Pediatric seizures and their management in the emergency department

Clinical Pediatric Emergency Medicine

Volumn 4, Issue 3, 2003, Pages 195-206

  Freedman, Stephen B ^a,b   Powell, Elizabeth C ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; ANTIPYRETIC AGENT; BENZODIAZEPINE DERIVATIVE; CARBAMAZEPINE; DIAZEPAM; ETHOSUXIMIDE; FOSPHENYTOIN SODIUM; IBUPROFEN; LORAZEPAM; MIDAZOLAM; PARACETAMOL; PENTOBARBITAL; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; PROPOFOL; VALPROIC ACID;

ABSENCE; AGE; ANAMNESIS; APNEA; ASYSTOLE; BACTERIAL INFECTION; BRADYCARDIA; BRAIN FUNCTION; CARDIOVASCULAR SYMPTOM; CHILD; CLINICAL EXAMINATION; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC TEST; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE COURSE; DOSE RESPONSE; DRUG EFFICACY; DRUG METABOLISM; ELECTROENCEPHALOGRAM; ELECTROLYTE DISTURBANCE; EMERGENCY WARD; EPILEPSY; EPILEPTIC STATE; FEBRILE CONVULSION; FEMALE; FEVER; FOCAL EPILEPSY; HEART ARRHYTHMIA; HIGH RISK PATIENT; HUMAN; HYPOGLYCEMIA; HYPOTENSION; MALE; MYOCARDIAL DISEASE; PATIENT CARE; PHYSICAL EXAMINATION; RESPIRATION DEPRESSION; RESPIRATORY DISTRESS; REVIEW; SEDATION; SEIZURE; SOMNOLENCE; SYMPTOMATOLOGY; TONIC CLONIC SEIZURE; TREATMENT PLANNING;

EID: 0141618349     PISSN: 15228401     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1522-8401(03)00059-4     Document Type: Article

References (88)

