Design and synthesis of novel 2,7-dialkyl substituted 5(S)-amino-4(S)-hydroxy-8-phenyl-octanecarboxamides as in vitro potent peptidomimetic inhibitors of human renin

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 21, 1997, Pages 2735-2740

  Göschke, Richard ^a,b   Cohen, Nissim Claude ^a,c   Wood, Jeanette M ^a   Maibaum, Jürgen ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Technology Park Malha ^*  (Switzerland)

^c Synergix Ltd   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

5(S) AMINO 4(S) HYDROXY 8 PHENYL OCTANECARBOXAMIDE DERIVATIVE; RENIN; RENIN INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SYNTHESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

EID: 0141608479     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10067-1     Document Type: Article

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