Histamine skin test reactivity following single and multiple doses of azelastine nasal spray in patients with seasonal allergic rhinitis

Annals of Allergy, Asthma and Immunology

Volumn 91, Issue 3, 2003, Pages 258-262

  Pearlman, David S ^a   Grossman, Jay ^b   Meltzer, Eli O ^c  

^a Respiratory Institute   (United States)

^b VIVRA Research   (United States)

^c ALLERGY AND ASTHMA MEDICAL GROUP AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZELASTINE; HISTAMINE;

ADOLESCENT; ADULT; ALLERGIC RHINITIS; ALLERGY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; HUMAN; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PATCH TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN TEST; URTICARIA;

EID: 0141656346     PISSN: 10811206     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1081-1206(10)63527-2     Document Type: Article

References (21)

1. Ratner PH, Findlay SR, Hampel F, et al. A double-blind, controlled trial to assess the safety and efficacy of azelastine nasal spray in seasonal allergic rhinitis. J Allergy Clin Immunol. 1994;94:818-825.
2. Storms WW, Pearlman DS, Chervinsky P, et al. Effectiveness of azelastine nasal solution, seasonal allergic rhinitis. Ear Nose Throat J. 1994;73:382-394.
3. LaForce C, Dockhom RJ, Prenner BM, et al. Safety and efficacy of azelastine nasal spray (Astelin NS) for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 1996;76:181-188.
4. Davies RJ, Lund VJ, Harten-Ash VJ. The effect of intranasal azelastine and beclomethasone on the symptoms and signs of nasal allergy in patients with perennial allergic rhinitis. Rhinology. 1993;31:159-164.
5. Gastpar H, Nolte D, Aurich R, et al. Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis. Allergy. 1994;49:152-158.
6. Gambardella R. A comparison of the efficacy of azelastine nasal spray and loratadine tablets in the treatment of seasonal allergic rhinitis. J Int Med Res. 1993;21:268-275.
7. Banov CH, Lieberman P, et al. Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis. Ann Allergy Asthma Immunol. 2001;86:28-35.
8. Lieberman P. Preclinical evidence of azelastine hydrochloride activity. Curr Ther Res. 2002;63:556-571.
9. Shin MH, Baroody F, Proud D, et al. The effect of azelastine on the early allergic response. Clin Exp Allergy. 1992;22:289-295.
10. Ciprandi G, Pronzato C, Passalacqua G, et al. Topical azelastine reduces eosinophil activation and intercellular adhesion molecule-1 expression on nasal epithelial cells: an antiallergic activity. J Allergy Clin Immunol. 1996;98:1088-1096.
11. Long WF, Taylor RJ, Wagner CJ, et al. Skin test suppression by antihistamines and the development of subsensitivity. J Allergy Clin Immunol. 1973;76:113-117.
12. Cook TJ, MacQueen DM, Wittig HJ, et al. Degree and duration of skin test suppression and side effects with antihistamines: a double blind controlled study with five antihistamines. J Allergy Clin Immunol. 1973;51:71-77.
13. Simons FE, McMillian JL, Simons KJ. Double-blind single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole and chlorpheniramine versus placebo: suppressive effects on histamine induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunol. 1990;86:540-547.
14. Atkins P, Merton H, Karin P, et al. Azelastine inhibition of skin test reactivity in humans. J Allergy Clin Immunol. 1985;75:167.
15. Naclerio RM. The effect of antihistamines on the immediate allergic response: a comparative review. Otolaryngol Head Neck Surg. 1993;108:723-730.
16. Friedman BS, Santiago ML, Berkebile C, Metcalfe DD. Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis. J Allergy Clin Immunol. 1993;92:520-526.
17. Chanal L, Rihoux JP, Bousquet MJ. Inhibitory activity of cetirizine and azelastine on skin tests induced by histamine, substance P and allergen. J Allergy Clin Immunol. 1990;85:164. Abstract.
18. Guinnepain MT, Macquin-Mavier L, Verriere JL. Histamine skin prick tests during azelastine nasal spray treatment in healthy adults. Allergy. 1995;50:102.
19. Wolff AH, Oppenheimer J. Effect of azelastine nasal spray on cutaneous histamine response. Ann Allergy Asthma Immunol. 1998;80:84.
20. Meltzer EO, Weiler JM, Dockhorn RJ, et al. Azelastine nasal spray in the management of seasonal allergic rhinitis. Ann Allergy. 1994;72:354-359.
21. Weiler JM, Meltzer EO, Benson PM, et al. A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model. J Allergy Clin Immunol. 1994;94:972-980.