Chemo-enzymatic synthesis of 3-deoxy-β-D-ribofuranosyl purines and study of their biological properties

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 751-753

  Barai, Vladimir N ^a   Zinchenko, Anatoli I ^a   Eroshevskaya, Ludmilla A ^a   Zhernosek, Elena V ^b   Balzarini, Jan ^c   De Clercq, Erik ^c   Mikhailopulo, Igor A ^b,d  

^a INSTITUTE OF MICROBIOLOGY   (Belarus)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Belarus)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^d UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Activity; Enzymatic transglycosylation; Purine nucleosides

Indexed keywords

3 DEOXY BETA DEXTRO RIBOFURANOSYLPURINE DERIVATIVE; 3' DEOXYGUANOSINE; 9 (3 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 2 AMINO 6 OXOPURINE 3' DEOXYISOGUANOSINE; 9 (3 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 2 FLUOROADENINE; 9 (3 DEOXY BETA DEXTRO ERYTHRO PENTOFURANOSYL) 2,6 DIAMINOPURINE; ANTIRETROVIRUS AGENT; DEOXYCYTIDINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CONFERENCE PAPER; CONTROLLED STUDY; DEAMINATION; DRUG SCREENING; DRUG SYNTHESIS; GLYCOSYLATION; HUMAN; HUMAN CELL; STEREOSPECIFICITY;

ANTIVIRAL AGENTS; DEOXYRIBONUCLEOSIDES; DRUG DESIGN; GLYCOSYLATION; INDICATORS AND REAGENTS; PURINE NUCLEOSIDES; PURINE-NUCLEOSIDE PHOSPHORYLASE;

EID: 0141648429     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022626     Document Type: Conference Paper

References (4)

1. (a) Marcuccio, S.M.; Elmes, B.C.; Holan, G.; Middleton, E.J. Modified nucleosides. 2. Economical synthesis of 2′,3′-dideoxycytidine. Nucleosides & Nucleotides 1992, 11, 1695-1699;
2. (b) Sivets, G.G.; Klennitskaya, T.V.; Zhernosek, E.V.; Mikhailopulo, I.A. Synthesis of peracylated derivatives of L-ribofuranose from D-ribose and their use for the preparation of β-L-ribonucleosides. Synthesis 2002, (2), 253-259.
3. Zinchenko, A.I.; Barai, V.N.; Bokut, S.B.; Kvasyuk, E.I.; Mikhailopulo, I.A. Synthesis of 9-(β-D-arabinofuranosyl)guanine using whole cells of Escherichia coli. Appl. Microbiol. Biotechnol. 1990, 32, 658-661.
4. Zaitseva, G.V.; Zinchenko, A.I.; Barai, V.N.; Pavlova, N.I.; Boreko, E.I.; Mikhailopulo, I.A. Chemical and enzymatic synthesis and antiviral properties of 2′-deoxy-2′-fluoroguanosine. Nucleosides & Nucleotides 1999, 18 (4&5), 687-688.