Alterations in conjunctival cytology and tear film dysfunction in patients with β-thalassemia

Cornea

Volumn 22, Issue 7, 2003, Pages 591-597

  Gartaganis, Sotirios P ^a   Georgakopoulos, C D ^a   Exarchou, A ^a   Mela, E K ^a   Psachoulia, C ^a   Eliopoulou, M I ^a   Kourakli, A ^a   Gotsis, S S ^b   Tripathi, R C ^c  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^c UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

thalassemia; Brush cytology; Iron overload; Squamous metaplasia; Tear film

Indexed keywords

ROSE BENGAL;

ADOLESCENT; ADULT; AGE; ARTICLE; BETA THALASSEMIA; CONJUNCTIVA; CONJUNCTIVA EPITHELIUM; CONTROLLED STUDY; CYTOLOGY; DISEASE ASSOCIATION; FEMALE; GOBLET CELL; HUMAN; INFLAMMATORY CELL; MAJOR CLINICAL STUDY; MALE; PAPANICOLAOU TEST; PRIORITY JOURNAL; SCHIRMER TEST; SQUAMOUS CELL METAPLASIA; TEAR FILM;

ADOLESCENT; ADULT; BETA-THALASSEMIA; CELL COUNT; CONJUNCTIVA; FEMALE; FLUORESCENT DYES; GOBLET CELLS; HUMANS; MALE; ROSE BENGAL; STAINING AND LABELING; TEARS;

EID: 0141708667     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003226-200310000-00002     Document Type: Article

References (38)

