In vivo measurements of penetration depth, oxygenation, and drug concentration using broadband absorption spectroscopy in human tissues before and after photodynamic therapy

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 4952, Issue , 2003, Pages 68-75

  Wang, Hsing Wen ^a   Zhu, Tim C ^a   Solonenko, Michael ^a   Hahn, Stephen M ^a   Metz, James ^a   Dimofte, Andreea ^a   Mile, Jermy ^a   Yodh, Arjun G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Broadband absorption spectroscopy; Diffuse photon density wave spectroscopy; Photodynamic therapy

Indexed keywords

ABSORPTION SPECTROSCOPY; LIGHT SCATTERING; PHOTODETECTORS; PHOTOSENSITIZERS; TISSUE;

WAVELENGTH;

PHOTODYNAMIC THERAPY;

EID: 0141605842     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.474142     Document Type: Conference Paper

References (9)

1. T. J. Farrell and M. S. Patterson, "A diffusion theory model of spatially resolved, steady-state diffuse reflectance for the noninvasive determination of tissue optical properties in vivo," Medical Physics 19, 879-88 (1992).
2. E. L. Hull, M.G. Nichols, and T.H. Foster, "Quantitative broadband near-infrared spectroscopy of tissue-simulating phantoms containing erythrocytes," Physics in Medicine and Biology 43, 3381-404 (1998).
3. M. Solonenko, R. Cheung, T. M. Busch, et.al., "In vivo reflectance measurement of optical properties, blood oxygenation and motexafin lutetium uptake in canine large bowels, kidneys and prostates," Physics in Medicine and Biology 47, 857-73 (2002).
4. T. Ddurduran, R. Cchoe, J. P. Culver, L. Zubkov, M. J. Holboke, J. Giammarco, B. Chance, and A. G. Yodh, "Bulk optical properties of healthy female breast tissue," Physics in Medicine and biology 47, 2847-2861 (2002).
5. S. Prahl, Optical Properties spectra (webpate http://omic.ogi.edu/spectra/index.html) (2001).
6. B. C. Wilson, P. J. Muller, and J. C. Yanch, "Instrumentation and light dosimetry for intra-operative photodynamic therapy (PDT) of malignant brain tumours," Physics in Medicine and Biology 31, 125-133 (1986).
7. P. J. Muller and B. C. Wilson, "An update on the penetration depth of 630nm light in normal and malignant human-brain tissue in vivo," Physics in Medicine and Biology 31, 1295-1297 (1986).
8. L. K. Lee, C. Whitehurst, M. L. Pantelides, and J. V. Moore, "An interstitial light assembly for photodynamic therapy in prostatic carcinoma," BJU Int 84, 821-826 (1999).
9. A. Maier, D. Sullmann, U. Anegg, F. Tomaselli, P. Rehak, H. Hutten, H. Pinter, and F. M. Smolle-Juttner, "In vivo determination of tumor optical parameters in esophageal carcinoma," Lasers Surg Med 27, 350-357 (2000).