Caffeine and central noradrenaline: Effects on mood, cognitive performance, eye movements and cardiovascular function

Journal of Psychopharmacology

Volumn 17, Issue 3, 2003, Pages 283-292

  Smith, Andrew ^a   Brice, Carolyn ^a   Nash, Jon ^b   Rich, Neil ^b   Nutt, David J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Alertness; Caffeine; Cardiovascular function; Central noradrenaline; Clonidine; Cognitive performance; Saccadic eye movements

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; CENTRAL STIMULANT AGENT; CLONIDINE; NORADRENALIN; PLACEBO;

ADOLESCENT; ADULT; AFFECT; ALERTNESS; ARTICLE; BEHAVIOR; BLOOD PRESSURE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR SYSTEM; CHOLINERGIC ACTIVITY; CLINICAL TRIAL; COFFEE; COGNITION; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DROWSINESS; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; EYE MOVEMENT; HUMAN; HUMAN EXPERIMENT; MALE; MEMORY; MENTAL PERFORMANCE; MENTAL TASK; METABOLISM; MOOD; MOOD DISORDER; NEUROTRANSMITTER RELEASE; NORADRENALIN RELEASE; NORMAL HUMAN; PHYSIOLOGY; PRIORITY JOURNAL; SACCADIC EYE MOVEMENT; SINGLE BLIND PROCEDURE; TASK PERFORMANCE;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; ADULT; AFFECT; CAFFEINE; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM STIMULANTS; CLONIDINE; COGNITION; HUMANS; MALE; MEMORY; NOREPINEPHRINE; SACCADES;

EID: 0141704324     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/02698811030173010     Document Type: Article

References (64)

