuk, Nina V ^b   Pokrovsky, Andrey G ^b   Kukhanova, Marina K ^a  

^a ENGELHARDT INSTITUTE OF MOLECULAR BIOLOGY   (Russian Federation)

^b STATE RESEARCH CENTER OF VIROLOGY AND BIOTECHNOLOGY VECTOR   (Russian Federation)

Author keywords

Anti HIV agents; AZT and d4T derivatives; Nucleoside 5 phosphonates

Indexed keywords

5' AMINOCARBONYLPHOSPHONYL DIESTER; AMINOCARBONYLMETHYLPHOSPHONYL DIESTER; ANTIVIRUS AGENT; FOSCARNET; PHOSPHONIC ACID DERIVATIVE; PHOSPHONOACETIC ACID; STAVUDINE; UNCLASSIFIED DRUG; ZIDOVUDINE DERIVATIVE;

ANTIVIRAL ACTIVITY; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONFERENCE PAPER; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPOPHILICITY; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-HIV AGENTS; CELL DIVISION; CELL LINE; CELLS, CULTURED; DRUG STABILITY; HALF-LIFE; HIV-1; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; PHOSPHONIC ACIDS; STAVUDINE; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0141708693     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022718     Document Type: Conference Paper

References (3)

1. Rozowsky, A.; Saha, J.; Fazely, F.; Koch, J.; Ruprecht, R.M. Inhibition of human immunodeficiency virus type 1 replication by phosphonoformate esters of 3′-azido-3′-deoxythymidine. Biochem. Biophys. Res. Commun. 1990, 172, 288-294.
2. Rozowsky, A.; Fu, H.; Pai, N.; Mellors, J.; Richman, D.D.; Hostetler, K.Y. Synthesis and in vitro activity of long-chain 5′ -O-((alkoxycarbonyl)phosphinyl)-3′-azido-3′-deoxythymidines against wild-type and AZT- and Foscarnet-resistant strains of HIV-1. J. Med. Chem. 1997, 40, 2482-2490.
3. Meier, C.; Aubertin, A.M.; de Monte, M.; Faraj, A.; Sommadossi, J.P.; Perigaud, C.; Imbach, J.L.; Gosselin, G. Synthesis and antiviral evaluation of SATE-foscarnet prodrugs and new foscarnet-AZT conjugates. Antiviral Chem. & Chemotherapy 1998, 1, 41-52.