1. Kotagal P, Costa M, Wyllie E, et al: Paroxysmal nonepileptic events in children and adolescents. Pediatrics 110:e46, 2002.
2. Wieling W, Smit AA, van Steenwijk CC, et al: Pathophysiological mechanisms underlying vasovagal syncope in young subjects. Pacing Clin Electrophysiol 20:2034-2038, 1997.
3. Bell MR, Kozak RJ: Seizures and the long-QT syndrome. Ann Emerg Med 28:556-560, 1996.
4. Harbison JNJ, Seifer C, Kenny RA: Stokes Adams attacks and cardiovascular syncope. Lancet 359:158-160, 2002.
5. Bridge E, Livingston S, Tietze C: Breath holding spells: Their relationship to syncope, convulsions, and other phenomena. J Pediatr 23:539-561, 1943.
6. Lombroso CT, Lerman P: Breathholding spells (cyanotic and pallid infantile syncope). Pediatrics 39: 563-581, 1967.
7. Livingston S: Breathholding spells in children. JAMA 212:2231-2235, 1970.
8. DiMario FJ: Breath-holding spells in childhood. AJDC 146:125-131, 1992.
9. Blum NJ, Carey WB: Sleep problems among infants and young children. Pediatr Rev 17:87-92, 1996.
10. Kotagal S, Kristyna MH, Walsh JK: Characteristics of narcolepsy in preteenaged children. Pediatrics 85:205-209, 1990.
11. Wise MS: Childhood narcolepsy. Neurology 50:37-42, 1998.
12. Guilleminault C: Narcolepsy in prepubertal children. Ann Neurol 43:135-142, 1998.
13. Farrell PA, Weiner GM, Lemons JA: SIDS, ALTE, apnea, and the use of home monitors. Pediatr Rev 23:3-9, 2002.
14. Hoffman HJ, Damus K, Hillman L, et al: Results of the National Institute of Child Health and Human Development SIDS cooperative epidemiological study. Ann N Y Acad Sci 533:13-30, 1988.
15. Gray C, Davies F, Molyneux E: Apparent life-threatening events presenting to a pediatric emergency department. Pediatr Emerg Care 15:195-199, 1999.
16. Gallick TA, Spinks IP, King DW: Pseudoseizures: Ictal phenomena. Neurology 32:24-30, 1982.
17. Selbst SM, Clancy R: Pseudoseizures in the pediatric emergency department. Pediatr Emerg Care 12:185-188, 1996.
18. Holmes GL, Sackellares JC, McKiernan J, et al: Evaluation of childhood pseudoseizures using EEG telemetry and video tape monitoring. J Pediatr 97:554-558, 1980.
19. Gates JR, Ramani V, Whalen S, et al: Ictal characteristics of pseudoseizures. Arch Neurol 42:1183-1187, 1985.
20. King DW, Gallagher BB, Murvin AJ, et al: Pseudoseizures: Diagnostic evaluation. Neurology 32:18-23, 1982.
21. Mei-Zahav M, Uziel Y, Raz J, et al: Convulsions and retinal haemorrhage: Should we look further? Arch Dis Child 86:334-335, 2002.
22. Hirtz D, Ashwal S, Berg A, et al: Practice parameter: Evaluating a first nonfebrile seizure in children: Report of the quality standards subcommittee of the American Academy of Neurology, the Child Neurology Society, and the American Epilepsy Society. Neurology 55:616-623, 2000.
23. Smith RA, Martland T, Lowry MF: Children with seizures presenting to accident and emergency. J Accid Emerg Med 13:54-58, 1996.
24. Nypaver MM, Reynolds SL, Tanz RR, et al: Emergency department laboratory evaluation of children with seizures: Dogma or dilemma? Pediatr Emerg Care 8:13-16, 1992.
25. Bui TT, Delgado CA, Simon HK: Infant seizures not so infantile: First-time seizures in children under six months of age presenting to the ED. Am J Emerg Med 20:518-520, 2002.
26. Scarfone RJ, Pond K, Thompson K, et al: Utility of laboratory testing for infants with seizures. Pediatr Emerg Care 16:309-312, 2000.
27. Sugarman JM, Rodgers GC, Paul RI: Utility of toxicology screening in a pediatric emergency department. Pediatr Emerg Care 13:194-197, 1997.
28. American Academy of Neurology: Practice parameter: Lumbar puncture. Neurology 43:625-627, 1993.
29. Sharma S, Riviello JJ, Harper MB, et al: The role of emergent neuroimaging in children with new-onset afebrile seizures. Pediatrics 111:1-5, 2003.
30. Maytal J, Krauss JM, Novak G, et al: The role of brain computed tomography in evaluating children with new onset of seizures in the emergency department. Epilepsia 41:950-954, 2000.
31. Garvey MA, Gaillard WD, Rusin JA, et al: Emergency brain computed tomography in children with seizures: Who is most likely to benefit? J Pediatr 133:664-669, 1998.