1. Baddeley A D (1968) A three-minute reasoning test based on grammatical transformation. Psychonom Sci 10: 341-342
2. Baddeley A D (1981) The cognitive psychology of everyday life. Br J Psychol 72: 257-269
3. Ball D M, Glue P, Wilson S, Nutt D J (1991) Pharmacology of saccardic eye movements in man (1): effects of the benzodiazepine recepter ligands, midazolam and flumazemil. Psychopharmacol 105: 361-367
4. Berkowitz B A, Tarver J H, Spector S (1970) Release of norepinephrine in the central nervous system by theophylline and caffeine. Eur J Pharmacol 10: 64-71
5. Berkowitz B A, Spector S, Pool W (1971) The interaction of caffeine, theophylline and theobromine with monoamine oxidase inhibitors. Eur J Pharmacol 16: 315-321
6. Bonnet M H, Arand D L (1994) The use of prophylactic naps and caffeine to maintain performance during a continuous operation. Ergonomics 37: 1009-1020
7. Brice C F, Smith A P (2001a) Caffeine levels in saliva: associations with psychosocial factors and behavioural effects. Hum Psychopharmacol Clin Exp 16: 507-521
8. Brice C F, Smith A P (2001b) The effects of caffeine on simulated driving, subjective alertness and sustained attention. Hum Psychopharmacol Clin Exp 16: 523-531
9. Brice C F, Smith A P (2002) Effects of caffeine on mood and performance: a study of realistic consumption. Psychopharmacology 164: 188-192
10. Broadbent D E (1971) Decision and stress. Academic Press, London
11. Broadbent D E, Broadbent M H P, Jones J L (1986) Performance correlates of self-reported cognitive failure and obsessionality. Br J Clin Psychol 25: 285-299
12. Broadbent D E, Broadbent M H P, Jones J L (1989) Time of day as an instrument for the analysis of attention. Eur J Cognit Psychol 1: 69-94
13. Callaway E, Halliday R, Naylor H, Brandeis D (1991) Clonidine and scopolamine: differences and similarities in how they change human information processing. Progr Neuropsychopharmacol Biol Psychiatry 15: 497-502
14. Clark C R, Geffen G M, Geffen L B (1986) Role of monoamine pathways in attention and effort: effects of clonidine and methylphenidate in normal adult humans. Psychopharmacology 90: 35-39
15. Clark C R, Geffen G M, Geffen LB (1987) Catecholamines and attention II: pharmacological studies in normal humans. Neurosci Biobehav Rev 11: 353-364
16. Clubley M, Bye C E, Henson T A, Peck A W, Riddington C J (1979) Effects of caffeine alone and in combination on human performance, subjective effects and EEG activity. Br J Clin Pharmacol 7: 157-163
17. Coull J T, Middleton H C, Robbins T W, Sahakian B J (1995) Clonidine and diazepam have differential effects on tests of attention and learning. Psychopharmacology 120: 322-332
18. Dews P B (1982) Caffeine. Ann Rev Nutrition 2: 323-341
19. Eysenck H J, Eysenck S (1968) Manual for the Eysenck personality inventory. Educational and Industrial Testing Service, San Diego
20. Ferre S, Fuxe K, von Euler G, Johansson B, Fredholm BB (1992) Adenosine-dopamine interactions in the brain. Neuroscience 51: 501-512
21. Fredholm B B, Dunwiddie T V (1988) How does adenosine inhibit transmitter release? Trends Pharmacol Sci 9: 130-134
22. Fredholm B B, Fuxe K, Agnati L (1976) Effect of phosphodiesterase inhibitors on central dopamine mechanisms. Eur J Pharmacol 38: 31-38
23. Fredholm B B, Battig K, Holmen J, Nehlig A, Zvartau E (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51: 83-133
24. Garrett B E, Griffiths R R (1997) The role of dopamine in the behavioral effects of caffeine in animals and humans. Pharmacol Biochem Behav 5: 533-541
25. Glue P, Nutt D (1988) Clonidine challenge testing of alpha-2 adrenoceptor function in man: the effects of mental illness and psychotropic medication. J Psychopharmacol 2: 119-137
26. Glue P, White F, Wilson S, Ball D M, Nutt D J (1991) Pharmacology of saccadic eye movements in man. Psychopharmacology 105: 368-373
27. Grant S J, Redmond Jr D E (1982) Methylxanthine activation of noradrenergic unit activity and reversal by clonidine. Eur J Pharmacol 85: 105-109
28. Green P J, Kirby R, Suls J (1996) The effects of caffeine on blood pressure and heart rate: a review. Ann Behav Med 18: 201-216
29. Halliday R, Callaway E, Lannon R (1989) The effects of clonidine and yohimbine on human information processing. Psychopharmacology 99: 563-566
30. Herbert M, Johns M W, Dore C (1976) Factor analysis of analogue scales measuring subjective feelings before and after sleep. Br J Med Psychol 49: 373-379
31. Horne J A, Reyner L A (1996) Counteracting driver sleepiness: Effects of napping, caffeine and placebo. Psychophysiology 33: 306-309
32. James J E (1994) Does caffeine enhance or merely restore degraded psychomotor performance? Neuropsychobiology 30: 124-125
33. James J E (1997) Understanding caffeine: a biobehavioural analysis. Sage, Thousand Oaks, CA
