Kinetics of ketamine plasma and urine metabolite levels following intravenous administration in the dog

Veterinary Research Communications

Volumn 27, Issue SUPPL. 1, 2003, Pages 433-436

  Roncada, P ^a   Zaghini, A ^a   Riciputi, C ^a   Romagnoli, N ^a   Spadari, A ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Dog; Ketamine; Metabolites; Pharmacokinetics

Indexed keywords

ACEPROMAZINE; DIAZEPAM; DRUG METABOLITE; KETAMINE;

ANALYTIC METHOD; ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG HALF LIFE; DRUG TRANSFORMATION; DRUG URINE LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY DYSFUNCTION; NONHUMAN; URINARY EXCRETION; VETERINARY MEDICINE;

ANIMALIA; CANIS FAMILIARIS;

EID: 0141625876     PISSN: 01657380     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:VERC.0000014197.17284.e4     Document Type: Article

References (7)

1. Adams, H.R., 1999. Farmacia e Terapeutica Veterinaria, (Traduzione italiana della VII edizione americana, EMSI, Rome), 283-296
2. Bolze, S. and Boulieu, R., 1998. HPLC determination of ketamine, norketamine and dehydronorketamine in plasma with a high-purity reversed-phase sorbent. Clinical Chemistry, 44, 560-564
3. Gross, A.S., Nicolay, A. and Eschalier, A., 1999. Simultaneous analysis of ketamine and bupivacaine in plasma by high-performance liquid chromatography. Journal of Chromatography B, Biomedical Applications, 728, 107-115
4. Kaka, J.S. and Hayton, W.L., 1980. Pharmacokinetics of ketamine and two metabolites in the dog. Journal of Pharmacokinetics and Biopharmaceutics, 8, 193-202
5. Marquardt, D.W., 1963. An algorithm for least-squares estimation of non-linear parameters. Journal of the Society of Industrial and Applied Mathematics, 11, 431-441
6. Schwieger, I.M., Szlam, F. and Hug, C.C. Jr, 1991. The pharmacodynamics of ketamine in dogs anaesthetised with enflurane. Journal of Pharmacokinetics and Biopharmaceutics, 19, 145-156
7. Seay, S.S., Aucoin, D.P. and Tyczkowska, K.L., 1993. Rapid high-performance liquid chromatographic method for the determination of ketamine and its metabolite dehydronorketamine in equine serum. Journal of Chromatography, 620, 281-287