Process development for the synthesis of 5′-O-(4,4′ -dimethoxytrityl)-N2-isobutyryl-2′-O-(2-methoxyethyl) -guanosine - A potential precursor for the second generation antisense oligonucleotides: An improved process for the preparation of 2′-O-alkyl-2,6-diaminopurine riboside

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1327-1330

  Taj, Shabbir Ali S ^a   Gurumurthy, P ^a   Suresh, R ^a   Narayanan, S ^a   Meenakshi, S Suman ^a   Sanghvi, Yogesh S ^b  

^a Shasun Chemicals and Drugs Ltd   (India)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOADENOSINE; 2,6 DIAMINOPURINE DERIVATIVE; 5' O (4,4' DIMETHOXYTRITYL) N2 ISOBUTYRYL 2' O (2 METHOXYETHYL)GUANOSINE; ANTISENSE OLIGONUCLEOTIDE; DIMETHYL SULFOXIDE; GUANOSINE DERIVATIVE; HALIDE; METHANOL; POTASSIUM HYDROXIDE; UNCLASSIFIED DRUG;

ALKYLATION; CHEMICAL MODIFICATION; CONFERENCE PAPER; CRYSTALLIZATION; DEAMINATION; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; NUCLEOTIDE METABOLISM; ROOM TEMPERATURE;

GUANOSINE; INDICATORS AND REAGENTS; OLIGORIBONUCLEOTIDES, ANTISENSE; RIBONUCLEOSIDES; RIBOSE;

EID: 0141708014     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022957     Document Type: Conference Paper

References (6)

1. Altmann, K-H.; Martin, P.; Dean, N.M.; Monia, B.P. Nucleos. & Nucleot. 1997, 16, 917-926.
2. Sanghvi, Y.S.; Andrade, M.; Deshmukh, R.R.; Holmburg, L.; Scozzari, A.N. ; Cole, D.L. Manual of Antisense Methodology; Hartmann, G., Endres, S., Eds.; Kluwer Academic Publishers, 1999; 3-23.
3. Martin, V.P. Helv. Chim. Acta. 1995, 78, 486-504.
4. Grotli, M.; Douglas, M.; Beijer, B.; Garcia, R.G.; Eritja, R.; Sproat, B. J. Chem. Soc., Perkin Trans. 1 1997, 2779-2788.
5. Beigelman, L.; Haeberli, P.; Sweedler, D.; Karpeisky, A. Tetrahedron 2000, 56, 1047-1056.
6. McGee, D.P.C. U.S. Patent 5,506,351, April 9, 1996.