Potential use of cyclodextrins to enhance the solubility of YM466 in aqueous solution

Drug Development and Industrial Pharmacy

Volumn 29, Issue 8, 2003, Pages 903-908

  Nakamura, Katsutoshi ^a   Tokihiro, Keiichi ^a   Motomura, Yukihisa ^a   Nishide, Satoshi ^a   Yokohama, Shigeharu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Aqueous solution; Cyclodextrin; Factor Xa; Formulation; Solubility; YM466

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; [N [(7 CARBAMIMIDOYL 2 NAPHTHYL)METHYL] N [4 [[1 (1 IMINOETHYL) 4 PIPERIDYL]OXY]PHENYL]AMINOSULFONYL]ACETIC ACID METHANESULFONATE; ALPHA CYCLODEXTRIN; ANTICOAGULANT AGENT; BETA CYCLODEXTRIN; BUFFER; CITRIC ACID; CYCLODEXTRIN; GAMMA CYCLODEXTRIN; GLYCINE; LACTIC ACID; UNCLASSIFIED DRUG; YM 466;

AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; DEGRADATION; DISSOLUTION; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY; DRUG STRUCTURE; HEATING; ROOM TEMPERATURE; SUBCUTANEOUS DRUG ADMINISTRATION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID; CYCLODEXTRINS; FACTOR XA; GLYCINE; HYDROGEN-ION CONCENTRATION; LACTIC ACID; NAPHTHALENES; PIPERIDINES; SOLUBILITY; SOLUTIONS; TEMPERATURE; WATER;

EID: 0141680623     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120024186     Document Type: Article

References (8)

1. Iwatsuki, Y.; Kaku, S.; Sakai-Moritani, Y.; Taniuchi, Y.; Mano, Y.; Usui, T.; Iizumi, Y. Antithrombotic effect of YM466, a synthesized factor Xa inhibitor, in arterio-venous shunt thrombosis model in squirrel monkeys. Jpn. J. Pharmacol. 2002, 88 (suppl 1), 76.
2. Uekama, K. Pharmaceutical applications of cyclodextrin complexations. Yakugaku Zasshi 1981, 101, 857-873.
3. Loftsson, T.; Brewster, M. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J. Pharm. Sci. 1996, 85, 1017-1025.
4. Ueda, M. Medicine and Drug Journal 2000, 36, 2763-2771.
5. Brewster, M.E.; Simpkins, J.W.; Hora, M.S.; Stern, W.C.; Boder, N. The potential use of cyclodextrins in parenteral formulations. J. Parenter. Sci. Technol. 1989, 43, 231-240.
6. Yoshida, A.; Arima, H.; Uekama, K.; Pitha, J. Pharmaceutical evaluation of hydroxyalkyl ethers of beta-cyclodextrins. Int. J. Pham. 1988, 46, 217-222.
7. Higuchi, T.; Connors, K.A. Phase-solubility techniques. Adv. Anal. Chem. Instrum. 1965, 4, 117-212.
8. Napaporn, J.; Thomas, M.; Svetic, K.; Shahrokh, Z.; Brazeau, G. Assessment of the myotoxicity of pharmaceutical buffers using an in vitro muscle model: effect of pH, capacity, tonicity, and buffer type. Pharm. Develop. Technol. 2000, 5, 123-130.