Synthesis of oligonucleotide-peptide PEG-conjugated: The EGG (oligonucleotide)-chicken (peptide) dilemma?

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1255-1257

  Bonora, Gian Maria ^a   Ballico, Maurizio ^a   Campaner, Pietro ^a   Drioli, Sara ^a   Adamo, Ilaria ^b  

^a UNIVERSITY OF TRIESTE   (Italy)

^b UNIV MONTPELLIER   (France)

Author keywords

Conjugate; Oligonucleotide; Peptide; Polyethylene glycol

Indexed keywords

CHIMERIC PROTEIN; MACROGOL; OLIGONUCLEOTIDE; PEPTIDE;

CONFERENCE PAPER; CONJUGATION; NUCLEIC ACID SYNTHESIS; REACTION ANALYSIS;

BASE SEQUENCE; INDICATORS AND REAGENTS; NUCLEIC ACID HYBRIDIZATION; PEPTIDE NUCLEIC ACIDS; POLYETHYLENE GLYCOLS;

GALLUS GALLUS;

EID: 0141596238     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022849     Document Type: Conference Paper

References (7)

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2. Greenwald, R.B. PEG drugs: an overview. Journal of Controlled Release 2001, 74, 159-171.
3. Bonora, G.M. Polyethylene glycol. A high-efficiency liquid phase (HELP) for the large-scale synthesis of the oligonucleotides. Applied Biochem. and Biotech. 1995, 54, 3-17.
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5. Drioli, S.; Adamo, I.; Ballico, M.; Morvan, F.; Bonora, G.M. Liquid-phase synthesis and characterization of a chimeric oligonucleotide-PEG-peptide. Eur. J. Org. Chem. 2002, 3473-3480.
6. Drioli, S.; Benedetti, F.; Bonora, G.M. Pure, homo-bifunctional poly(ethylene glycol) orthogonally protected: synthesis and characterisation. Reactive and Functional Polymer 2001, 48, 119-128.
7. Juby, C.D.; Richardson, C.D.; Brousseau, R. Facile preparation of 3′-oligonucleotide-peptide conjugates. Tetrahedron Lett. 1991, 32, 879-882.