Effect of hemorrhage on medial collateral ligament healing in a mouse model

American Journal of Sports Medicine

Volumn 31, Issue 5, 2003, Pages 660-666

  Wright, Rick W ^a,b   Parikh, Manish ^a   Allen, Tracy ^a   Brodt, Michael D ^a   Silva, Matthew J ^a   Botney, Mitchell D ^a  

^a BARNES JEWISH HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; TROPOCOLLAGEN;

ANIMAL MODEL; ANIMAL TISSUE; BLEEDING; CONFERENCE PAPER; CONTROLLED STUDY; GENE EXPRESSION; HISTOLOGY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KNEE INJURY; KNEE LIGAMENT INJURY; LIGAMENT INJURY; LOADING TEST; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; WOUND HEALING;

EID: 0141656382     PISSN: 03635465     EISSN: None     Source Type: Journal    
DOI: 10.1177/03635465030310050501     Document Type: Conference Paper

References (24)

1. Anderson DR, Weiss JA, Takai S, et al: Healing of the medial collateral ligament following a triad injury: A biomechanical and histological study of the knee in rabbits. J Orthop Res 10: 485-495 1992
2. Arnoczky SP, Warren RF, Spivak JM: Meniscal repair using an exogenous fibrin clot. An experimental study in dogs. J Bone Joint Surg 70A: 1209-1217, 1988
3. Bahadori L, Milder J, Gold L, et al: Active macrophage-associated TGF-β co-localizes with type I procollagen gene expression in atherosclerotic human pulmonary arteries. Am J Pathol 146: 1140-1149, 1995
4. Botney MD, Kaiser LR, Cooper JD, et al: Extracellular matrix protein gene expression in atherosclerotic hypertensive pulmonary arteries. Am J Pathol 140: 357-364, 1992
5. Frank C, Amiel D, Akeson WH: Healing of the medial collateral ligament of the knee. A morphological and biochemical assessment in rabbits. Acta Orthop Scand 54: 917-923, 1983
6. Frank C, Woo SL, Amiel D, et al: Medial collateral ligament healing: A multidisciplinary assessment in rabbits. Am J Sports Med 11: 379-389, 1983
7. Frank CB: Ligament healing: Current knowledge and clinical applications. J Am Acad Orthop Surg 4: 74-83, 1996
8. Frank CB, Bray RC, Hart DA, et al: Soft tissue healing, in Fu FH, Harner CD, Vince KG (eds): Knee Surgery. Baltimore, Williams & Wilkins, 1994, pp 189-229
9. Gelberman RH, Amiel D, Harwood F: Genetic expression for type I procollagen in the early stages of flexor tendon healing. J Hand Surg 17A: 551-558, 1992
10. Hart DP, Dahners LE: Healing of the medial collateral ligament in rats. The effects of repair, motion, and secondary stabilizing ligaments. J Bone Joint Surg 69A: 1194-1199, 1987
11. Heldin C, Westermark B: Role of platelet-derived growth factor in vivo, in Clark RAF (ed): Molecular and Cellular Biology of Wound Repair. New York, Plenum Press, 1996, pp 249-274
12. Inoue M, Woo SL, Gomez MA, et al: Effects of surgical treatment and immobilization on the healing of the medial collateral ligament: A long-term multidisciplinary study. Connect Tissue Res 25: 13-26, 1990
13. Lechner CT, Dahners LE: Healing of the medial collateral ligament in unstable rat knees. Am J Sports Med 19: 508-512, 1991
14. Letson AK, Dahners LE: The effect of combinations of growth factors on ligament healing. Clin Orthop 308: 207-212, 1994
15. Liptay MJ, Parks WC, Mecham RP, et al: Neointimal macrophages colocalize with extracellular matrix gene expression in human atherosclerotic pulmonary arteries. J Clin Invest 91: 588-594, 1993
16. Roberts AB, Sporn MB: Transforming growth factor-beta, in Clark RAF (ed): Molecular and Cellular Biology of Wound Repair. New York, Plenum Press, 1996, pp 275-310
17. Thomopoulos S, Soslowsky LJ, Flanagan CL, et al: The effect of fibrin clot on healing rat supraspinatus tendon defects. J Shoulder Elbow Surg 11: 239-247, 2002
18. Vailas AC, Zernicke FR, Grindeland RE, et al: Suspension effects on rat femur-medial collateral ligament-tibia unit. Am J Physiol 258(3 Pt 2): R724-R728, 1990
19. Vanderby R Jr, Vailas AC, Graf BK, et al: Acute modification of biomechanical properties of the bone-ligament insertion to rat limb unweighting. FASEB J 4(8): 2499-2505, 1990
20. Weiss JA, Woo SL, Ohland KJ, et al: Evaluation of a new injury model to study medial collateral ligament healing: Primary repair versus nonoperative treatment. J Orthop Res 9: 516-528, 1991
21. Wiig ME, Amiel D, Ivarsson M, et al: Type I procollagen gene expression in normal and early healing of the medial collateral and anterior cruciate ligaments in rabbits: An in situ hybridization study. J Orthop Res 9: 374-382, 1991
22. Woo SL, Gomez MA, Sites TJ, et al: The biomechanical and morphological changes in the medial collateral ligament of the rabbit after immobilization and remobilization. J Bone Joint Surg 69A: 1200-1211, 1987
23. Wunder CC, Matthes RD, Tipton CM: Knee-ligament loading properties as influenced by gravity: I. Junction with bone of 3-G rodents. Aviat Space Environ Med 53(11): 1098-1104, 1982
24. Wunder CC, Matthes RD, Tipton CM: Knee-ligament loading properties as influenced by gravity: II. Junctional capacity vs. femur length. Aviat Space Environ Med 53(11): 1105-1111, 1982