Encapsulation of protamine sulphate compacted DNA in polylactide and polylactide-co-glycolide microparticles

Journal of Controlled Release

Volumn 92, Issue 1-2, 2003, Pages 209-219

  Dunne, Mairéad ^a,c   Bibby, David C ^a,b   Jones, Joanna C ^a,d   Cudmore, Sally ^a,e  

^a ELAN PHARMACEUTICALS   (United States)

^b Alnis BioSciences Inc   (United States)

^c Carrigtwohill Co   (Ireland)

^d BRISTOL MYERS SQUIBB   (United States)

^e UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Complexation; DNA; Microparticles; PLA; PLGA

Indexed keywords

AMINES; CONDENSATION; EMULSIONS; EVAPORATION; GENES;

PROTAMINE;

DNA;

DNA; MICROSPHERE; POLYGLACTIN; POLYLACTIDE; PROTAMINE SULFATE; RESOMER;

ARTICLE; DRUG RELEASE; ENCAPSULATION; GENE TARGETING; MOLECULAR WEIGHT; PRIORITY JOURNAL;

EID: 0141629764     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00304-3     Document Type: Article

References (18)

1. Tang D.C., DeVit M., Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature. 356:1992;152-154.
2. Hassett D.E., Whitton J.L. DNA immunization. Trends Microbiol. 4:1996;307-312.
3. Donnelly J.J., Ulmer J.B., Liu M.A. DNA vaccines. Life Sci. 60:1997;163-172.
4. Wang D., Robinson D.R., Kwon G.S., Samuel J. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immunogene delivery. J. Control. Release. 57:1999;9-18.
5. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(D,L-lactide-co-glycolide): stability issues and release characteristics. J. Control. Release. 61:1999;361-374.
6. Johansen P., Men Y., Merkle H.P., Gander B. Revisiting PLA/PLGA microspheres: an analysis of their potential in parental vaccination. Eur. J. Pharm. Biopharm. 50:2000;129-146.
7. Jones D.H., Clegg J.C., Farrar G.H. Oral delivery of micro-encapsulated DNA vaccines. Dev. Biol. Stand. 92:1998;149-155.
8. Benita S. Microencapsulation Methods and Industrial Applications, Part I. Methods of Encapsulation and Advances in Production Technology. 1996;Marcel Dekker, New York.
9. Neutra M.R., Frey A., Kraehenbuhl J.P. Epithelial M cells: gateways for mucosal infection and immunization. Cell. 86:1996;345-348.
10. Neutra M.R. Current concepts in mucosal immunity. V Role of M cells in transepithelial transport of antigens and pathogens to the mucosal immune system. Am. J. Physiol. 274:1998;G785-791.
11. Eldridge J.H., Staas J.K., Tice T.R., Gilley R.M. Biodegradable poly(D,L-lactide-co-glycolide) microspheres. Res. Immunol. 143:1992;557-563.
12. Tsai J.T., Furstoss K.J., Michnick T., Sloane D.L., Paul R.W. Quantitative physical characterization of lipid-polycation-DNA lipopolyplexes. Biotechnol. Applied Biochem. 36:2002;13-20.
13. Huang L., Hung M.-C., Wagner E. Nonviral Vectors For Gene Delivery. 1999;Academic Press, San Diego, CA.
14. Lasic D.D. Liposomes in Gene Delivery. 1997;CRC Press, Boca Raton, FL.
15. Sorgi F.L., Bhattacharya S., Huang L. Protamine sulphate enhances lipid mediated gene transfer. Gene Ther. 4:1997;961-968.
16. Beck L.R., Cowsar D.R., Lewis D.H., Cosgrove R.J., Riddle C.T., Lowry S.L., Epperly T. A new long-acting injectable microcapsule system for the administration of progesterone. Fertil. Steril. 31:1979;545-551.
17. Suming L., Girod-Holland S., Vert M. Hydrolytic degradation of poly(DL-lactic acid) in the presence of caffeine base. J. Control. Release. 40:1996;41-53.
18. Bodmeier R., Oh K.H., Chen H. The effect of the addition of low molecular weight poly(DL-lactide) on drug release from biodegradable poly(DL-lactide) drug delivery systems. Int. J. Pharm. 51:1989;1-8.