Serum concentration of antiepileptic drugs: Guidelines for therapeutic monitoring and appropriate interpretation;Serumkonzentration von antiepileptika. Praktische richtlinien zur messung und sinnvollen interpretation

Nervenarzt

Volumn 70, Issue 2, 1999, Pages 172-177

  Froscher W ^a,e   Kramer G ^b   Schmidt, D ^c   Stefan, H ^d  

^a UNIVERSITY OF ULM   (Germany)

^b SWISS EPILEPSY CENTER   (Switzerland)

^c Arbeitsgruppe Epilepsieforschung   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^e Abt Neurol Epileptologie Die W   (Germany)

Author keywords

Antiepileptic drugs; Optimum serum drug concentration; Serum concentration; Therapeutic monitoring

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ETHOSUXIMIDE; FELBAMATE; GABAPENTIN; LAMOTRIGINE; MESUXIMIDE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TIAGABINE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN;

ARTICLE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG EFFICACY; DRUG MONITORING; EPILEPSY; HUMAN;

ADULT; ANTICONVULSANTS; CHILD; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; EPILEPSY; FEMALE; GERMANY; HUMANS; PREGNANCY;

EID: 0141627687     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001150050419     Document Type: Article

References (25)

1. Battino D, Buti D, Estienne M, Fazio A, Granata T, Pisani F, Rota M, Marvulli E, Avanzini G (1993) Lamotigine (Lamictal) in resistant childhood epilepsy. Epilepsia 34 [Suppl 2]:65-66
2. Buchthal F, Svensmark O (1959/1960) Aspects of the pharmacology of phenytoin (Dilantin®) and phenobarbital relevant to their dosage in the treatment of epilepsy. Epilepsia 1:373-384
3. Commission on Antiepileptic Drugs, International League Against Epilepsy (1993) Guidelines for therapeutic monitoring on antiepileptic drugs. Epilepsia 34:585-587
4. Diehl LW (1982) Aktuelle Epileptologie, 2. Aufl. Werk-Verlag Dr. E. Banaschewski, München
5. Fröscher W (1996) "Therapeutischer" Bereich der Serumspiegel der Antiepileptika. In: Fröscher W, Blankenhorn V, Neher KD, Rambeck B. Pharmakotherapie der Epilepsien. Schattauer, Stuttgart New York, S 34-60
6. Fröscher W, Eichelbaum M, Gugler R, Hildenbrand G, Penin H (1981) A prospective randomised trial on the effect of monitoring plasma anticonvulsant levels in epilepsy. J Neurol 224:193-201
7. Goggin T, Casey C, Callaghan N (1986) Serum levels of sodium valproate, phenytoin and carbamazepine and seizure control in epilepsy. Irish Med J 79:150-156
8. Gram L, Flachs H, Würtz-Jörgensen A, Parnas J, Andersen B (1979) Sodium valproate, serum level and clinical effect in epilepsy: a controlled study. Epilepsia 20:303-312
9. Jackson M, Dawson P, McCrea W (1994) The hazards of prescribing from serum levels. Serizue 3:225-233
10. Kluger G, Laub MC (1995) Lamotrigin in der Behandlung von kindlichen Epilepsien. In:Heinemann U (Hrsg) Epilepsie 94. Deutsche Sektion der Internationalen Liga gegen Epilepsie. Berlin, S 276-279
11. Krämer G (1989) Stellenwert der Plasmaspiegelbestimmung von Antiepileptika. Fortschr Neurol Psychiatr 57:411-424
12. Krämer G (1992) Vigabatrin: Wirksamkeit und Verträglichkeit bei Epilepsien im Erwachsenenalter. Akt Neurol 19[Suppl 1]:S28-S40
13. Krämer G, Bauerfeind A, Erlinger U, Wad N (1996) Valproat-Serumkonzentration konventioneller und Retard-Zubereitungen bei langfristigen Kontrollen (abstract). Epilepsieblätter 9 [Suppl]:22
14. Krämer G, Wad N, Bauerfeind A, Longatti H (1996) Carbamazepine serum concentrations. Stability under treatment with conventional and slow-release preparations (abstract). Epilepsia 37 [Suppl 4]:69
15. Kutt H, Penry JK (1974) Usefulness of blood levels of antiepileptic drugs. Arch Neurol 31:283-288
16. Levy RH, Mattson RH, Meldrum BS (eds) (1995) Antiepileptic drugs, 4th ed. Raven, New York
17. Schmidt D (1977) Die Behandlung der Epilepsien mit Hilfe der Blutspiegelbestimmung von Antiepileptika. Nervenarzt 48:183-196
18. Schmidt D, Haenel F (1984) Therapeutic plasma levels of phenytoin, phenobarbital, and carbamazepine: individual variation in relation to seizure frequency and type. Neurology 34:1252-1255
19. Sivenius J, Kälviäinen R, Ylinen A, Riekkinen P (1991) Double-blind study of gabapentin in the treatment of partial seizures. Epilepsia 32:539-542
20. Stefan H (1995) Epilepsien - Diagnose und Behandlung, 2. Aufl. Chapman & Hall, Weinheim
21. Stefan H, Burr W, Fichsel H, Fröscher W, Penin H (1984) Intensive follow-up monitoring in patients with once daily evening administration of sodium valproate. Epilepsia 25:152-160
22. The Felbamate Study Group in Lennox-Gastaut-Syndrome (Ritter FJ et al.) (1993) Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut-syndrome). N Engl J Med 328:29-33
23. Turnbull DM, Rawlins MD, Weightman D, Chadwick DW (1983) Plasma concentrations of sodium valproate: their clinical value. Ann Neurol 14:38-42
24. Wolf P (1991) Antiepileptika haben keinen therapeutischen Bereich. Dtsch Med Wochenschr 116:631-633
25. Woo E, Chan YM, Yu YL, Chan YW, Huang CY (1988) If a well-stabilized epileptic patient has a subtherapeutic antiepileptic drug level, should the dose be increased? Epilepsia 29:129-139