Endothelium-dependent relaxation in response to poly-L-arginine in canine coronary arteries. Implications about hyperpolarization as a mechanism of vasodilatation;Relaxamento dependente do endotélio causado pela poli-L-arginina. Implicações sobre a hiperpolarização como mecanismo de vasodilatação

Arquivos Brasileiros de Cardiologia

Volumn 80, Issue 6, 2003, Pages 621-630

  Evora, Paulo Roberto B ^a   Pearson, Paul J ^b   Rodrigues, Alfredo José ^b   Viaro, Fernanda ^b   Schaff, Hartzell V ^b  

^a Rua Rui Barbosa 455/140   (Brazil)

^b NONE

Author keywords

EDHF; Endothelium; Nitric oxide; Poly L arginine; Polycations

Indexed keywords

ACETYLCHOLINE; CARBON DIOXIDE; EGTAZIC ACID; ENDOTHELIUM DERIVED RELAXING FACTOR; GLIBENCLAMIDE; INDOMETACIN; METHYLENE BLUE; N(G) METHYLARGININE; N(G) NITROARGININE; OUABAIN; OXYGEN; POLYARGININE; POTASSIUM CHLORIDE; PROSTAGLANDIN F2; VERAPAMIL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORONARY ARTERY; DOG; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM; FEMALE; HYPERPOLARIZATION; MALE; NONHUMAN; VASODILATATION; ANIMAL; CORONARY BLOOD VESSEL; DRUG ANTAGONISM; MUSCLE RELAXATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALS; CORONARY VESSELS; DOGS; ENDOTHELIUM, VASCULAR; FEMALE; MALE; MUSCLE RELAXATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEPTIDES; VASODILATION; VASODILATOR AGENTS;

EID: 0141705522     PISSN: 0066782X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0066-782x2003000600005     Document Type: Article

References (23)

1. Feletou M, Vanhoutte PM. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br J Pharmacol 1988;93:515-24.
2. Palmer RMJ, Ferrige AG, Moncada, S. Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature 1987;327:524-6.
3. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci USA 1987;84:9265-9.
4. Rees DD, Palmer RMJ, Hodson HF, Moncada S. A specific inhibitor of nitric oxide formation from L-arginine attenuates endothelium-dependent relaxation. Br J Pharmacol 1989;96:418-24.
5. G-nitro arginine (L-NOARG), a novel, L-arginine-reversible inhibitor of endothelium-dependent vasodilatation in vitro. Br J Pharmacol 1990;99:408-12.
6. Thomas G, Mostaghim R, Ramwell PW. Endothelium-dependent vascular relaxation by arginine containing polypeptides. Biochem Biophys Res Comm 1986;141:446-51.
7. Ignarro LJ, Gold ME, Buga GM, et al. Basic polyamino acids rich in arginine, lysine, or omithine cause both enhancement of and refractoriness to formation of endothelium-derived nitric oxide in pulmonary artery and vein. Circ Res 1989; 64:315-29.
8. Thomas G, Hecker M, Ramwell PW. Vascular activity of polycations and basic amino acids: L-arginine does not specifically elicit endothelium-dependent relaxation. Biochem Biophys Res Commun 1989;158:177-80.
9. Westergren I, Johansson BB. Altering the blood-brain barrier in the rat by intracarotid infusion of polycations: a comparison between protamine, poly-L-lysine and poly-L-arginine. Acta Physiol Scand 1993;149:99-104.
10. Coyle AJ, Uchida D, Ackerman SJ, Mitzner W, Irvin CG. Role of cationic proteins in the airway. Hyperresponsiveness due to airway inflammation. Am J Respir Crit Care Med 1994;150:S63-71.
11. Ginsburg I. Cationic polyelectrolytes: potent opsonic agents which activate the respiratory burst in leukocytes. Free Radic Res Commun 1989;8:11-26.
12. Hyslop S, de Nucci G. Heparin, polycations, and atherosclerosis. Semin Thromb Hemost 1993;19:89-98.
13. Kinoshita H, Katusic ZS. Nitric oxide and effects of cationic polypeptides in canine cerebral arteries. J Cereb Blood Flow Metab 1997;17:470-80.
14. Needham L, Hellewell PG, Williams TJ, Gordon JL. Endothelial functional responses and increased vascular permeability induced by polycations. Lab Invest 1988;59:538-48.
15. Vepa S, Scribner WM, Natarajan V. Activation of endothelial cell phospholipase D by polycations. Am J Physiol 1997;272:L608-13.
16. Alavi N. Effect ofpolycations on prostaglandin synthesis in cultured glomerular mesangial cells. Biochim Biophys Acta 1990;1042:221-6.
17. Evora, PR, Pearson PJ, Schaff HV. Impaired endothelium-dependent relaxation after coronary reperfusion injury: evidence for G-protein dysfunction. Ann Thorac Surg 1994;57:1550-6.
18. Gillespie JS, Sheng H. Influence of haemoglobin and erythrocytes on the effects of EDRF, a smooth muscle inhibitory factor, and nitric oxide on vascular smooth muscle. Br J Pharmacol 1988;95:1151-6.
19. Chen G, Hashitani H, Suzuki H. Endothelium-dependent relaxation and hyperpolarization of canine coronary artery smooth muscle in relation to the electrogenic Na-K pump. Br J Pharmacol 1989;98:950-6.
20. Hoeffner U, Feletou M, Flavahan NA, Vanhoutte PM. Canine arteries release two different endothelium-derived relaxing factors. Am J Physiol 1989;257: H330-3.
21. Ge ZD, Zhang XH, Fung PC, He GW. Endothelium-dependent hyperpolarization and relaxation resistance to N(G)-nitro-L-arginine and indomethacin in coronary circulation. Cardiovasc Res 2000;46:547-56.
22. Eckman D, Hopkins N, McBride C, Keef K. Endothelium-dependent relaxation and hyperpolarization in guinea-pig coronary artery: role of epoxyeicosatrienoic acid. Br J Pharmacol 1998;124:181-9.
23. Waldron GJ, Cole WC. Activation of vascular smooth muscle K+ channels by endothelium-derived relaxing factors. Clin Exp Pharmacol Physiol 1999;26:180-4.