Cough after inhalation of corticosteroids delivered from spacer devices in children with asthma

Fundamental and Clinical Pharmacology

Volumn 17, Issue 5, 2003, Pages 627-631

  Dubus, Jean Christophe ^a   Mély, Laurent ^a   Huiart, Laetitia ^b   Marguet, Christophe ^c   Le Roux, Pascal ^d  

^a TIMONE HOSPITAL   (France)

^b HÔPITAL SAINTE MARGUERITE   (France)

^c HÔPITAL CHARLES NICOLLE   (France)

^d LE HAVRE HOSPITAL   (France)

Author keywords

Asthma; Corticosteroids; Cough; Inhaled therapy; Spacer device

Indexed keywords

BECLOMETASONE DIPROPIONATE; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; FLUTICASONE PROPIONATE;

ADOLESCENT; ARTICLE; ASTHMA; CHILD; CONTROLLED STUDY; COUGHING; DEVICE; DISEASE SEVERITY; DRUG MEGADOSE; FACE MASK; FEMALE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; PATIENT COMPLIANCE; PHYSICIAN; PRIORITY JOURNAL; RISK FACTOR;

ADMINISTRATION, INHALATION; ADOLESCENT; ASTHMA; BECLOMETHASONE; CHI-SQUARE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; CONFIDENCE INTERVALS; COUGH; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; INFANT; MALE; METERED DOSE INHALERS;

EID: 0141705348     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1472-8206.2003.00191.x     Document Type: Article

References (19)

1. Dubus J.C., Marguet C., Deschildre A, et al. Local side-effects of inhaled corticosteroids in asthmatic children: influence of drug, dose, age, and device. Allergy (2001) 56 944-948.
2. Shim C., Williams M.H. Jr. Cough and wheezing from beclomethasone aerosol. Chest (1987) 91 207-209.
3. Hanania N.A., Chapman K.R., Kesten S. Adverse effects of inhaled corticosteroids. Am. J. Med. (1995) 98 196-208.
4. Warner J.O., Naspitz C.K. Third international pediatric consensus statement on the management of childhood asthma. Pediatr. Pulmonol. (1998) 25 1-17.
5. Williamson I.J., Matusiewicz S.P., Brown P.H., Greening A.P., Crompton G.K. Frequency of voice problems and cough in patients using pressurized aerosol steroid preparations. Eur. Respir. J. (1995) 8 590-592.
6. Charpin D., Beaupre A., Orehek J. Deep inspiration induced bronchoconstriction: a mechanism for beclomethasone aerosol intolerance. Eur. J. Respir. Dis. (1983) 64 494-497.
7. McGivern D.V., MacFarlane J.T. Severe bronchoconstriction after inhalation of budesonide. Br. Med. J. (1984) 288 447.
8. Yarbrough J., Lyndon R.N., Mansfield E., Ting S. Metered dose inhaler induced bronchospasm in asthmatic patients. Ann. Allergy (1985) 55 25-27.
9. Clark R.J. Exacerbation of asthma after nebulised beclomethasone dipropionate. Lancet (1986) ii 574-575.
10. Shim C.S., Williams M.H. Jr. Cough and wheezing from beclomethasone dipropionate aerosol are absent after triamcinolone acetonide. Ann. Intern. Med. (1987) 106 700-703.
11. Bryant D.H., Pepys J. Bronchial reactions to aerosol inhalant vehicles. Br. Med. J. (1976) i 1319-1320.
12. Sterling G.M., Batten J.C. Effect of aerosol propellants and surfactants on airway resistance. Thorax (1969) 24 228-231.
13. Charpin D., Orehek J. Reactions to bronchoconstrictor drugs. Chest (1987) 92 958.
14. Hofman W., Martonen T.B., Graham R.C. Predicted deposition of nonhydroscopic aerosols in the human lung as a function of subject age. J. Aerosol Med. (1989) 2 49-68.
15. Widdicombe J.G. Neurophysiology of the cough reflex. Eur. Respir. J. (1995) 8 1193-1202.
16. Engel T., Heinig J.H., Malling H.J., Scharling B., Nikander K., Madsen F. Clinical comparison of inhaled budesonide delivered either via pressurized metered dose inhaler or Turbuhaler®. Allergy (1989) 44 220-225.
17. Hvidoz K.M., Jarvis B. Budesonide inhalation suspension: a review of its use in infants, children and adults with inflammatory respiratory disorders. Drugs (2000) 60 1141-1178.
18. Cates C.J., Adams N., Bestall J.J. Holding chambers versus nebulisers for inhaled steroids in chronic asthma. Cochrane Database Syst. Rev. (2001) 2 CD001491.
19. Leach C. Effect of formulation parameters on hydrofluoroalkane-beclomethasone dipropionate drug deposition in humans. J. Allergy Clin. Immunol. (1999) 104 S250-252.