Novel short oligonucleotide conjugates as inhibitors of human telomerase

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1627-1629

  Pongracz, Krisztina ^a   Li, Shihong ^a   Herbert, Brittney Shea ^b   Pruzan, Ronald ^a   Wunder, Ellen ^a   Chin, Allison ^a   Piatyszek, Mieczyslaw ^a   Shay, Jerry ^b   Gryaznov, Sergei M ^a  

^a GERON CORPORATION   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Oligonucleotide thio phosphoramidates; Telomerase inhibitors

Indexed keywords

OLIGONUCLEOTIDE; PHOSPHORAMIDIC ACID DERIVATIVE; TELOMERASE INHIBITOR;

CHEMICAL ANALYSIS; CONFERENCE PAPER; ENZYME INHIBITION; HUMAN; IC 50; RNA ANALYSIS; SYNTHESIS;

AMIDES; BASE SEQUENCE; ENZYME INHIBITORS; FLUORESCENT DYES; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; PHOSPHORIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERASE;

EID: 0141707878     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120023085     Document Type: Conference Paper

References (2)

1. Hahn, W.C.; Stewart, S.A.; Brooks, M.W.; York, S.G.; Eaton, E.; Kurachi, A.; Bejersbergen, R.L.; Knoll, J.H.; Meyerson, M.; Weinberg, R.A. Inhibition of telomerase limits the growth of human cancer cells. Nature Med. 1999, 10, 1164-1170.
2. Herbert, B-S.; Pongracz, K.; Shay, J.W.; Gryaznov, S.M. Oligonucleotide N3′ → P5′ phosphoramidates as efficient telomerase inhibitors. Oncogene 2002, 28, 638 pp.