Sequential changes of connexin32 and connexin26 in ischemia-reperfusion of the liver in rats

Hepatology Research

Volumn 27, Issue 1, 2003, Pages 67-75

  Nakashima, Yuichi ^a,b   Kohno, Hitoshi ^a   EL Assal, Osama N ^a   Dhar, Dipok K ^a   Ono, Takashi ^a   Yamanoi, Akira ^a   Nagasue, Naofumi ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b Unnan Municipal General Hospital   (Japan)

Author keywords

Calcium; Connexin26; Connexin32; Ischemia reperfusion injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CALCIUM; CONNEXIN 26; CONNEXIN 32; LACTATE DEHYDROGENASE; LIVER ENZYME; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL COMMUNICATION; CONTROLLED STUDY; DOWN REGULATION; GAP JUNCTION; IMMUNOFLUORESCENCE TEST; LIVER ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0141605444     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1386-6346(03)00188-8     Document Type: Article

References (33)

1. Cheung JY, Bonventre JV, Malis CD, Leaf A. Calcium and ischemic injury. N Engl J Med 1986;314:1670-6.
2. McCord JM. Oxygen-derived free radicals in postischemic tissue injury. N Engl J Med 1985;312:159-63.
3. Marubayashi S, Dohi K, Ezaki H, Hayashi K, Kawasaki T. Preservation of ischemic rat liver mitochondrial functions and liver viability with CoQ10. Surgery 1982;91:631-7.
4. Hayashi T, Nagasue N, Kohno H, Chang YC, Nakamura T. Beneficial effect of cyclosporine pretreatment in canine liver ischemia. Transplantation 1991;52:116-21.
5. Clemens MG, McDonagh PF, Chaudry IH, Baue AE. Hepatic microcirculatory failure after ischemia and reperfusion: improvement with ATP-MgCl2 treatment. Am J Physiol 1985;248:H804-11.
6. Uchida M, Nagasue N, Ono T, Takemoto Y, Dhar DK, Nakamura T. Effects of verapamil in ischemia reperfusion injury of rats livers - different actions in different lengths of ischemia. Surg Res Comm 1994;16:119-29.
7. Spray DC, Bai S, Burk RD, Saez JC. Regulation and function of liver gap junctions and their genes. In: Boyer JL, Ockner RK, editors. Progress in Liver Diseases, vol. 12:. Philadelphia, PA: Saunders, 1994:1-18.
8. Nathanson MH, Rois-Velez L, Burgstahler AD, Mennone A. Communication via gap junctions modulates bile secretion in the isolated perfused rat liver. Gastroenterology 1999;116:1176-83.
9. Estivill X, Fortina P, Surrey S, et al. Connexin-26 mutations in sporadic and inherited sensorineural deafness. Lancet 1998;351:394-8.
10. Kumar NM, Gilula NB. Cloning and chatacterization of human and rat liver cDNA coding for a gap junction protein. J Cell Biol 1986;103:767-76.
11. Paul DL. Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol 1986;103:123-34.
12. Zhang J-T, Nicolson BJ. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol 1989;109:3391-401.
13. Neveu MJ, Hurry JR, Babcock KL, et al. Proliferation-associated differences in the spatial and temporal expression of gap juction genes in rat liver. Hepatology 1995;22:202-12.
14. Nicolson B, Dermietzel R, Teplow D, Traub O, Willecke K, Revel JP. Two homologous protein components of hepatic gap junctions. Nature 1987;392:732-4.
15. Gingalewski C, Wang K, Clemens MG, De Maio A. Posttranscriptional regulation of connexin 32 expression in liver during acute inflammation. J Cell Physiol 1996;166:461-7.
16. Krutovskikh VA, Oyamada M, Yamasaki H. Sequential changes of gap-junctional intercellular communications during multistage rat liver carcinogenesis: direct measurement of communication in vivo. Carcinogenesis 1991;12:1701-6.
17. Gingalewski C, De Maio A. Differential disease in connexin 32 expression in ischemic and nonischemic regions of rat liver during ischemia/reperfusion. J Cell Physiol 1997;171:20-7.
18. Schellens JPM, Blange T, Groot KD. Gap junction ultrastructure in rat liver parenchymal cells after in vivo ischemia. Virch Arch B 1987;53:347-52.
19. El-Mofty SK, Scrutton MC, Serroni A, Nicolini C, Farber JL. Early, reversible plasma membrane injury in galactosamine-induced liver cell death. Am J Pathol 1975;79:579-96.
20. Takeda A, Katoh M, Shimizu T, Kakeuchi N. Monoclonal antibodies recognizing different epitopes of the 27-kDa gap junction protein from rat liver. J Biochem 1988;104:901-7.
21. Watanabe T, Katsura Y, Yoshitake A. IPAP: image processor for analytical pathology. J Toxicol Pathol 1994;7:353-61.
22. Ito S, Tateno C, Tanaka M, Yoshitake A. Effects of fenvalerate and esfenvalerate on hepatic gap junctional intercellular communication in rats. Cell Biol Toxicol 1993;9:189-96.
23. El-Assal ON, Yamanoi A, Soda Y, et al. Clinical significance of microvessel density and vascular endothelial growth factor expression in hepatocellular carcinoma and surrounding liver: possible involvement of vascular endothelial growth factor in the angiogenesis of cirrhotic liver. Hepatology 1998;27:1554-62.
24. Saez JC, Connor JA, Spray DC, Bennet MVL. Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-triphosphate and calcium ions. Proc Natl Acad Sci USA 1989;86:2708-12.
25. 2+. Am J Physiol 1987;253:C607-12.
26. Lazrak A, Peracchia C. Gap junction gating sensitivity to physiological internal calcium regardless of pH in Novikoff hepatoma cells. Biophys J 1993;65:2002-12.
27. Jara PI, Boric MP, Saez JC. Leukocytes express connexin 43 after activation with lipopolysaccharide and appear to form gap junctions with endothelial cells after ischemia-reperfusion. Proc Natl Acad Sci USA 1995;18:7011-5.
28. Temme A, Ott T, Dombrowski F, Willecke K. The extent of synchronous initiation and termination of DNA synthesis in regenerating mouse liver is dependent on connexin32 expressing gap junctions. J Hepatol 2000;32:627-35.
29. Yamaguchi M, Kanayama Y. Enhanced expression of calcium-bindinding protein regucalcin mRNA in regenerating rat liver. J Cell Biochem 1995;57:185-90.
30. Ueda F, Ban K, Ishima T. Irsogladine activates gap-junctional inter-cellular communication through M1 muscarinic acetylcholine receptor. J Pharmacol Exp Ther 1995;274:815-9.
31. Nakashima Y, Kohno H, El-Assal ON, Dhar DK, Ueda F, Nagasue N. Irsogladine upregulates expressions of connexin32 and connexin26 in the rat liver. Hepatol Res 2000;18:29-42.
32. Mizoguchi Y, Kawada N, Ichikawa Y, Kobayashi K, Morisawa S. Effects of irsogladine maleate in an experimentally-induced acute hepatic failure model using mice. Gastroenterol Jpn 1991;26:177-81.
33. Iwata F, Joh T, Ueda F, Yokoyama Y, Itoh M. Role of gap junctions in inhibiting ischemia-reperfusion injury of rat gastric mucosa. Am J Physiol 1998;275:G883-8.