Overexpression of bcl-2 in lymphocytes of psoriatic skin

Journal of the European Academy of Dermatology and Venereology

Volumn 17, Issue 5, 2003, Pages 538-540

  Yildiz, Leventy ^a   Baris S ^a   Senturk, N ^a   Kandemir, B ^a  

^a ONDOKUZ MAYIS UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Bcl 2; Psoriasis

Indexed keywords

PROTEIN BCL 2;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; HOSPITAL DEPARTMENT; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPHOCYTE; MALE; MEDICAL RECORD; MEDICAL SCHOOL; PATHOGENESIS; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; QUANTITATIVE ANALYSIS; SKIN BIOPSY; SKIN CELL; SKIN INFLAMMATION; TISSUE SECTION; TURKEY (REPUBLIC);

ADULT; AGED; AGED, 80 AND OVER; BIOPSY, NEEDLE; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION REGULATION; GENETIC MARKERS; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHOCYTES; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-BCL-2; PSORIASIS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY;

EID: 0141650734     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1468-3083.2003.00805.x     Document Type: Article

References (17)

1. Champ RDR. Psoriasis. In: Rook A, Wilkinson DS, Ebling FJG, editors. Textbook of Dermatology, 6th edn. Blackwell Scientific Publications, Oxford, 1998: 1589-1649.
2. Ortonne JP. Aetiology and pathogenesis of psoriasis. Br J Dermatol 1996; 135 (Suppl.49): 1-5.
3. Mountz JD, Wu J, Cheng J, Zhou T. Autoimmune disease: a problem of defective apoptosis. Arthritis Rheum 1994; 37: 1415-1420.
4. Miret C, Font J, Molina R et al. BCL-2 oncogen levels correlate with systemic lupus erythematosus disease activity. Anticancer Res 1999; 19: 3071-3076.
5. Nakamura S, Sugita M, Matoba H et al. Insufficient expression of Fas antigen on helper T cells in Behçet disease. Br J Ophthalmol 1996; 80: 174-176.
6. Senturk N, Yildiz L, Sullu Y et al. Expression of bcl-2 protein in active skin lesions of Behçet's disease. Int J Dermatol 2001; 40: 747-750.
7. Hockenbery D, Nunez G, Milliman C et al. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990; 22(348) 334-336.
8. Lu QL, Abel P, Foster CS, Lalani EN. Bcl-2: Role in epithelial differentiation and oncogenesis. Hum Pathol 1996; 27: 102-110.
9. Cotran RS, Kumar V, Collins T. Pathologic Basis of Disease, 6th edn. WB Saunders, Philadelphia, 1999: 212-214.
10. Hamzaoi A, Hamzaoi K, Kooli C et al. High levels of bcl-2 protein in the T lymphocytes of the patients with Behçet's disease. Clin Exp Rheumatol 1996; 14: 106-107.
11. Johnson R, Staiano-Coico L, Austin L et al. PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes. Photochem Photobiol 1996; 63(5): 566-571.
12. Coven TR, Walters IB, Cardinale I, Krueger JG. Photodermatol Photoimmunol Photomed 1999; 15: 22-27.
13. Ozawa M, Ferenczi K, Kikuchi T et al. 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions. J Exp Med 1999; 189 (4): 711-718.
14. Bianchi L, Farrace MG, Nini G, Piacentini M. Abnormal bcl-2 and 'tissue' transglutaminase expression in psoriatic skin. J Invest Dermatol 1994; 103: 829-833.
15. Laporte M, Galand P, Fokan D et al. Apoptosis in established and healing psoriasis. Dermatology 2000; 200: 314-316.
16. Tomkoua H, Fujimoto W, Arata J. Expression of bcl-2 antagonist bak in inflammatory and neoplastic skin diseases. Br J Dermatol 1997; 137: 703-708.
17. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995; 267: 1456-1462.