Inactivation of reporter genes by cloned heterochromatic repeats of Drosophila melanogaster is accompanied by chromatin compaction

Genetika

Volumn 39, Issue 5, 2003, Pages 682-686

  Naumova, N M ^a   Olenkina, O M ^a   Gvozdev, V A ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLTRANSFERASE; DNA;

ARTICLE; CHROMATIN; CLONING; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; GENE; GENE INACTIVATION; HETEROCHROMATIN; METHYLATION; MINI WHITE GENE; NONHUMAN; NUCLEOSOME; REPORTER GENE; ANIMAL; BACTERIAL GENE; CHEMISTRY; DNA METHYLATION; GENE SILENCING; GENETICS; METABOLISM; NUCLEOTIDE REPEAT;

DROSOPHILA MELANOGASTER; ESCHERICHIA COLI;

ANIMALS; CHROMATIN; DNA; DNA METHYLATION; DROSOPHILA MELANOGASTER; ESCHERICHIA COLI; GENE SILENCING; GENES, BACTERIAL; GENES, INSECT; GENES, REPORTER; HETEROCHROMATIN; METHYLTRANSFERASES; REPETITIVE SEQUENCES, NUCLEIC ACID;

EID: 0141610656     PISSN: 00166758     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Zhimulev I.F. Advances in Genetics. N.Y.: Acad. Press, 1998. 566 p.
2. Henikoff S. Gene silencing in Drosophila // Curr. Top. Microbiol. Immunol. 1995. V. 197. P. 193-208.
3. Henikoff S. Heterochromatin function in complex genomes // Biochim. Biophys. Acta. 2000. V. 1470. P. 1-8.
4. Belyaeva E.S., Demakova O.V., Umbetova G.H. et al. Cytogenetic and molecular aspects of position effect variegation in Drosophila melanogaster. V. Heterochromatin-associated protein HP1 appears in euchromatin chromosome regions inactivated as a result of position effect variegation // Chromosoma. 1993. V. 102. P. 583-590.
5. Ananiev E.V., Gvozdev V.A. Changed pattern of transcription and replication in polytene chromosomes of Drosophila melanogaster resulting from eu-heterochromatin rearrangement // Chromosoma. 1974. V. 45. P. 173-191.
6. Locke J., Kotarski M. A., Tartof K. D. Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect // Genetics. 1988. V. 120. P. 181-198.
7. Wallrath L., Elgin S. Position effect variegation in Drosophila is associated with an altered chromatin structure // Genes Dev. 1995. V. 9. P. 1263-1277.
8. Sun F.L., Cuaycong M.H., Elgin S.C. Long-range nucleosome ordering is associated with gene silencing in Drosophila melanogaster pericentric heterochromatin // Mol. Cell. Biol. 2001. V. 21. P. 2867-2879.
9. Boivin A., Dura J. M. In vivo chromatin accessibility correlates with gene silencing in Drosophila // Genetics. 1998. V. 150. P. 1539-1549.
10. Elgin S., Granok H., Lu Q. et al. Role of chromatin structure in regulating gene expression: the hsp26 gene of Drosophila melanogaster // Cold. Spring. Harb. Symp. Quant. Biol. 1993. V. 58. P. 83-96.
11. Locke J. Examination of DNA sequences undergoing chromatin conformation changes at a variegating breakpoint in Drosophila melanogaster // Genetica. 1993. V. 92. P. 33-41.
12. Schlossherr J., Eggert H., Paro R. et al. Gene inactivation in Drosophila mediated by the Polycomb gene product or by position-effect variegation does not involve major changes in the accessibility of the chromatin fibre // Mol. Gen. Genet. 1994. V. 243. P. 453-462.
13. Hayashi S., Ruddell A., Sinclair D. et al. Chromosomal structure is altered by mutations that suppress or enhance position effect variegation // Chromosoma. 1990. V. 99. P. 391-400.
14. Tulin A.V., Kogan G.L., Filipp D. et al. Heterochromatic Stellate gene cluster in Drosophila melanogaster: structure and molecular evolution // Genetics. 1997. V. 146. P. 253-262.
15. Tulin A.V., Naumova N.M., Aravin A.A. et al. Repeated, protein-encoding heterochromatic genes cause inactivation of a juxtaposed euchromatic gene // FEBS Letters. 1998. V. 425. P. 513-516.
16. Livak K. Detailed structure of the Drosophila melanogaster Stellate genes and their transcripts // Genetics. 1990. V. 124. P. 303-316.
17. Bozzetti M.P., Massari S., Finelli P. et al. The Ste locus, a component of the parasitic cry-Ste system of Drosophila melanogaster, encodes a protein that forms crystal in primary spermatocytes and mimics properties of the beta subunit of casein kinase 2 // Proc. Natl Acad. Sci. USA. 1995. V. 92. P. 6067-6071.
18. Gvozdev V. A., Kogan G. L., Titlin A. V. et al. Paralogous Stellate and Su(Ste) repeats: evolution and ability to silence a reporter gene // Genetica. 2000. V. 109. No 1-2. P. 131-140.
19. Lu Q., Wallrath L.L., Elgin S.C. Nucleosome positioning and gene regulation // J. Cell. Biochem. 1994. V. 55. P. 83-92.
20. Gottschling D.E. Telomere-proximal DNA in Saccharomyces cerevisiae is refractory to methyltransferase activity in vivo // Proc. Natl Acad. Sci. USA. 1992. V. 89. P. 4062-4065.