1. Zurlo MG, De Stefano P, Borgna-Pignatti C, et al. Survival and causes of death in thalassaemia major. Lancet. 1989;2:27-30.
2. Modell B. Advances in the use of iron-chelating agents for the treatment of iron overload. Prog Hematol. 1979;11:267-312.
3. Bloomfield SE, Markenson AL, Miller DR, et al. Lens opacities in thalassemia. J Pediatr Ophthalmol Strabismus. 1978;15:154-156.
4. Davies SC, Marcus RE, Hungerford JL, et al. Ocular toxicity of high-dose intravenous desferrioxamine. Lancet. 1983;2:181-184.
5. Gartaganis SP, Zoumbos N, Koliopoulos JX, et al. Contrast sensitivity function in patients with beta-thalassemia major. Acta Ophthalmol Scand. 2000;78:512-515.
6. Gullo L, Corcioni E, Brancati C, et al. Morphologic and functional evaluation of the exocrine pancreas in beta-thalassemia major. Pancreas. 1993;8:176-180.
7. Montalto G, D'Angelo P, Lo Casto A, et al. Serum and fecal pancreatic enzymes in beta-thalassemia major. Int J Pancreatol. 1997;22:131-135.
8. De Sanctis V, Vullo C, Bagni B, et al. Hypoparathyroidism in beta-thalassemia major. Clinical and laboratory observations in 24 patients. Acta Haematol. 1992;88:105-108.
9. Carpino A, De Sanctis V, Siciliano L, et al. Epididymal and sex accessory gland secretions in transfusion-dependent beta-thalassemic patients: evidence of an impaired prostatic function. Exp Clin Endocrinol Diabetes. 1997;105:169-174.
10. Goldfarb A, Nitzan DW, Marmary Y. Changes in the parotid salivary gland of beta-thalassemia patients due to hemosiderin deposits. Int J Oral Surg. 1983;12:115-119.
11. Vrielinck LJ, van Parys G, van Damme B, et al. Sicca syndrome with iron deposition in the salivary glands. Int J Oral Maxillofac Surg. 1988;17:11-13.
12. Takeda Y, Yamamoto H. Iron deposits in the human labial minor salivary glands: a postmortem study. J Nihon Univ Sch Dent. 1989;31:361-365.
13. Borgna-Pignatti C, Cammareri V, De Stefano P, et al. The sicca syndrome in thalassaemia major. Br Med J (Clin Res Ed). 1984;288:668-669.
14. Livrea MA, Tesoriere L, Pintaudi AM, et al. Oxidative stress and antioxidant status in beta-thalassemia major: iron overload and depletion of lipid-soluble antioxidants. Blood. 1996;88:3608-3614.
15. Katerelos C, Constantopoulos A, Agathopoulos A, et al. Serum levels of retinol, retinol-binding protein, carotenoids and triglycerides in children with beta-thalassemia major. Acta Haematol. 1979;62:100-105.
16. Arcasoy A, Cavdar AO. Changes of trace minerals (serum iron, zinc, copper and magnesium) in thalassemia. Acta Haematol. 1975;53:341-346.
17. Tesoriere L, D'Arpa D, Maggio A, et al. Oxidation resistance of LDL is correlated with vitamin E status in beta-thalassemia intermedia. Atherosclerosis. 1998;137:429-435.
18. Jones LT. The lacrimal secretory system and its treatment. Am J Ophthalmol. 1966;62:47-60.
19. Lemp MA. Report of the National Eye Institute: industry workshop on clinical trials in dry eyes. CLAO J. 1995;21:221-232.
20. VanBijsterveld OP. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 1969;82:10-14.
21. Lakhanpal V, Schocket SS, Jiji R. Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy. Ophthalmology. 1984;91:443-451.
22. Graziano JH, Markenson A, Miller DR, et al. Chelation therapy in β-thalassemia major. Intravenous and subcutaneous deferoxamine. J Pediatr. 1978;92:648-652.
23. Olivieri NF, Buncic JR, Chew E, et al. Visual and auditory neurotoxicity in patients receiving subcutaneous desferrioxamine infusions. New Engl J Med. 1986;314:869-873.
24. Arden GB, Wonke B, Kennedy C, et al. Ocular changes in patients undergoing long-term desferrioxamine treatment. Br J Ophthalmol. 1984;68:873-877.
25. De Sanctis V, Pinamati A, Di Palma A, et al. Growth and development in thalassemia major patients with severe bone lesions due to desferrioxamine. Eur J Pediatr. 1996;155:368-372.
26. Rinaldi M, Della Corte M, Ruocco V, et al. Ocular involvement correlated with age in patients affected by major and intermedia-thalassemia treated or not with desferrioxamine. Metab Pediatr Syst Ophthalmol. 1993;16:23-25.
27. Tsubota K, Kajiwara K, Ugajin S, et al. Conjunctival brush cytology. Acta Cytol. 1990;34:233-235.
28. Tseng SC. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology. 1985;92:728-733.
29. Rivas L, Oroza MA, Perez-Esteban A, et al. Morphological changes in ocular surface in dry eyes and other disorders by impression cytology. Graefes Arch Clin Exp Ophthalmol. 1992;230:329-334.
30. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disease. Arch Ophthalmol. 1984;102:1049-1051.
31. Tseng SC, Hirst LW, Maumenee AE, et al. Possible mechanisms for the loss of goblet cells in mucin-deficient disorders. Ophthalmology. 1984;91:545-552.
32. Ralph RA. Conjunctival goblet cell density in normal subjects and in dry eye syndromes. Invest Ophthalmol. 1975;14:299-302.
33. Beitch I. The induction of keratinization in the corneal epithelium. A comparison of the "dry" and vitamin A-deficient eyes. Invest Ophthalmol. 1970;9:827-843.
34. Amemiya T. The eye and nutrition. Nippon Ganka Gakkai Zasshi. 1999;103:829-850.
35. De Luca C, Filosa A, Grandinetti M, et al. Blood antioxidant status and urinary levels of catecholamine metabolites in beta-thalassemia. Free Radic Res. 1999;30:453-462.
36. Shimmura S, Suematsu M, Shimoyama M, et al. Subthreshold UV radiation-induced peroxide formation in cultured corneal epithelial cells: the protective effects of lactoferrin. Exp Eye Res. 1996;63:519-526.
37. 3+ transport by iron-loaded cardiac myocytes. Toxicology. 1997;117:141-151.
38. Tesoriere L, D'Arpa D, Maggio A, et al. Oxidation resistance of LDL is correlated with vitamin E status in beta-thalassemia intermedia. Atherosclerosis. 1998;137:429-435.