Preparation of enol ethers by carbonyl olefination utilizing an alkoxymethyl chloride-titanocene(II) system

Tetrahedron Letters

Volumn 44, Issue 43, 2003, Pages 7897-7900

  Takeda, Takeshi ^a   Shono, Tomohiro ^a   Ito, Kenji ^a   Sasaki, Hironori ^a   Tsubouchi, Akira ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Carbonyl compounds; Enol ethers; Olefination; Titanium and compounds

Indexed keywords

ALDEHYDE; ALKENE DERIVATIVE; CARBONYL DERIVATIVE; ESTER; ETHER DERIVATIVE; KETONE; LACTONE; METHYL GROUP; TITANIUM DERIVATIVE; TITANOCENE;

ARTICLE; CHEMICAL REACTION; OLEFINATION; SYNTHESIS;

EID: 0141596923     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.09.013     Document Type: Article

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15. 3 (6.0 mmol), and the mixture was stirred for 20 min. The mixture was warmed up to -10°C and a THF (1 mL) solution of 2a (119 mg, 0.50 mmol) was added over 10 min. After stirring for 3 h, the reaction was quenched by addition of 1 M NaOH. The usual work-up and purification gave 88 mg of 4i in 66% yield.
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