Fungal colonization in neutropenic patients: A randomized study comparing itraconazole solution and amphotericin B solution

Annals of Hematology

Volumn 82, Issue 9, 2003, Pages 565-569

  Lass Flörl, Cornelia ^a   Gunsilius, E ^b   Gastl, G ^b   Englisch, M ^a   Koch, G ^b   Ulmer, H ^a   Dierich, M P ^a   Petzer, A ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

Author keywords

Candida; Fungal colonization; Itraconazole; Prevention

Indexed keywords

AMPHOTERICIN B; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CYTOTOXIC AGENT; ITRACONAZOLE;

ADULT; ARTICLE; CANDIDA ALBICANS; CANDIDA GLABRATA; CANDIDA KRUSEI; CANDIDIASIS; CLINICAL TRIAL; COLONY FORMATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FUNGAL STRAIN; GENOTYPE; HEMATOLOGIC MALIGNANCY; HISTOPATHOLOGY; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; MYCOSIS; NEUTROPENIA; NONHUMAN; OROPHARYNX; PATHOGENESIS; PRIORITY JOURNAL; RANDOM AMPLIFIED POLYMORPHIC DNA; RANDOMIZED CONTROLLED TRIAL; RECTUM MUCOSA; SEROPREVALENCE; STRAIN DIFFERENCE; THRUSH;

AMPHOTERICIN B; ANTIFUNGAL AGENTS; ANTINEOPLASTIC AGENTS; CANDIDA; CANDIDIASIS; GENOTYPE; HEMATOLOGIC NEOPLASMS; ITRACONAZOLE; NEUTROPENIA; OROPHARYNX; RANDOM AMPLIFIED POLYMORPHIC DNA TECHNIQUE; RECTUM;

EID: 0141617351     PISSN: 09395555     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00277-003-0666-5     Document Type: Article

References (24)

