Molecular dissection of the vaccinia virus I7L core protein proteinase

Journal of Virology

Volumn 77, Issue 20, 2003, Pages 11279-11283

  Byrd, Chelsea M ^a   Bolken, Tove C ^b   Hruby, Dennis E ^a,b  

^a OREGON STATE UNIVERSITY   (United States)

^b SIGA Technologies Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CORE PROTEIN; CYSTEINE PROTEINASE; GENE PRODUCT; PROTEIN PRECURSOR; PROTEINASE; VIRUS PROTEIN;

ARTICLE; ASSAY; IN VIVO STUDY; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; VACCINIA VIRUS; VIRION; VIRUS GENE;

AMINO ACID SEQUENCE; CYSTEINE ENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; PROTEIN PRECURSORS; STRUCTURE-ACTIVITY RELATIONSHIP; VACCINIA VIRUS; VIRAL CORE PROTEINS;

EID: 0141676552     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.20.11279-11283.2003     Document Type: Article

References (16)

1. Andres, G., A. Alejo, C. Simon-Mateo, and M. L. Salas. 2001. African swine fever virus protease, a new viral member of the SUMO-1 specific-protease family. J. Biol. Chem. 276:780-787.
2. Byrd, C. M., T. C. Bolken, and D. E. Hruby. 2002. The vaccinia virus I7L gene product is the core protein proteinase. J. Virol. 76:8973-8976.
3. Chen, P. H., D. A. Ornelles, and T. Shenk. 1993. The adenovirus L3 23-kilodalton proteinase cleaves the amino-terminal head domain from cytokeratin 18 and disrupts the cytokeratin network of HeLa cells. J. Virol. 67:3507-3514.
4. Condit, R. C., A. Motyczka, and G. Spizz. 1983. Isolation, characterization, and physical mapping of temperature-sensitive mutants of vaccinia virus. Virology 128:429-443.
5. Freimuth, P., and C. W. Anderson. 1993. Human adenovirus serotype 12 virion precursors pMu and pVI are cleaved at amino-terminal and carboxyterminal sites that conform to the adenovirus 2 endoproteinase cleavage consensus sequence. Virology 193:348-355.
6. Hruby, D. E., L. A. Guarino, and J. R. Kates. 1979. Vaccinia virus replication. I. Requirement for the host-cell nucleus. J. Virol. 29:705-715.
7. Kane, E. M., and S. Shuman. 1993. Vaccinia virus morphogenesis is blocked by a temperature-sensitive mutation in the 17 gene that encodes a virion component. J. Virol. 67:2689-2698.
8. Krausslich, H. G., and E. Wimmer. 1988. Viral proteinases. Annu. Rev. Biochem. 57:701-754.
9. Li, S. J., and M. Hochstrasser. 1999. A new protease required for cell-cycle progression in yeast. Nature 398:246-251.
10. Li, S. J., and M. Hochstrasser. 2000. The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol. Cell. Biol. 20:2367-2377.
11. Raczynski, P., and R. C. Condit. 1983. Specific inhibition of vaccinia virus growth by 2′-O-methyladenosine: isolation of a drug-resistant virus mutant. Virology 128:458-462.
12. Silver, M., and S. Dales. 1982. Biogenesis of vaccina: interrelationship between post-translational cleavage, virus assembly, and maturation. Virology 117:341-356.
13. VanSlyke, J. K., S. S. Whitehead, E. M. Wilson, and D. E. Hruby. 1991. The multistep proteolytic maturation pathway utilized by vaccinia virus P4a protein: a degenerate conserved cleavage motif within core proteins. Virology 183:467-478.
14. VanSlyke, J. K., C. A. Franke, and D. E. Hruby. 1991. Proteolytic maturation of vaccinia virus core proteins: identification of a conserved motif at the N termini of the 4b and 25K virion proteins. J. Gen. Virol. 72:411-416.
15. Webster, A., R. T. Hay, and G. Kemp. 1993. The adenovirus protease is activated by virus-coded disulfide-linked peptide. Cell 72:97-104.
16. Whitehead, S., and D. E. Hruby. 1994. Differential utilization of a conserved motif for the proteolytic maturation of vaccinia virus proteins. Virology 200:154-161.