34. Kerr J S, Sherwood N, Hindmarsh I (1991) Separate and combined effects of the social drugs on psychomotor performance. Psychopharmacology 104: 113-119
35. Lieberman H R (1992) Caffeine. In Smith A P, Jones D M (eds), Handbook of human performance, vol. 2, pp. 49-72. Academic Press, London
36. Loke W H (1988) Effects of caffeine on mood and memory. Physiol Behav 44: 367-372
37. Lorist M M, Snel J, Kok A (1994) Influence of caffeine on information processing stages in well rested and fatigued subjects. Psychopharmacology 113: 411-421
38. Lorist M M, Snel J, Kok A, Mulder G (1996) Acute effects of caffeine on selective attention and visual search processes. Psychophysiology 33: 354-361
39. Nehlig A, Daval J, Debry G (1992) Caffeine and the central nervous system: mechanisms of action, biochemical, metabolic and psychostimulant effects. Brain Res Rev 17: 139-170
40. Pincomb G A, Lovallo W R, Passey R B, Whitsett T L, Silverstein S M, Wilson M F (1985) Effects of caffeine on vascular resistance, cardiac output, and myocardial contractility in young men. Am J Cardiol 55: 119-122
41. Rainnie D G, Grunze H C R, McCarley R W, Greene R W (1994) Adenosine inhibition of mesopontine cholinergic neurons: implications for EEG arousal. Science 263: 689-692
42. Rang H P, Dale M M, Ritter J M (1995) Pharmacology. Churchill Livingstone, Edinburgh
43. Ratliff-Crain J, O'Keeffe M K, Baum A (1989) Cardiovascular reactivity, mood and task performance in deprived and nondeprived coffee drinkers. Health Psychol 8: 427-447
44. Riedel W, Hogervorst E, Leboux R, Verhey F, van Praag H, Jolles J (1995) Caffeine attenuates scopolamine-induced memory impairment in humans. Psychopharmacology 122: 158-168
45. Roache J D, Griffiths R R (1987) Interactions of diazepam and caffeine: Behavioral and subjective dose effects in humans. Pharmacol Biochem Behav 26: 801-812
46. Schweitzer P K, Muehlbach M J, Walsh J K (1992) Countermeasures for night work performance deficits: the effect of napping or caffeine on continuous performance at night. Work Stress 6: 355-365
47. Smith A P (1995) Caffeine, caffeine withdrawal and psychomotor performance: a reply to James. Neuropsychobiology 31: 200-201
48. Smith A P (2002) Effects of caffeine on human behavior. Food Chem Toxicol 40: 1243-1255
49. Smith A P (in press) Caffeine. In Lieberman H R, Kanarek R, Prasad C (eds), Nutritional neuroscience: overview of an emerging field. Taylor & Francis, London
50. Smith A P, Nutt D J (1996) Noradrenaline and attention lapses. Nature 380: 291
51. Smith A P, Rusted J M, Eaton-Williams P, Savory M, Leathwood P (1990) Effects of caffeine given before and after lunch on sustained attention. Neuropsychobiology 23: 160-163
52. Smith A P, Kendrick A M, Maben A L (1992) Effects of breakfast and caffeine on performance and mood late in the morning and after lunch. Neuropsychobiology 26: 198-204
53. Smith A P, Brockman P, Flynn R, Maben A, Thomas M (1993) Investigation of the effects of coffee on alertness and performance and mood during the day and night. Neuropsychobiology 27: 217-223
54. Smith A P, Kendrick A, Maben A, Salmon J (1994) Effects of breakfast and caffeine on cognitive performance, mood and cardiovascular functioning. Appetite 22: 39-55
55. Smith A P, Thomas M, Perry K, Whitney H (1997) Caffeine and the common cold. J Psychopharmacol 11: 319-324
56. Smith A P, Clark R, Gallagher J (1999a) Breakfast cereal and caffeinated coffee: effects on working memory, attention, mood and cardiovascular function. Physiol Behav 67: 9-17
57. Smith A P, Sturgess W, Gallagher J (1999b) Effects of a low dose of caffeine given in different drinks on mood and performance. Hum Psychopharmacol 14: 473-482
58. Smith A P, Sturgess W, Rich N, Brice C, Collison C, Bailey J, Wilson S, Nutt D J (1999c) Effects of idazoxan on reaction times, eye movements and mood of healthy volunteers and subjects with upper respiratory tract illnesses. J Psychopharmacol 13: 145-151
59. Smith D L, Tong J E, Leigh G (1977) Combined effects of tobacco and caffeine on the components of choice reaction time, heart rate and hand steadiness. Percept Motor Skills 45: 635-639
60. Spielberger C, Gorsuch R, Lushene R E (1970) STAI Manual for the State-Trait Anxiety Inventory. Consulting Psychologists Press, Palo Alto
61. Starke K (1981) Pre-synaptic receptors. Ann Rev Pharmacol Toxicol 21: 7-30
62. Warburton D M (1995) Effects of caffeine on cognition and mood without caffeine abstinence. Psychopharmacology 119: 66-70
63. Warburton D M, Bersellini E, Sweeney E (2001) An evaluation of a caffeinated taurine drink on mood, memory and information processing in healthy volunteers without caffeine abstinence. Psychopharmacology 158: 322-328
64. Wesnes K, Warburton D M (1984) Effects of scopolamine and nicotine on human rapid information processing performance. Psychopharmacology 82: 147-150