Lipase-catalyzed enantioselective acylation in a halogen free ionic liquid solvent system

Chemistry Letters

Volumn 32, Issue 7, 2003, Pages 654-655

  Itoh, Toshiyuki ^a   Ouchi, Nozomi ^a   Hayase, Shuichi ^a   Nishimura, Yoshihito ^a  

^a TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL ETHER; BORIC ACID; HALOGEN; IMIDAZOLE DERIVATIVE; SOLVENT; TRIACYLGLYCEROL LIPASE;

ACYLATION; ARTICLE; CATALYSIS; CHEMICAL REACTION; ENANTIOSELECTIVITY; ENZYME DEGRADATION; POLARIMETRY; TRANSESTERIFICATION;

EID: 0141651821     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2003.654     Document Type: Article

References (14)

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2. Reviews, see: a) "Ionic Liquids Industrial Applications to Green Chemistry," ed. by R. D. Rogers and K. R. Seddon, American Chemical Society, ACS Symposium Series 818, Oxford University Press (2002). b) "Ionic Liquids in Synthesis," ed. by P. Wassersceid and T. Welton, Wiley-VCH (2003), and references cited there.
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8. This salt was completely miscible in toluene, ether, hexane, benzene, ethyl acetate, methanol, chloroform, dichloromethane, acetonitrile, acetone, and water.
9. Novozym435 (Candida Antarctica) is now commercially available as CHIRAZYME L-2,c.-f.,C2,Iyo from Roche Molecular Biochemicals.
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13. 3 showed that ethoxyethyl group was partly replaced by 5-phenyl-1-penten-3-ol after the reaction was carried out under reduced pressure conditions.
14. The authors are grateful to Mr. Masanobu Kamori of Toyodenka Co., Ltd. for providing Toyonite.