32. McAbee GN, Barasch ES, Kurfist LA: Results of computed tomography in "neurologically normal" children after initial onset of seizures. Pediatr Neurol 5:102-106, 1989.
33. Warden CR, Brownstein DR, Del Beccaro MA: Predictors of abnormal findings of computed tomography of the head in pediatric patients presenting with seizures. Ann Emerg Med 29:518-523, 1997.
34. Berg AT, Testa FM, Levy SR, et al: Neuroimaging in children with newly diagnosed epilepsy: A community-based study. Pediatrics 106:527-532, 2000.
35. Gilman S: Imaging the brain. N Engl J Med 338: 812-820, 1998.
36. Reuter D, Brownstein D: Common emergent pediatric neurologic problems. Emerg Med Clin North Am 20:155-176, 2002.
37. Martinovic Z, Jovic N: Seizure recurrence after a first generalized tonic-clonic seizure, in children, adolescents and young adults. Seizure 6:461-465, 1997.
38. Shinnar S, Kang H, Berg AT, et al: EEG abnormalities in children with a first unprovoked seizure. Epilepsia 35:471-476, 1994.
39. Alehan FK, Morton LD, Pellock JM: Utility of electroencephalography in the pediatric emergency department. J Child Neurol 16:484-487, 2001.
40. Brodie MJ, Dichter MA: Anitepileptic drugs. N Engl J Med 334:168-175, 1996.
41. Verity CM, Golding J: Risk of epilepsy after febrile convulsions. Br Med J 303:1373-1376, 1991.
42. Trainor JL, Hampers LC, Krug SE, et al: Children with first-time simple febrile seizures are at low risk of serious bacterial illness. Acad Emerg Med 8:781-787, 2001.
43. Shah SS, Alpern ER, Zwerling L, et al: Low risk of bacteremia in children with febrile seizures. Arch Pediatr Adolesc Med 156:469-472, 2002.
44. Teach SJ, Geil PA: Incidence of bacteremia, urinary tract infections, and unsuspected bacterial meningitis in children with febrile seizures. Pediatr Emerg Care 15:9-12, 1999.
45. Green SM, Rothrock SG, Clem KJ: Can seizures be the sole manifestation of meningitis in febrile children? Pediatrics 92:527-534, 1993.
46. Committee on Quality Improvement of the American Academy of Pediatrics: Practice Parameter: Long-term treatment of the child with simple febrile seizures. Pediatrics 103:1-7, 1999.
47. Rosman N, Colton T, Labazzo J: A controlled trial of diazepam administered during febrile illness to prevent recurrence of febrile seizures. N Engl J Med 329:79-84, 1993.
48. Autret E, Billard C, Betrand P, et al: Double-blind randomized trial of diazepam versus placebo for prevention of recurrence of febrile seizure. J Pediatr 117:490-494, 1990.
49. Baumann R: Technical report: Treatment of the child with simple febrile seizure. Pediatrics 103:1-5, 1999.
50. Berg AT, Shinnar S, Hauser WA, et al: A prospective study of recurrent febrile seizures. N Engl J Med 327:1122-1127, 1992.
51. Berg AT, Shinnar S, Darefsky AS, et al: Predictors of recurrent febrile seizures. A prospective cohort study. Arch Pediatr Adolesc Med 151:371-378, 1997.
52. Mizrahi EM: Neonatal seizures and neonatal epileptic syndromes. Neurologic Clinics Vol 19. Philadelphia, PA, W.B. Saunders Co, 2001.
53. Massingale TW, Buttross S: Survey of treatment practices for neonatal seizures. J Perinatol 13:107-110, 1993.
54. Morton LD, Pellock JM, Gilman JT: Fosphenytoin safety and pharmokinetics in children. Epilepsia 38 (suppl 8):194, 1997.
55. Lewis RJ, Yee L, Inkelis SH, et al: Clinical predictors of post-traumatic seizures in children with head trauma. Ann Emerg Med 22:1114-1118, 1993.
56. Annegers JF, Hauser AW, Coan SP, et al: A population-based study of seizures after traumatic brain injury. N Engl J Med 338:20-24, 1998.
57. Pellock JM: Status epilepticus in children: Update and review. J Child Neurol 9 (Suppl 2):27-35, 1994.
58. Maytal J, Shinnar S, Moshe SL, et al: Low morbidity and mortality of status epilepticus in children. Pediatrics 83:323-331, 1989.
59. Hauser WA: Status epilepticus: Epidemiologic considerations. Neurology 40 (suppl 2):9-13, 1990 .
60. DeLorenzo RJ, Pellock JM, Towne AR, et al: Epidemiology of status epilepticus. J Clin Neurophysiol 12: 316-325, 1995.
