Antinociceptive role of oxytocin in the nucleus raphe magnus of rats, an involvement of μ-opioid receptor

Regulatory Peptides

Volumn 115, Issue 3, 2003, Pages 153-159

  Wang, Jing Wen ^a   Lundeberg, Thomas ^b   Yu, Long Chuan ^a,b  

^a PEKING UNIVERSITY   (China)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Antinociception; Nucleus raphe magnus (NRM); Oxytocin; Oxytocin receptor; opioid receptor

Indexed keywords

BETA FUNALTREXAMINE; DELTA OPIATE RECEPTOR; DELTA OPIATE RECEPTOR ANTAGONIST; KAPPA OPIATE RECEPTOR; KAPPA OPIATE RECEPTOR ANTAGONIST; MU OPIATE RECEPTOR; NALTRINDOLE; NORBINALTORPHIMINE; OXYTOCIN; OXYTOCIN ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; INJECTION; MALE; MECHANICAL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAPHE MAGNUS NUCLEUS; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; THERMAL STIMULATION;

EID: 0141638375     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-0115(03)00152-6     Document Type: Article

References (33)

1. Millan M.J. Descending control of pain. Prog. Neurobiol. 66:2002;355-474.
2. Liu Z.J., Zhuang D.B., Lundeberg T., Yu L.C. Involvement of 5-hydroxytryptaminel A receptors in the descending anti-nociceptive pathway from periaqueductal grey to the spinal dorsal horn in tract rats, rats with inflammation. Neuroscience. 112:2002;399-407.
3. Fields H.L., Basbaum A.I. Central Nervous system mechanisms of pain modulation. Wall P.D., Melzack R. Textbook of pain. 4th ed. 1999;309-329 Churchill Livingston, Edinburgh.
4. Zhang Y.X., Lundeberg T., Yu L.C. Involvement of neuropeptide Y and Y1 receptor in antinociception in nucleus raphe magnus of rats. Regul. Pept. 95:2000;109-113.
5. Huang Y.H., Brodda-Jansen G., Lundeberg T., Yu L.C. Anti-nociceptive effects of calcitonin gene-related peptide in nucleus raphe magnus of rats, an effect attenuated by naloxone. Brain Res. 873:2000;54-59.
6. Shah Y., Dostrovsky J.O. Electrophysiological evidence for a protection of the periaqueductal gray matter to nucleus raphe magnus in cat and rat. Brain Res. 193:1980;534-538.
7. Raggenbass M. Vasopressin- and oxytocin-induced activity in the central nervous system: electrophysiological studies using in-vitro systems. Prog. Neurobiol. 64:2001;307-326.
8. Agren G., Uvnas-Moberg K., Lundeberg T. Olfactory cues from an oxytocin-injected male rat can induce antinociceptive in its cage-mates. NeuroReport. 8:1997;3073-3076.
9. Arletti R., Benelli A., Bertolini A. Influence of oxytocin on nociception and morphine antinociception. Neuropeptides. 24:1993;125-129.
10. Caron R.W., Leng G., Ludwig M., Rusell J.A. Naloxone-induced supersensitivity of oxytocin neurones to opioid antagonists. Neuropharmacology. 37:1998;887-897.
11. Ge Y., Lundeberg T., Yu L.C. Blockade effect of mu and kappa opioid antagonists on the antinociception induced by intra-periaqueductal grey injection of oxytocin in rats. Brain Res. 927:2002;204-207.
12. Robinson D.A., Wei F., Wang G.D., Li P., Kim S.J., Vogt S.K.et al. Oxytocin mediates stress-induced analgesia in adult mice. J. Physiol. 540:2002;593-606.
13. Lund I., Yu L.C., Uvnas-Moberg K., Wang J., Yu C., Kurosawa M.et al. Repeated massage-like stimulation induces long-term effects on nociception: contribution of oxytocinergic mechanisms. Eur. J. Neurosci. 16:2002;330-338.
14. Lundeberg T., Uvnasmoberg K., Agren G., Bruzelius G. Antinociceptive effects of oxytocin in rats and mice. Nurosci. Lett. 170:1994;153-157.
15. Louvel D., Delvaux M., Felez A., Fioramonti J., Bueno L., Lazorthes Y.et al. Oxytocin increases thresholds of colonic visceral perception in patients with irritable bowel syndrome. Gut. 39:1996;741-747.
16. Yang J. Intrathecal administration of oxytocin induces analgesia in low back pain involving the endogenous opiate peptide system. Spine. 19:1994;867-871.
17. Yu L.C., Hansson P., Lunderberg T. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawal responses bilaterally in rats with experimental mononeuropathy, an effect partly reversed by naloxone. Neuroscience. 71:1996;523-531.
18. Yu L.C., Lundeberg S., An H., Wang F.X., Lundeberg T. Effects of intrathecal galanin on nociceptive responses in rats with mononeuropathy. Life Sci. 64:1999;1145-1153.
19. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 3rd ed. 1998;Academic Press, Sydney.
20. Andersen L.F., Lyndrup J., Akerlund M., Melin P. Oxytocin receptor blockade: a new principle in the treatment of preterm labor. Am. J. Perinatol. 6:1989;196-199.
21. Gimpl G., Fahrenholz F. The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 2:2001;629-683.
22. Poulain D.A., Wakerley J.B. Electrophysiology of hypothalamic magnocellular neurons secreting oxytocin and vasopresin. Neuroscience. 7:1982;773-808.
23. Yoshimura R., Kimura T., Watanabe D., Kiyama H. Differential expression of oxytocin receptor mRNA in the developing rat brain. Neurosci. Res. 24:1996;291-304.
24. Ostrowski N.L. Oxytocin receptor mRNA expression in rat brain: implications for behavioral integration and reproductive success. Psychoneuroendocrinology. 23:1998;989-1004.
25. Tseng L.F. The pharmacology of opioid peptides. 1995;Harwood Academic Publishers, Singapore.
26. Dickenson A.H., Oliver J.L., Besson J.M. Role of the nucleus raphe magnus in opiate analgesia as studied by the microinjection technique in the rat. Brain Res. 170:1979;95-111.
27. Martin W.R., Eades C.G., Thompson J.A., Huppler R.E., Gilbert P.E. The effects of morphine- and nalorphine-like drugs in the nondependent and morphine-dependent chronic spinal dog. J. Pharmacol. Exp. Ther. 197:1976;517-532.
28. Gillan M.G.C., Kosterlitz H.W. Spectrum of the mu-, delta-, and kappa-binding sites in homogenates of rat brain. Br. J. Pharmacol. 77:1982;461-469.
29. Goldstein A., Naidu A. Multiple opioid receptors: ligand selectivity profiles and binding site signatures. Mol. Pharmacol. 36:1989;265-272.
30. Mansour A., Fox C.A., Akil H., Watson S.J. Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications. Trends Neurosci. 18:1995;22-29.
31. Basbaum A.I., Fields H.L. Endogenous pain control systems: brain-stem spinal pathways and endorphin circuitry. Ann. Rev. Neurosci. 7:1984;309-338.
32. Fields H.L., Heinricher M.M., Manson P. Neurotransmitters in nociceptive modulatory circuits. Ann. Rev. Neurosci. 14:1991;219-245.
33. Heinricher M.M., Morgan M.M., Fields H.L. Evidence for GABA-mediated control of putative nociceptive modulating neurons in the rostral ventromedial medulla: ionotophoresis of bicuculine climinates the off-cell pause. Somatosens. Motor Res. 8:1992;215-225.