Transmitter release deficits at the neuromuscular synapse of mice with mutations in the Cav2.1 (α1A) subunit of the P/Q-type Ca2+ channel

Annals of the New York Academy of Sciences

Volumn 998, Issue , 2003, Pages 29-32

  Plomp, J J ^a   Van Den Maagdenberg, A M ^a   Ferrari, M D ^a   Frants, R R ^a   Molenaar, P C ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Mutation; Neuromuscular junction (NMJ); P Q type Ca2+ channel

Indexed keywords

CALCIUM CHANNEL P TYPE; CALCIUM CHANNEL Q TYPE;

ANIMAL TISSUE; ATAXIA; BRAIN DISEASE; CACNA1A GENE; CALCIUM TRANSPORT; CARBOXY TERMINAL SEQUENCE; CHANNEL GATING; CONFERENCE PAPER; CONTROLLED STUDY; EPILEPSY; EPISODIC ATAXIA TYPE 2; GENE; GENE MUTATION; GENETIC CODE; INHERITANCE; MIGRAINE; MISSENSE MUTATION; MOUSE; MOUSE STRAIN; NEUROMUSCULAR JUNCTION DISORDER; NEUROMUSCULAR SYNAPSE; NEUROTRANSMITTER RELEASE; NONHUMAN; PATIENT; PRESYNAPTIC NERVE; SYMPTOM;

ANIMALIA;

EID: 0141636205     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1254.005     Document Type: Conference Paper

References (4)

1. PLOMP, J.J., A.M. VAN DEN MAAGDENBERG, P.C. MOLENAAR et al. 2001. Mutant P/Q-type calcium channel electrophysiology and migraine. Curr. Opin. Invest. Drugs 2: 1250-1260.
2. JEN, J., J. WAN, M. GRAVES et al. 2001. Loss-of-function EA2 mutations are associated with impaired neuromuscular transmission. Neurology 57: 1843-1848.
3. PLOMP, J.J., M.N. VERGOUWE, A.M. VAN DEN MAAGDENBERG et al. 2000. Abnormal transmitter release at neuromuscular junctions of mice carrying the tottering alpha(1A) Ca(2+) channel mutation. Brain 123: 463-471.
4. MAXIMOV, A., T.C. SUDHOF & I. BEZPROZVANNY. 1999. Association of neuronal calcium channels with modular adaptor proteins. J. Biol. Chem. 274: 24453-24456.