61. Gastaut H: Dictionary of Epilepsy. Geneva, World Health Organization, 1973.
62. Working Group on Status Epilepticus: Treatment of convulsive status epilepticus: Recommendations of the Epilepsy Foundation of America's working group on status epilepticus. JAMA 270:854-859, 1993.
63. Chiulli DA, Terndrup TE, Kanter RK: The influence of diazepam or lorazepam on the frequency of endotracheal intubation in childhood status epilepticus. J Emerg Med 9:13-17, 1991.
64. Appleton R, Sweeney A, Choonara I, et al: Lorazepam versus diazepam in the acute treatment of epileptic seizures and status epilepticus. Dev Med Child Neurol 37:682-688, 1995.
65. Alldredge BK, Gelb AM, Isaacs SM, et al: A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilepticus. N Engl J Med 345:631-637, 2001.
66. Smith BJ: Treatment of status epilepticus. Epilepsy 19:347-369, 2001.
67. Pellock JM: Management of acute seizure episodes. Epilepsia 39 (Suppl 1):28-35, 1998.
68. Dieckmann RA: Rectal diazepam for prehospital pediatric status epilepticus. Ann Emerg Med 23:216-224, 1994.
69. Chamberlain JM, Altieri MA, Futterman C, et al: A prospective, randomized study comparing intramuscular midazolam with intravenous diazepam for the treatment of seizures in children. Pediatr Emerg Care 13:92-94, 1997.
70. Scott RC, Besag FM, Neville BG: Buccal midazolam and rectal diazepam for treatment of prolonged seizures in childhood and adolescence: A randomized trial. Lancet 353:623-626, 1999.
71. Lahat E, Goldman M, Barr J, et al: Intranasal midazolam for childhood seizures. Lancet 352:620, 1998.
72. Wilder BJ: Use of parenteral antiepileptic drugs and the role of fosphenytoin. Epilepsia 46(Suppl 1):1-2, 1996.
73. Morton LD: Clinical experience with fosphenytoin in children. J Child Neurol 13 (Suppl 1):19-22, 1998.
74. Fierro LS, Savulich DH, Benezra DA: Safety of fosphenytoin sodium. Am J Health Syst Pharm 53:2707-2712, 1996.
75. Marchetti A, Magar R, Fischer J, et al: A pharmacoeconomic evaluation of intravenous fosphenytoin (Cerebyx) versus intravenous phenytoin (Dilantin) in hospital emergency departments. Clin Ther 18:953-966, 1996.
76. Bebin EM: Additional modalities for treating acute seizures in children: Overview. J Child Neurol 13 (Suppl 1):23-26, discussion 30-32, 1998.
77. Haafiz A, Kissoon N: Status epilepticus: Current concepts. Pediatr Emerg Care 15:119-129, 1999.
78. Van Ness PC: Pentobarbital and EEG burst suppression in treatment of status epilepticus refractory to benzodiazepines and phenytoin. Epilepsia 31:61-67, 1990.
79. Mitchell WG: Status epilepticus and acute repetitive seizures in children, adolescents, and young adults: Etiology, outcome, and treatment. Epilepsia 37 (Suppl 1):74-80, 1996.
80. Roberts MR, Eng-Bourquin J: Status epilepticus in children. Emerg Med Clin North Am 13:489-507, 1995.
81. Hanhan UA, Fiallos MR, Orlowski JP: Status epilepticus. Pediatr Clin North Am 48:683-694, 2001.
82. Parent JM, Lowenstein DH: Treatment of refractory generalized status epilepticus with continuous infusion of midazolam. Neurology 44:1837-1840, 1994.
83. Kumar A, Bleck TP: Intravenous midazolam for the treatment of refractory status epilepticus. Crit Care Med 20:483-488, 1992.
84. Rivera R, Segnini M, Baltodano A, et al: Midazolam in the treatment of status epilepticus in children. Crit Care Med 21:991-994, 1993.
85. Koul RL, Aithala GR, Chacko A, et al: Continuous midazolam infusion as treatment of status epilepticus. Arch Dis Child 76:445-448, 1997.
86. Uberall MA, Trollmann R, Wunsiedler U, et al: Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology 54:2188-2189, 2000.
87. Cascino GD: Nonconvulsive status epilepticus in adults and children. Epilepsia 34 (Suppl 1):21-28, 1993.
88. Quality Standards Subcommittee of the American Academy of Neurology in cooperation with American College of Emergency Physicians, American Association of Neurological Surgeons, and American Society of Neuroradiology: Practice parameter: Neuroimaging in the emergency patient presenting with seizure-summary statement. Neurology 47:288-291, 1996.