1. Denning D, Legrand P, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Cantanzaro A (1994) NIAID Mycosis Study Group multicenter trial of oral itraconazole therapy for invasive aspergillosis. Am J Med 97:135-144
2. Denning DW (1991) Epidemiology and pathogenesis of systemic fungal infections in the immunocompromised host. J Antimicrob Chemother 28 [Suppl B]:1-16
3. Bodey GP, Bueltmann B, Duguid W, Gibbs D, Hanak H, Hotchi M, Mall G, Martino P, Meunier F, Milliken S (1992) Fungal infections in cancer patients: an international autopsy study. Eur J Clin Microbiol Infect Dis 11:99-109
4. Kullberg B, Lashof O (2002) Epidemiology of opportunistic invasive mycoses. Eur J Med Res 7:183-191
5. Pfaffenbach B, Donhuijsen K, Pahnke J, Bug R, Adamek RJ, Wege M, Ricken D (1994) Systemic fungal infections in hematologic neoplasms. An autopsy study of 1053 patients. Med Klin 89:299-304
6. Anaissie E, Bodey GP (1989) Nosocomial fungal infections. Old problems and new challenges. Infect Dis Clin North Am 3:867-882
7. Inoue S, Wirman JA, Alexander JW, Trocki O, Cardell RR (1988) Candida albicans translocation across the gut mucosa following burn injury. J Surg Res 44:479-492
8. Goodman JL, Winston DJ, Greenfield RA, Chandrasekar PH, Fox B, Kaizer H, Shadduck RK, Shea TC, Stiff P, Friedman DJ, Powderly WG, Silber J, Horowitz H, Lichtin A (1992) A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation. N Engl J Med 326:845-851
9. Meunier F (1987) Prevention and mycoses in immunocompromised patients. Rev Infect Dis 9:408-416
10. Winston DJ, Chandrasekar PH, Lazarus HM, Goodman JL, Silber JL, Horowitz H, Shadduck RK, Rosenfeld CS, Ho WG, Islam MZ, Buell DN (1993) Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Ann Intern Med 118:495-503
11. Harousseau J, Dekker AW, Stamatoullas-Bastard A, Fassas A, Linkesch W, Gouveia J, DeBock R, Rovira M, Seifert WF, Joosen H, Peeters M, DeBeule K (2000) Itraconazole oral solution for primary prophylaxis of fungal infections in patients wit hematological malignancy and profound neutropenia: a randomized, double-blind, double placebo, multicenter trial comparing itraconazole and amphotericin B. Antimicrob Agents Chemother 44:1887-1893
12. Böhme A, Just-Nübling G, Bergman L, Shah PM, Stille W, Hoelzer D (1996) Itraconazole for prophylaxis of systemic mycoses in neutropenic patients with hematological malignancies. J Antimicrob Chemother 38:953-961
13. National Committee for Clinical Laboratory Standards (1997) Reference method for broth dilution antifungal susceptibility testing of yeasts. Approved standard M27-A. NCCLS, Villanova, PA, USA
14. Metzgar D, van Belkum A, Field D, Haubrich R, Wills C (1998) Random amplification of polymorphic DNA and microsatellite genotyping of pre- and posttreatment isolates of Candida spp. from human immunodeficiency virus-infected patients on different fluconazole regimens. J Clin Microbiol 36:2308-2313
15. Glasmacher A, Hahn C, Molitor E, Sauerbruch T, Schmidt-Wolf I, Marklein G (1999) Fungal surveillance cultures during antifungal prophylaxis with itraconazole in neutropenic patients with acute leukaemia. Mycoses 42:395-402
16. Vreugdenhil G, Van Dijke J, Donnelly JP, Novakova IR, Raemaekers JM, Hoogkamp-Korstanje JA, Koster M, de Bauw BE (1993) Efficacy of itraconazole in the prevention of fungal infections among neutropenic patients with hematologic malignancies and intensive chemotherapy. A double blind, placebo controlled study. Leuk Lymphoma 11:353-358
17. Beck-Sague CM, Jarvis WR (1993) Secular trends in the epidemiology of nosocomial fungal infections in the United States, 1980-1990. The National Nosocomial Infections Surveillance System. J Infect Dis 167:1247-1251
18. Nucci M, Anaissie, E (2001) Revisiting the source of candidemia: skin or gut? Clin Infect Dis 33:1959-1967
19. Cole G, Halawa A, Anaissie E (1996) The role of gastrointestinal tract in hematogenous candidiasis: from the laboratory to the bedside. Clin Infect Dis 22 [Suppl. 2]:73-88
20. Bjorson H, Colley R, Bower R, Duty V, Schwartz-Fulton J, Fischer J (1982) Association between microorganism growth at the catheter insertion site and colonization of the catheter in patients receiving total parenteral nutrition. Surgery 92:720-727
21. Marr K, Seidel K, White T, Bowden R (2000) Candidemia in allogeneic blood and marrow transplant recipients: evolution of risk factors after adoption of prophylactic fluconazole. J Infect Dis 181:309-316
22. Lass-Flörl C, Nagl M, Speth C, Ulmer H, Dierich MP, Würzner R (2001) Studies of in vitro activities of voriconazole and itraconazole against Aspergillus hyphae using viability staining. Antimicrob Agents Chemother 45:124-128
23. Menichetti F, Del Favero A, Martino P, Bucaneve G, Micozzi A, Girmenia C, Barbabietola G, Pagano L, Leoni P, Specchia G, Caiozzo A, Raimondi R, Mandelli F (1999) Itraconazole oral solution as prophylaxis for fungal infections in neutropenic patients with hematologic malignancies: a randomized, placebo-controlled, double-blind, multicenter trial. Clin Infect Dis 28:250-255
24. Glasmacher A, Hahn C, Leutner C, Molitor E, Wardelmann E, Losem C, Sauerbruch T, Marklein G, Schmidt-Wolf I (1999) Breakthrough invasive fungal infections in neutropenic patients after prophylaxis with itraconazole. Mycoses 42:443-451